fenfluramine has been researched along with Antisocial Behavior in 8 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Antisocial Behavior: Behavior that sharply deviates from social norms and violates rights of others
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alcohol dependence has been associated with long-lasting alterations in limbic-hypothalamic-pituitary-adrenal (LHPA) axis and serotonin (5-hydroxytryptamine [5-HT]) function." | 2.70 | Stress hormone dysregulation at rest and after serotonergic stimulation among alcohol-dependent men with extended abstinence and controls. ( Anthenelli, RM; Geracioti, TD; Hauger, R; Maxwell, RA, 2001) |
| "Twelve heroin-dependent subjects with antisocial personality disorder (ASPD) (group A), 18 heroin-dependent subjects without other Axis I and II pathologies (group B) were included among abstinent substance abusers." | 1.32 | Neuroendocrine correlates of antisocial personality disorder in abstinent heroin-dependent subjects. ( Brambilla, F; Bussandri, M; Caccavari, R; Delsignore, R; Gerra, G; Moi, G; Zaimovic, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ivanov, I | 1 |
| Flory, J | 1 |
| Newcorn, JH | 3 |
| Halperin, JM | 3 |
| Gerra, G | 3 |
| Zaimovic, A | 3 |
| Moi, G | 1 |
| Bussandri, M | 1 |
| Delsignore, R | 3 |
| Caccavari, R | 3 |
| Brambilla, F | 3 |
| Marks, DJ | 1 |
| Miller, SR | 1 |
| Schulz, KP | 1 |
| Flory, JD | 1 |
| Miller, C | 1 |
| Harty, S | 1 |
| Fertonani, G | 1 |
| Tagliavini, P | 1 |
| Maestri, D | 2 |
| Avanzini, P | 1 |
| Palladino, M | 1 |
| Chittolini, B | 1 |
| Giucastro, G | 1 |
| Monica, C | 1 |
| Fertonani-Affini, G | 1 |
| Anthenelli, RM | 1 |
| Maxwell, RA | 1 |
| Geracioti, TD | 1 |
| Hauger, R | 1 |
| O'Keane, V | 1 |
| Moloney, E | 1 |
| O'Neill, H | 1 |
| O'Connor, A | 1 |
| Smith, C | 1 |
| Dinan, TG | 1 |
1 trial available for fenfluramine and Antisocial Behavior
| Article | Year |
|---|---|
Stress hormone dysregulation at rest and after serotonergic stimulation among alcohol-dependent men with extended abstinence and controls.
Topics: Adrenocorticotropic Hormone; Adult; Alcoholism; Analysis of Variance; Antisocial Personality Disorde | 2001 |
7 other studies available for fenfluramine and Antisocial Behavior
| Article | Year |
|---|---|
Childhood serotonergic function and early adult outcomes in youth with ADHD: A 15-year follow-up study.
Topics: Adult; Antisocial Personality Disorder; Attention Deficit Disorder with Hyperactivity; Female; Fenfl | 2018 |
Neuroendocrine correlates of antisocial personality disorder in abstinent heroin-dependent subjects.
Topics: Adrenergic alpha-Agonists; Adult; Antisocial Personality Disorder; Brain; Bromocriptine; Case-Contro | 2003 |
The interaction of psychosocial adversity and biological risk in childhood aggression.
Topics: Aggression; Antisocial Personality Disorder; Attention Deficit and Disruptive Behavior Disorders; Ch | 2007 |
Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder.
Topics: Adolescent; Adult; Aggression; Antisocial Personality Disorder; Area Under Curve; Attention Deficit | 2007 |
Serotonin function in detoxified heroin abusers: prolactin and cortisol responses to fenfluramine challenge.
Topics: Adult; Aggression; Antisocial Personality Disorder; Depressive Disorder; Fenfluramine; Heroin Depend | 1995 |
Serotonergic function in mothers of opioid addicts: correlation with comorbid depression.
Topics: Adult; Aggression; Analysis of Variance; Antisocial Personality Disorder; Case-Control Studies; Code | 1997 |
Blunted prolactin responses to d-fenfluramine in sociopathy. Evidence for subsensitivity of central serotonergic function.
Topics: Adult; Antisocial Personality Disorder; Fenfluramine; Homicide; Humans; Insanity Defense; Male; Prol | 1992 |