fenfluramine has been researched along with Aortic Valve Insufficiency in 42 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Aortic Valve Insufficiency: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benfluorex was withdrawn from European markets in June 2010 after reports of an association with heart valve lesions." | 5.38 | Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study. ( Arnalsteen, E; Boulanger, J; Donal, E; Ederhy, S; Ennezat, PV; Garban, T; Jeu, A; Jobic, Y; Maréchaux, S; Réant, P; Rusinaru, D; Tribouilloy, C, 2012) |
| "Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2." | 5.36 | Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010) |
| "Nineteen participants, all of whom had hypertension, were being treated with fenfluramine or dexfenfluramine (5 on these agents alone, 14 also with phentermine)." | 3.71 | Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study. ( Arnett, DK; Bella, JN; de Simone, G; Devereux, RB; Hopkins, PN; Kitzman, DW; Liu, JE; Morgan, D; Oberman, A; Palmieri, V; Roman, MJ, 2002) |
| "Serotoninergic appetite-suppressant drugs, fenfluramine and dexfenfluramine, were withdrawn from the market in September 1997 on account of two major cardiopulmonary complications: primary pulmonary hypertension and valvular regurgitation." | 3.70 | [Appetite suppressants and heart valve disorders]. ( Adams, C; Cohen, A, 1999) |
| "To evaluate cardiovascular status and the prevalence of valvular abnormalities, as assessed by clinical cardiovascular parameters and echocardiography, in patients treated for obesity with dexfenfluramine or phentermine/fenfluramine." | 3.70 | Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine. ( Constantine, G; Davis, KD; Gardin, JM; Leung, C; Reid, CL; Schumacher, D, 2000) |
| "Aortic regurgitation was detected in 18 subjects, mitral regurgitation in 3 subjects, and both aortic and mitral regurgitation in 1 subject; no one had severe regurgitation." | 2.70 | Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs. ( Blackburn, GL; Burger, AJ; Charlamb, MJ; Notarianni, M; Sherman, HB; Singh, S, 2001) |
| "These analyses showed that aortic regurgitation of mild or greater severity occurred in 5." | 2.69 | An assessment of heart-valve abnormalities in obese patients taking dexfenfluramine, sustained-release dexfenfluramine, or placebo. Sustained-Release Dexfenfluramine Study Group. ( Gottdiener, JS; Gwynne, JT; Tighe, JF; Weissman, NJ, 1998) |
| "Benfluorex was withdrawn from European markets in June 2010 after reports of an association with heart valve lesions." | 1.38 | Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study. ( Arnalsteen, E; Boulanger, J; Donal, E; Ederhy, S; Ennezat, PV; Garban, T; Jeu, A; Jobic, Y; Maréchaux, S; Réant, P; Rusinaru, D; Tribouilloy, C, 2012) |
| "Adjusted RR for mitral insufficiency and aortic insufficiency admissions were 2." | 1.36 | Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus. ( Allemand, H; Fagot, JP; Montastruc, JL; Neumann, A; Païta, M; Ricordeau, P; Simon, D; Tuppin, P; Weill, A, 2010) |
| " The dose-response relationship between the cumulative dose of drugs and the presence of aortic regurgitation was significant for fenfluramine only (chi-square=5." | 1.32 | High prevalence of fenfluramine-related aortic regurgitation in women with end-stage renal disease secondary to Chinese herb nephropathy. ( Muniz Martinez, MC; Nortier, J; Plein, D; Unger, P; Vandenbossche, JL; Vanherweghem, JL; Vereerstraeten, P, 2003) |
| "Mild or greater aortic regurgitation was present in 8." | 1.31 | Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities. ( Constantine, GD; Davis, KD; Jollis, JG; Kisslo, J; Landolfo, CK; Ryan, T, 2000) |
| "The most common finding was mild aortic regurgitation." | 1.31 | Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience. ( Connolly, HM; Grogan, M; Miller, FA; Teramae, CY, 2000) |
| "There were six cases of aortic regurgitation, two cases of mitral regurgitation, and three cases of combined aortic and mitral regurgitation." | 1.30 | A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation. ( Derby, LE; Jick, H; Jick, SS; Meier, CR; Vasilakis, C; Weinrauch, LA, 1998) |
| " The Ministry of Health has recently alerted practitioners to the possible risk of heart valve damage following the long-term use of weight-loss drugs fenfluramine (Ponderax) and dexfenfluramine (Adifax)." | 1.30 | Prevention of infective endocarditis associated with dental treatment and other medical interventions. National Heart Foundation. ( Ellis-Pegler, RB; Hay, KD; Lang, SD; Neutze, JM; Swinburn, BA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (33.33) | 18.2507 |
| 2000's | 16 (38.10) | 29.6817 |
| 2010's | 12 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trinh, NTH | 1 |
| Solé, E | 1 |
| Benkebil, M | 1 |
| Nicot, P | 1 |
| Frachon, I | 2 |
| Hill, C | 1 |
| Tribouilloy, C | 6 |
| Maréchaux, S | 4 |
| Jobic, Y | 5 |
| Jeu, A | 3 |
| Ederhy, S | 2 |
| Donal, E | 2 |
| Réant, P | 2 |
| Arnalsteen, E | 2 |
| Boulanger, J | 2 |
| Garban, T | 2 |
| Ennezat, PV | 4 |
| Andréjak, M | 3 |
| Rusinaru, D | 4 |
| Borer, JS | 1 |
| Plurien, F | 1 |
| Bruneval, P | 3 |
| Iung, B | 1 |
| Bellemin, JP | 1 |
| Senellart, F | 1 |
| Arnaud-Crozat, E | 1 |
| Ramadan, R | 1 |
| Obadia, JF | 1 |
| Touati, G | 1 |
| Fleury, JP | 1 |
| Weill, A | 1 |
| Païta, M | 1 |
| Tuppin, P | 1 |
| Fagot, JP | 1 |
| Neumann, A | 1 |
| Simon, D | 1 |
| Ricordeau, P | 1 |
| Montastruc, JL | 1 |
| Allemand, H | 1 |
| Etienne, Y | 1 |
| Sachdev, M | 1 |
| Miller, WC | 1 |
| Ryan, T | 3 |
| Jollis, JG | 4 |
| Unger, P | 1 |
| Nortier, J | 1 |
| Muniz Martinez, MC | 1 |
| Plein, D | 1 |
| Vandenbossche, JL | 1 |
| Vereerstraeten, P | 1 |
| Vanherweghem, JL | 1 |
| Hopkins, PN | 2 |
| Polukoff, GI | 1 |
| Connolly, HM | 2 |
| Crary, JL | 2 |
| McGoon, MD | 1 |
| Hensrud, DD | 1 |
| Edwards, BS | 1 |
| Edwards, WD | 1 |
| Schaff, HV | 1 |
| Rasmussen, S | 1 |
| Corya, BC | 1 |
| Glassman, RD | 1 |
| Khan, MA | 1 |
| Herzog, CA | 1 |
| St Peter, JV | 1 |
| Hartley, GG | 1 |
| Madlon-Kay, R | 1 |
| Dick, CD | 1 |
| Asinger, RW | 1 |
| Vessey, JT | 1 |
| Jick, H | 1 |
| Vasilakis, C | 1 |
| Weinrauch, LA | 1 |
| Meier, CR | 1 |
| Jick, SS | 1 |
| Derby, LE | 1 |
| Weissman, NJ | 1 |
| Tighe, JF | 1 |
| Gottdiener, JS | 1 |
| Gwynne, JT | 1 |
| Van Ypersele de Strihou, C | 1 |
| Ono, T | 1 |
| Eri, M | 1 |
| Honda, G | 1 |
| Kuwahara, T | 1 |
| Jensen, K | 1 |
| Godeau, P | 1 |
| Cherin, P | 1 |
| Tellier, P | 1 |
| Ryan, DH | 1 |
| Bray, GA | 1 |
| Helmcke, F | 1 |
| Sander, G | 1 |
| Volaufova, J | 1 |
| Greenway, F | 1 |
| Subramaniam, P | 1 |
| Glancy, DL | 1 |
| Pi-Sunyer, FX | 1 |
| Adams, C | 1 |
| Cohen, A | 1 |
| Ellis-Pegler, RB | 1 |
| Hay, KD | 1 |
| Lang, SD | 1 |
| Neutze, JM | 1 |
| Swinburn, BA | 1 |
| Kancherla, MK | 1 |
| Salti, HI | 1 |
| Mulderink, TA | 1 |
| Parker, M | 1 |
| Bonow, RO | 1 |
| Mehlman, DJ | 1 |
| Gardin, JM | 1 |
| Schumacher, D | 1 |
| Constantine, G | 1 |
| Davis, KD | 2 |
| Leung, C | 1 |
| Reid, CL | 1 |
| Landolfo, CK | 1 |
| Kisslo, J | 1 |
| Constantine, GD | 1 |
| Teramae, CY | 1 |
| Grogan, M | 1 |
| Miller, FA | 1 |
| Lepor, NE | 1 |
| Gross, SB | 1 |
| Daley, WL | 1 |
| Samuels, BA | 1 |
| Rizzo, MJ | 1 |
| Luko, SP | 1 |
| Hickey, A | 1 |
| Buchbinder, NA | 1 |
| Naqvi, TZ | 1 |
| Moyé, LA | 1 |
| Annegers, AF | 1 |
| Melero Tejedor, JM | 1 |
| Rodríguez Bailón, I | 1 |
| Such Martínez, M | 1 |
| Porras Martín, C | 1 |
| Olalla Mercadé, E | 1 |
| Espinosa Caliani, JS | 1 |
| St John Sutton, M | 1 |
| Mast, ST | 2 |
| Anstrom, KJ | 2 |
| Gersing, KR | 1 |
| Krishnan, KR | 1 |
| Califf, RM | 1 |
| Burger, AJ | 1 |
| Charlamb, MJ | 1 |
| Singh, S | 1 |
| Notarianni, M | 1 |
| Blackburn, GL | 1 |
| Sherman, HB | 1 |
| Volmar, KE | 1 |
| Hutchins, GM | 1 |
| Dahl, CF | 1 |
| Allen, MR | 1 |
| Palmieri, V | 1 |
| Arnett, DK | 1 |
| Roman, MJ | 1 |
| Liu, JE | 1 |
| Bella, JN | 1 |
| Oberman, A | 1 |
| Kitzman, DW | 1 |
| Morgan, D | 1 |
| de Simone, G | 1 |
| Devereux, RB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Sulphate-bicarbonate-calcium Water Consumption on the Body Weight and Gut Microbiota Composition in Overweight and Obese Patients Under Low-calorie Diet[NCT02154230] | 0 participants (Actual) | Interventional | 2013-11-30 | Withdrawn (stopped due to failure to enroll) | |||
| [NCT00005267] | 3,604 participants (Actual) | Observational | 1995-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fenfluramine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
[About the settlement of litigations concerning the harm caused by benfluorex (Mediator®)].
Topics: Aortic Valve Insufficiency; Appetite Depressants; Causality; Compensation and Redress; Cross-Section | 2013 |
[Benfluorex and valvular heart disease].
Topics: Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Cross-Sectional Studies; Echocardi | 2011 |
Effect of fenfluramine-derivative diet pills on cardiac valves: a meta-analysis of observational studies.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Fenfluramine; Heart Valve Disease | 2002 |
Risk of valvular heart disease associated with use of fenfluramine.
Topics: Aortic Valve Insufficiency; Bias; Case-Control Studies; Dexfenfluramine; Fenfluramine; Humans; Incid | 2003 |
3 trials available for fenfluramine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
An assessment of heart-valve abnormalities in obese patients taking dexfenfluramine, sustained-release dexfenfluramine, or placebo. Sustained-Release Dexfenfluramine Study Group.
Topics: Adult; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Blood Pressure; Delayed-Actio | 1998 |
Echocardiographic prevalence of mitral and/or aortic regurgitation in patients exposed to either fenfluramine-phentermine combination or to dexfenfluramine.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; De | 1999 |
Low risk of significant echocardiographic valvulopathy in patients treated with anorectic drugs.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Boston; Drug Therapy, Combination; Female; Fenflur | 2001 |
35 other studies available for fenfluramine and Aortic Valve Insufficiency
| Article | Year |
|---|---|
Benefits of combining change-point analysis with disproportionality analysis in pharmacovigilance signal detection.
Topics: Adverse Drug Reaction Reporting Systems; Aortic Valve Insufficiency; Appetite Depressants; Data Inte | 2019 |
Frequency of drug-induced valvular heart disease in patients previously exposd to benfluorex: a multicentre prospective study.
Topics: Analysis of Variance; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Diabet | 2013 |
Drug-induced valve disease and considerations of benefit versus risk.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Humans; Hypolipidemic Agents | 2013 |
Calcifications in benfluorex-induced valve heart disease: a misknown association.
Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Calcinosis; Fenfluramine; Heart Valve Diseas | 2015 |
Operative finding of aortic cusp prolapse in benfluorex-induced aortic regurgitation.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Aortic Valve Prolapse; Appetite Depressants; | 2015 |
Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus.
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Databases, Factual; D | 2010 |
How can benfluorex-related heart valve disease be identified by echocardiography?
Topics: Aortic Valve Insufficiency; Appetite Depressants; Echocardiography, Doppler, Color; Female; Fenflura | 2011 |
[Letter on the article: "benfluorex and valvular heart disease"].
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Humans; Male; Mitral Valve I | 2012 |
Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus: a multicenter study.
Topics: Aged; Aortic Valve Insufficiency; Appetite Depressants; Diabetes Mellitus; Echocardiography; Europe; | 2012 |
Benfluorex: lesions on a bioprosthetic heart valve too.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Bioprosthesis; Device Removal; Drug Adminis | 2012 |
High prevalence of fenfluramine-related aortic regurgitation in women with end-stage renal disease secondary to Chinese herb nephropathy.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Dose-Response Relationship, | 2003 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Drug Combinations; Female; Fenfluramine; He | 1997 |
Valvular heart disease associated with fenfluramine-phentermine.
Topics: Aortic Valve Insufficiency; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramin | 1997 |
The prevalence of cardiac valvular insufficiency assessed by transthoracic echocardiography in obese patients treated with appetite-suppressant drugs.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Cross-Sectional Studi | 1998 |
A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation.
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Drug Combinatio | 1998 |
Valvular heart disease and Chinese-herb nephropathy.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Drug Therapy, Combination; Drugs, Chinese Herbal; | 1998 |
Valvular heart disease and Chinese-herb nephropathy.
Topics: Aortic Valve Insufficiency; Drug Therapy, Combination; Drugs, Chinese Herbal; Fenfluramine; Humans; | 1998 |
[Recall of slimming agents fenfluramine and dexfenfluramine--for what reason?].
Topics: Aortic Valve Insufficiency; Appetite Depressants; Denmark; Drug and Narcotic Control; Fenfluramine; | 1998 |
[Pulmonary hypertension and heart valve diseases induced by fenfluramine? Hypothesis or certitude? Myth or reality?].
Topics: Animals; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine; He | 1998 |
Serial echocardiographic and clinical evaluation of valvular regurgitation before, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Counseling; Dexfenfluramine; Drug | 1999 |
Heart valve lesions in patients treated with appetite suppressants.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Echocardiography; Female; Fenflur | 1999 |
[Appetite suppressants and heart valve disorders].
Topics: Adult; Aged; Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Female; Fenfluramine | 1999 |
Prevention of infective endocarditis associated with dental treatment and other medical interventions. National Heart Foundation.
Topics: Adult; Anti-Obesity Agents; Antibiotic Prophylaxis; Aortic Valve Insufficiency; Cefuroxime; Cephalos | 1999 |
Valvular abnormalities and cardiovascular status following exposure to dexfenfluramine or phentermine/fenfluramine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Body Mass Index; Dexfenfluramine; Echocardiography | 2000 |
Fenfluramine and phentermine and cardiovascular findings: effect of treatment duration on prevalence of valve abnormalities.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Case-Control Studies; Drug Combinations; Female; F | 2000 |
Diet drug-related cardiac valve disease: the Mayo Clinic echocardiographic laboratory experience.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Diseases; Humans | 2000 |
Dose and duration of fenfluramine-phentermine therapy impacts the risk of significant valvular heart disease.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Blood Flow Velocity; Dose-Response Relationship, D | 2000 |
Underestimation of the valvulopathy effect of fenfluramine.
Topics: Adult; Aged; Aged, 80 and over; Aortic Valve Insufficiency; Echocardiography; Female; Fenfluramine; | 2000 |
[Valvular regurgitation caused by anorectic agents].
Topics: Aortic Valve Insufficiency; Appetite Depressants; Female; Fenfluramine; Heart Valve Prosthesis Impla | 2000 |
Silver lining to the cloud over anorexogen-related cardiac valvulopathy?
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Fenfluramine; Humans; Mitral | 2001 |
The progression of fenfluramine-associated valvular heart disease assessed by echocardiography.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Dexfenfluramine; Disease Pr | 2001 |
Association between selective serotonin-reuptake inhibitor therapy and heart valve regurgitation.
Topics: Aortic Valve Insufficiency; Cohort Studies; Echocardiography; Female; Fenfluramine; Humans; Male; Mi | 2001 |
Aortic and mitral fenfluramine-phentermine valvulopathy in 64 patients treated with anorectic agents.
Topics: Adult; Aged; Aortic Valve; Aortic Valve Insufficiency; Appetite Depressants; Drug Therapy, Combinati | 2001 |
Regression and progression of valvulopathy associated with fenfluramine and phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Drug Therapy, Combination; Ec | 2002 |
Appetite suppressants and valvular heart disease in a population-based sample: the HyperGEN study.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Dexfenfluramine; Drug Combinations; Female; Fenflu | 2002 |