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fenfluramine and Appetite Disorders

fenfluramine has been researched along with Appetite Disorders in 27 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research Excerpts

ExcerptRelevanceReference
"The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine."7.67Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988)
" Adverse events were usually moderate and transient, occurring at the beginning of treatment."6.68[A multicenter open study of dexfenfluramine in Italy. The efficacy and safety of using dexfenfluramine in treating patients with simple or complicated obesity. The DIMOS Group]. ( Enzi, G, 1997)
"22 severe binge eaters, 17 moderate binge eaters, and 16 non-binge eaters received phentermine resin 15mg/day and dl-fenfluramine 20mg three times daily over a 6 month period for weight loss."3.70Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters. ( Alger, SA; Cerulli, J; Fein, S; Howard, L; Malone, M, 1999)
"The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine."3.67Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988)
" Adverse events were usually moderate and transient, occurring at the beginning of treatment."2.68[A multicenter open study of dexfenfluramine in Italy. The efficacy and safety of using dexfenfluramine in treating patients with simple or complicated obesity. The DIMOS Group]. ( Enzi, G, 1997)
"Increased research focusing on the eating disorders has put the clinician on firmer ground when choosing appropriate psychopharmacologic treatments."2.37Pharmacologic treatment of eating disorders. ( Gwirtsman, H; Jimerson, DC; Kaye, W; Weintraub, M, 1984)
"Ten adult subjects were referred to our sleep disorders center complaining of difficulty in maintaining sleep due to frequent and recurrent awakenings to eat or drink."1.29Nocturnal eating syndrome in adults. ( Granella, F; Marchesi, C; Melli, I; Parrino, L; Spaggiari, MC; Terzano, MG, 1994)
"0 mg/kg) when given at high dosage (8, 16 mumol/kg s."1.29d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors. ( Curzon, G; Gibson, EL; Kennedy, AJ, 1993)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199019 (70.37)18.7374
1990's8 (29.63)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gwirtsman, H1
Kaye, W1
Weintraub, M1
Jimerson, DC2
Samanin, R3
Caccia, S1
Bendotti, C1
Borsini, F1
Borroni, E1
Invernizzi, R1
Pataccini, R1
Mennini, T1
Leshem, M1
Oluyomi, AO1
Gibson, EL2
Barnfield, AM1
Curzon, G2
Spaggiari, MC1
Granella, F1
Parrino, L1
Marchesi, C1
Melli, I1
Terzano, MG1
Kennedy, AJ1
Enzi, G1
Alger, SA1
Malone, M1
Cerulli, J1
Fein, S1
Howard, L1
Wurtman, J1
Wurtman, R1
Mark, S1
Tsay, R1
Gilbert, W1
Growdon, J1
Antelman, SM1
Caggiula, AR1
Black, CA1
Edwards, DJ1
Shoulson, I1
Chase, TN1
Finer, N1
McBride, PA1
Anderson, GM1
Khait, VD1
Sunday, SR1
Halmi, KA1
Lesem, MD1
Hegg, AP1
Brewerton, TD1
Miranda, GF1
Poggesi, E1
Bianchetti, A1
Unkovic, J1
Garattini, S1
Stallone, D1
Nicolaïdis, S1
Gibbs, J1
Robinson, PH2
McHugh, PR1
Moran, TH1
Stephenson, JD1
Pope, HG1
Hudson, JI1
Wolgin, DL1
Oslan, IA1
Thompson, GB1
Wurtman, JJ1
Nathan, C1
Rolland, Y1
Majeed, NH1
Lasoń, W1
Przewłocka, B1
Przewłocki, R1
Rowland, NE1
Carlton, J1
Checkley, SA1
Russell, GF1
Fibiger, HC1
Zis, AP1
McGeer, EG1
Opitz, K1

Reviews

9 reviews available for fenfluramine and Appetite Disorders

ArticleYear
Pharmacologic treatment of eating disorders.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:4

    Topics: Anorexia Nervosa; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Central

1984
Serotoninergic system: therapeutic implications in obesity.
    Acta clinica Belgica. Supplementum, 1992, Volume: 14

    Topics: Appetite Depressants; Feeding and Eating Disorders; Female; Fenfluramine; Humans; Male; Obesity; Ser

1992
Serotonin in human eating disorders.
    Annals of the New York Academy of Sciences, 1990, Volume: 600

    Topics: Anorexia Nervosa; Bulimia; Feeding and Eating Disorders; Feeding Behavior; Fenfluramine; Humans; Ser

1990
Serotonin and the pharmacology of eating disorders.
    Annals of the New York Academy of Sciences, 1989, Volume: 575

    Topics: Animals; Appetite; Brain; Brain Chemistry; Eating; Feeding and Eating Disorders; Feeding Behavior; F

1989
Gastric control of food intake.
    Journal of psychosomatic research, 1988, Volume: 32, Issue:6

    Topics: Animals; Eating; Feeding and Eating Disorders; Fenfluramine; Gastric Emptying; Humans; Macaca mulatt

1988
Antidepressant drug therapy for bulimia: current status.
    The Journal of clinical psychiatry, 1986, Volume: 47, Issue:7

    Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method

1986
Disorders of food intake. Excessive carbohydrate snack intake among a class of obese people.
    Annals of the New York Academy of Sciences, 1987, Volume: 499

    Topics: Dietary Carbohydrates; Emotions; Feeding and Eating Disorders; Feeding Behavior; Fenfluramine; Human

1987
Pharmacological treatments that affect CNS activity: serotonin.
    Annals of the New York Academy of Sciences, 1987, Volume: 499

    Topics: Animals; Antidepressive Agents; Body Weight; Compulsive Behavior; Eating; Energy Intake; Feeding and

1987
Neurobiology of an anorectic drug: fenfluramine.
    Progress in neurobiology, 1986, Volume: 27, Issue:1

    Topics: Acute Disease; Adipose Tissue; Animals; Anorexia; Arousal; Avoidance Learning; Behavior Therapy; Bod

1986

Trials

5 trials available for fenfluramine and Appetite Disorders

ArticleYear
[A multicenter open study of dexfenfluramine in Italy. The efficacy and safety of using dexfenfluramine in treating patients with simple or complicated obesity. The DIMOS Group].
    Terapevticheskii arkhiv, 1997, Volume: 69, Issue:5

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Appetite Depressants; Diabetes Mellitus; Diabetes Mel

1997
d-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects.
    The International journal of eating disorders, 1985, Volume: 4, Issue:1

    Topics: Adult; Appetite Depressants; Dietary Carbohydrates; Dietary Proteins; Eating; Energy Intake; Feeding

1985
Fenfluramine in man: hypophagia associated with diminished serotonin turnover.
    Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:5

    Topics: Adult; Appetite; Body Weight; Clinical Trials as Topic; Depression, Chemical; Dopamine; Feeding and

1975
Antidepressant drug therapy for bulimia: current status.
    The Journal of clinical psychiatry, 1986, Volume: 47, Issue:7

    Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method

1986
Suppression of eating by fenfluramine in patients with bulimia nervosa.
    The British journal of psychiatry : the journal of mental science, 1985, Volume: 146

    Topics: Adolescent; Adult; Anorexia Nervosa; Depression, Chemical; Eating; Feeding and Eating Disorders; Fem

1985

Other Studies

14 other studies available for fenfluramine and Appetite Disorders

ArticleYear
Further studies on the mechanism of serotonin-dependent anorexia in rats.
    Psychopharmacology, 1980, Volume: 68, Issue:1

    Topics: Animals; Anorexia; Brain; Feeding and Eating Disorders; Feeding Behavior; Female; Fenfluramine; Huma

1980
Morphine-induced anorexia in lateral hypothalamic rats.
    Psychopharmacology, 1981, Volume: 75, Issue:1

    Topics: Amphetamine; Animals; Anorexia; Dextroamphetamine; Feeding and Eating Disorders; Fenfluramine; Human

1981
d-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release.
    European journal of pharmacology, 1994, Oct-13, Volume: 264, Issue:1

    Topics: Animals; Eating; Feeding and Eating Disorders; Fenclonine; Fenfluramine; Hypothalamus; Male; Microdi

1994
Nocturnal eating syndrome in adults.
    Sleep, 1994, Volume: 17, Issue:4

    Topics: Adult; Body Mass Index; Circadian Rhythm; Compulsive Behavior; Dose-Response Relationship, Drug; Dru

1994
d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.
    European journal of pharmacology, 1993, Sep-21, Volume: 242, Issue:1

    Topics: Animals; Drug Interactions; Feeding and Eating Disorders; Fenclonine; Fenfluramine; Male; Norfenflur

1993
Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters.
    Obesity research, 1999, Volume: 7, Issue:5

    Topics: Adult; Appetite Depressants; Depression; Eating; Feeding and Eating Disorders; Female; Fenfluramine;

1999
Stress reverse the anorexia induced by amphetamine and methylphenidate but not fenfluramine.
    Brain research, 1978, Mar-31, Volume: 143, Issue:3

    Topics: Animals; Anorexia; Dextroamphetamine; Dose-Response Relationship, Drug; Feeding and Eating Disorders

1978
Serotonergic responsivity in eating disorders.
    Psychopharmacology bulletin, 1991, Volume: 27, Issue:3

    Topics: Adolescent; Adult; Blood Platelets; Feeding and Eating Disorders; Female; Fenfluramine; Humans; Neur

1991
Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine.
    European journal of pharmacology, 1988, May-20, Volume: 150, Issue:1-2

    Topics: Animals; Appetite Depressants; Body Weight; Diet; Dogs; Eating; Feeding and Eating Disorders; Female

1988
Cholecystokinin-induced anorexia depends on serotoninergic function.
    The American journal of physiology, 1989, Volume: 256, Issue:5 Pt 2

    Topics: Amidines; Animals; Anorexia; Cholecystokinin; Dose-Response Relationship, Drug; Eating; Feeding and

1989
Effects of "anorexia" on appetitive and consummatory behavior.
    Behavioral neuroscience, 1988, Volume: 102, Issue:2

    Topics: Amphetamine; Animals; Anorexia; Appetite; Feeding and Eating Disorders; Feeding Behavior; Fenflurami

1988
Involvement of endogenous opioid peptides in fenfluramine anorexia.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:5

    Topics: Animals; Anorexia; Body Weight; Duodenum; Endorphins; Feeding and Eating Disorders; Feeding Behavior

1986
Feeding and drinking deficits after 6-hydroxydopamine administration in the rat: similarities to the lateral hypothalamic syndrome.
    Brain research, 1973, May-30, Volume: 55, Issue:1

    Topics: Amphetamine; Animals; Catecholamines; Corpus Striatum; Disease Models, Animal; Drinking Behavior; Fe

1973
[Anorexigenic phenylalkylamines and serotonin metabolism].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1967, Volume: 259, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Appetite Depressants; Chlorphentermine; Diarrhea; Eating; Feeding and

1967