Page last updated: 2024-10-27

fenfluramine and Aortic Valve Prolapse

fenfluramine has been researched along with Aortic Valve Prolapse in 1 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Aortic Valve Prolapse: The downward displacement of the cuspal or pointed end of the trileaflet AORTIC VALVE causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to aortic regurgitation.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ennezat, PV1
Bruneval, P1
Maréchaux, S1
Bellemin, JP1
Senellart, F1
Arnaud-Crozat, E1
Ramadan, R1
Obadia, JF1
Touati, G1
Fleury, JP1
Tribouilloy, C1

Other Studies

1 other study available for fenfluramine and Aortic Valve Prolapse

ArticleYear
Operative finding of aortic cusp prolapse in benfluorex-induced aortic regurgitation.
    International journal of cardiology, 2015, Volume: 186

    Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Aortic Valve Prolapse; Appetite Depressants;

2015