Page last updated: 2024-10-26

fenfluramine and Apnea

fenfluramine has been researched along with Apnea in 2 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Apnea: A transient absence of spontaneous respiration.

Research Excerpts

ExcerptRelevanceReference
" The absence seizures were suppressed by treatment with valproate sodium, which had no effect on the self-induced apneas."3.67Syncopal attacks compulsively self-induced by Valsalva's maneuver associated with typical absence seizures. A case report. ( Aicardi, J; Gastaut, H; Misès, J, 1988)
" Polygraphic recording showed two types of syncope, one induced by prolonged apnea and the other by a prolonged Valsalva maneuver."3.67Compulsive respiratory stereotypies in children with autistic features: polygraphic recording and treatment with fenfluramine. ( Gastaut, H; Rufo, M; Zifkin, B, 1987)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aicardi, J1
Gastaut, H2
Misès, J1
Zifkin, B1
Rufo, M1

Other Studies

2 other studies available for fenfluramine and Apnea

ArticleYear
Syncopal attacks compulsively self-induced by Valsalva's maneuver associated with typical absence seizures. A case report.
    Archives of neurology, 1988, Volume: 45, Issue:8

    Topics: Apnea; Child; Child Behavior; Compulsive Behavior; Electroencephalography; Epilepsy, Absence; Female

1988
Compulsive respiratory stereotypies in children with autistic features: polygraphic recording and treatment with fenfluramine.
    Journal of autism and developmental disorders, 1987, Volume: 17, Issue:3

    Topics: Apnea; Autistic Disorder; Child; Child, Preschool; Compulsive Behavior; Electrocardiography; Electro

1987