fenfluramine has been researched along with Appetite Disorders in 27 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine." | 7.67 | Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988) |
| " Adverse events were usually moderate and transient, occurring at the beginning of treatment." | 6.68 | [A multicenter open study of dexfenfluramine in Italy. The efficacy and safety of using dexfenfluramine in treating patients with simple or complicated obesity. The DIMOS Group]. ( Enzi, G, 1997) |
| "22 severe binge eaters, 17 moderate binge eaters, and 16 non-binge eaters received phentermine resin 15mg/day and dl-fenfluramine 20mg three times daily over a 6 month period for weight loss." | 3.70 | Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters. ( Alger, SA; Cerulli, J; Fein, S; Howard, L; Malone, M, 1999) |
| "The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine." | 3.67 | Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988) |
| " Adverse events were usually moderate and transient, occurring at the beginning of treatment." | 2.68 | [A multicenter open study of dexfenfluramine in Italy. The efficacy and safety of using dexfenfluramine in treating patients with simple or complicated obesity. The DIMOS Group]. ( Enzi, G, 1997) |
| "Increased research focusing on the eating disorders has put the clinician on firmer ground when choosing appropriate psychopharmacologic treatments." | 2.37 | Pharmacologic treatment of eating disorders. ( Gwirtsman, H; Jimerson, DC; Kaye, W; Weintraub, M, 1984) |
| "Ten adult subjects were referred to our sleep disorders center complaining of difficulty in maintaining sleep due to frequent and recurrent awakenings to eat or drink." | 1.29 | Nocturnal eating syndrome in adults. ( Granella, F; Marchesi, C; Melli, I; Parrino, L; Spaggiari, MC; Terzano, MG, 1994) |
| "0 mg/kg) when given at high dosage (8, 16 mumol/kg s." | 1.29 | d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors. ( Curzon, G; Gibson, EL; Kennedy, AJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (70.37) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gwirtsman, H | 1 |
| Kaye, W | 1 |
| Weintraub, M | 1 |
| Jimerson, DC | 2 |
| Samanin, R | 3 |
| Caccia, S | 1 |
| Bendotti, C | 1 |
| Borsini, F | 1 |
| Borroni, E | 1 |
| Invernizzi, R | 1 |
| Pataccini, R | 1 |
| Mennini, T | 1 |
| Leshem, M | 1 |
| Oluyomi, AO | 1 |
| Gibson, EL | 2 |
| Barnfield, AM | 1 |
| Curzon, G | 2 |
| Spaggiari, MC | 1 |
| Granella, F | 1 |
| Parrino, L | 1 |
| Marchesi, C | 1 |
| Melli, I | 1 |
| Terzano, MG | 1 |
| Kennedy, AJ | 1 |
| Enzi, G | 1 |
| Alger, SA | 1 |
| Malone, M | 1 |
| Cerulli, J | 1 |
| Fein, S | 1 |
| Howard, L | 1 |
| Wurtman, J | 1 |
| Wurtman, R | 1 |
| Mark, S | 1 |
| Tsay, R | 1 |
| Gilbert, W | 1 |
| Growdon, J | 1 |
| Antelman, SM | 1 |
| Caggiula, AR | 1 |
| Black, CA | 1 |
| Edwards, DJ | 1 |
| Shoulson, I | 1 |
| Chase, TN | 1 |
| Finer, N | 1 |
| McBride, PA | 1 |
| Anderson, GM | 1 |
| Khait, VD | 1 |
| Sunday, SR | 1 |
| Halmi, KA | 1 |
| Lesem, MD | 1 |
| Hegg, AP | 1 |
| Brewerton, TD | 1 |
| Miranda, GF | 1 |
| Poggesi, E | 1 |
| Bianchetti, A | 1 |
| Unkovic, J | 1 |
| Garattini, S | 1 |
| Stallone, D | 1 |
| Nicolaïdis, S | 1 |
| Gibbs, J | 1 |
| Robinson, PH | 2 |
| McHugh, PR | 1 |
| Moran, TH | 1 |
| Stephenson, JD | 1 |
| Pope, HG | 1 |
| Hudson, JI | 1 |
| Wolgin, DL | 1 |
| Oslan, IA | 1 |
| Thompson, GB | 1 |
| Wurtman, JJ | 1 |
| Nathan, C | 1 |
| Rolland, Y | 1 |
| Majeed, NH | 1 |
| Lasoń, W | 1 |
| Przewłocka, B | 1 |
| Przewłocki, R | 1 |
| Rowland, NE | 1 |
| Carlton, J | 1 |
| Checkley, SA | 1 |
| Russell, GF | 1 |
| Fibiger, HC | 1 |
| Zis, AP | 1 |
| McGeer, EG | 1 |
| Opitz, K | 1 |
9 reviews available for fenfluramine and Appetite Disorders
| Article | Year |
|---|---|
Pharmacologic treatment of eating disorders.
Topics: Anorexia Nervosa; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Central | 1984 |
Serotoninergic system: therapeutic implications in obesity.
Topics: Appetite Depressants; Feeding and Eating Disorders; Female; Fenfluramine; Humans; Male; Obesity; Ser | 1992 |
Serotonin in human eating disorders.
Topics: Anorexia Nervosa; Bulimia; Feeding and Eating Disorders; Feeding Behavior; Fenfluramine; Humans; Ser | 1990 |
Serotonin and the pharmacology of eating disorders.
Topics: Animals; Appetite; Brain; Brain Chemistry; Eating; Feeding and Eating Disorders; Feeding Behavior; F | 1989 |
Gastric control of food intake.
Topics: Animals; Eating; Feeding and Eating Disorders; Fenfluramine; Gastric Emptying; Humans; Macaca mulatt | 1988 |
Antidepressant drug therapy for bulimia: current status.
Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method | 1986 |
Disorders of food intake. Excessive carbohydrate snack intake among a class of obese people.
Topics: Dietary Carbohydrates; Emotions; Feeding and Eating Disorders; Feeding Behavior; Fenfluramine; Human | 1987 |
Pharmacological treatments that affect CNS activity: serotonin.
Topics: Animals; Antidepressive Agents; Body Weight; Compulsive Behavior; Eating; Energy Intake; Feeding and | 1987 |
Neurobiology of an anorectic drug: fenfluramine.
Topics: Acute Disease; Adipose Tissue; Animals; Anorexia; Arousal; Avoidance Learning; Behavior Therapy; Bod | 1986 |
5 trials available for fenfluramine and Appetite Disorders
| Article | Year |
|---|---|
[A multicenter open study of dexfenfluramine in Italy. The efficacy and safety of using dexfenfluramine in treating patients with simple or complicated obesity. The DIMOS Group].
Topics: Adolescent; Adult; Aged; Analysis of Variance; Appetite Depressants; Diabetes Mellitus; Diabetes Mel | 1997 |
d-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects.
Topics: Adult; Appetite Depressants; Dietary Carbohydrates; Dietary Proteins; Eating; Energy Intake; Feeding | 1985 |
Fenfluramine in man: hypophagia associated with diminished serotonin turnover.
Topics: Adult; Appetite; Body Weight; Clinical Trials as Topic; Depression, Chemical; Dopamine; Feeding and | 1975 |
Antidepressant drug therapy for bulimia: current status.
Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method | 1986 |
Suppression of eating by fenfluramine in patients with bulimia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Depression, Chemical; Eating; Feeding and Eating Disorders; Fem | 1985 |
14 other studies available for fenfluramine and Appetite Disorders
| Article | Year |
|---|---|
Further studies on the mechanism of serotonin-dependent anorexia in rats.
Topics: Animals; Anorexia; Brain; Feeding and Eating Disorders; Feeding Behavior; Female; Fenfluramine; Huma | 1980 |
Morphine-induced anorexia in lateral hypothalamic rats.
Topics: Amphetamine; Animals; Anorexia; Dextroamphetamine; Feeding and Eating Disorders; Fenfluramine; Human | 1981 |
d-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release.
Topics: Animals; Eating; Feeding and Eating Disorders; Fenclonine; Fenfluramine; Hypothalamus; Male; Microdi | 1994 |
Nocturnal eating syndrome in adults.
Topics: Adult; Body Mass Index; Circadian Rhythm; Compulsive Behavior; Dose-Response Relationship, Drug; Dru | 1994 |
d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.
Topics: Animals; Drug Interactions; Feeding and Eating Disorders; Fenclonine; Fenfluramine; Male; Norfenflur | 1993 |
Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters.
Topics: Adult; Appetite Depressants; Depression; Eating; Feeding and Eating Disorders; Female; Fenfluramine; | 1999 |
Stress reverse the anorexia induced by amphetamine and methylphenidate but not fenfluramine.
Topics: Animals; Anorexia; Dextroamphetamine; Dose-Response Relationship, Drug; Feeding and Eating Disorders | 1978 |
Serotonergic responsivity in eating disorders.
Topics: Adolescent; Adult; Blood Platelets; Feeding and Eating Disorders; Female; Fenfluramine; Humans; Neur | 1991 |
Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine.
Topics: Animals; Appetite Depressants; Body Weight; Diet; Dogs; Eating; Feeding and Eating Disorders; Female | 1988 |
Cholecystokinin-induced anorexia depends on serotoninergic function.
Topics: Amidines; Animals; Anorexia; Cholecystokinin; Dose-Response Relationship, Drug; Eating; Feeding and | 1989 |
Effects of "anorexia" on appetitive and consummatory behavior.
Topics: Amphetamine; Animals; Anorexia; Appetite; Feeding and Eating Disorders; Feeding Behavior; Fenflurami | 1988 |
Involvement of endogenous opioid peptides in fenfluramine anorexia.
Topics: Animals; Anorexia; Body Weight; Duodenum; Endorphins; Feeding and Eating Disorders; Feeding Behavior | 1986 |
Feeding and drinking deficits after 6-hydroxydopamine administration in the rat: similarities to the lateral hypothalamic syndrome.
Topics: Amphetamine; Animals; Catecholamines; Corpus Striatum; Disease Models, Animal; Drinking Behavior; Fe | 1973 |
[Anorexigenic phenylalkylamines and serotonin metabolism].
Topics: 5-Hydroxytryptophan; Animals; Appetite Depressants; Chlorphentermine; Diarrhea; Eating; Feeding and | 1967 |