fenfluramine has been researched along with Anxiety Neuroses in 13 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine, and indirect serotonergic agonist, was administered to nine women with panic disorder, nine women with major depressive disorder, and nine women controls." | 5.06 | Fenfluramine provocation of anxiety in patients with panic disorder. ( Marshall, LE; Targum, SD, 1989) |
| "The present study assessed the relation of cortisol response to anxiogenic reactivity during intravenous lactate infusion and oral fenfluramine in 12 panic disorder (PD) patients who responded positively to both challenges and in eight non-reactive control subjects." | 3.68 | Cortisol response during different anxiogenic challenges in panic disorder patients. ( Targum, SD, 1992) |
| "Anxiogenic challenge studies (intravenous lactate infusion and oral fenfluramine challenge) were conducted in 17 patients with panic disorder (PD), 12 patients with major depressive disorder and a history of panic attacks (MDD-PD), 27 patients with major depression and no history of panic (MDD), and 12 normal controls." | 3.68 | Differential responses to anxiogenic challenge studies in patients with major depressive disorder and panic disorder. ( Targum, SD, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garcia de Miguel, B | 1 |
| Nutt, DJ | 1 |
| Hood, SD | 1 |
| Davies, SJ | 1 |
| Sánchez, C | 1 |
| Abel, KM | 1 |
| O'Keane, V | 1 |
| Murray, RM | 1 |
| Ramasubbu, R | 1 |
| Andrews, TM | 1 |
| Anderson, IM | 1 |
| Targum, SD | 5 |
| Kahn, RS | 1 |
| van Praag, HM | 1 |
| Hollander, E | 1 |
| Liebowitz, MR | 1 |
| DeCaria, C | 1 |
| Klein, DF | 1 |
| Marshall, LE | 1 |
| Gaind, R | 1 |
1 review available for fenfluramine and Anxiety Neuroses
| Article | Year |
|---|---|
Elucidation of neurobiology of anxiety disorders in children through pharmacological challenge tests and cortisol measurements: a systematic review.
Topics: Anxiety Disorders; Brain; Carbon Dioxide; Child; Clonidine; Fenfluramine; Human Growth Hormone; Huma | 2012 |
3 trials available for fenfluramine and Anxiety Neuroses
| Article | Year |
|---|---|
Information processing in anxiety: a pilot study of the effect of manipulating 5-HT function.
Topics: Adult; Anxiety Disorders; Arousal; Attention; Cross-Over Studies; Double-Blind Method; Female; Fenfl | 1998 |
Fenfluramine provocation of anxiety in patients with panic disorder.
Topics: Adult; Anxiety Disorders; Arousal; Clinical Trials as Topic; Depressive Disorder; Fear; Female; Fenf | 1989 |
Fenfluramine (Ponderax) in the treatment of obese psychiatric out-patients.
Topics: Anxiety Disorders; Appetite Depressants; Body Weight; Clinical Trials as Topic; Depression; Diarrhea | 1969 |
9 other studies available for fenfluramine and Anxiety Neuroses
| Article | Year |
|---|---|
Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white text box.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; A | 1995 |
Enhancement of the prolactin response to d-fenfluramine in drug-naive schizophrenic patients.
Topics: Adult; Anxiety Disorders; Brain; Depressive Disorder; Female; Fenfluramine; Guilt; Humans; Hydrocort | 1996 |
Increased prolactin responses to d-fenfluramine in obsessive-compulsive disorder.
Topics: Anxiety Disorders; Fenfluramine; Humans; Obsessive-Compulsive Disorder; Prolactin; Serotonin Agents | 1998 |
Cortisol response during different anxiogenic challenges in panic disorder patients.
Topics: Administration, Oral; Adult; Anxiety Disorders; Arousal; Female; Fenfluramine; Humans; Hydrocortison | 1992 |
Panic attack frequency and vulnerability to anxiogenic challenge studies.
Topics: Administration, Oral; Adolescent; Adult; Anxiety Disorders; Arousal; Female; Fenfluramine; Humans; I | 1991 |
Panic disorder: a presynaptic serotonin defect?
Topics: Anxiety Disorders; Brain; Fear; Fenfluramine; Humans; Panic; Receptors, Serotonin; Serotonin; Synaps | 1990 |
Mechanisms of anxiogenic vulnerability in panic disorder.
Topics: Anxiety Disorders; Arousal; Depressive Disorder; Fear; Fenfluramine; Humans; Hydrocortisone; Panic; | 1990 |
Fenfluramine, cortisol, and anxiety.
Topics: Anxiety Disorders; Fear; Fenfluramine; Humans; Hydrocortisone; Lactates; Lactic Acid; Panic; Prolact | 1990 |
Differential responses to anxiogenic challenge studies in patients with major depressive disorder and panic disorder.
Topics: Administration, Oral; Adult; Anxiety Disorders; Arousal; Depressive Disorder; Diagnosis, Differentia | 1990 |