fenfluramine has been researched along with Anorexia in 39 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Anorexia: The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that lesions of the medial parabrachial nucleus (PBN) enhanced d-fenfluramine (DFEN)-induced anorexia; a finding that suggests these lesions may potentiate the release of serotonin (5HT) or increase the postsynaptic action of 5HT." | 7.73 | Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors. ( Reilly, S; Trifunovic, R, 2006) |
| "Previously, we have shown that repeated administration of d-fenfluramine (D-F) to rats is associated with development of tolerance to the initial anorexia, but that in mice no such tolerance seems to occur." | 7.72 | Relationship between anorexia and loss of serotonin uptake sites in brain of mice and rats receiving d-norfenfluramine or d-fenfluramine. ( Green, DJ; Robertson, K; Rokadia, S; Rowland, NE, 2004) |
| " The present study compared the patterns of c-fos protein-like immunoreactivity (FLI) induced in rat brain by CCK and the indirect 5HT agonist dexfenfluramine (DFEN), as well as the ability for devazepide, a CCK-A receptor antagonist, to antagonize both anorexia and FLI induced by these agents." | 7.69 | Cholecystokinin- and dexfenfluramine-induced anorexia compared using devazepide and c-fos expression in the rat brain. ( Li, BH; Rowland, NE, 1994) |
| "These studies investigated the involvement of the 5-HT1A receptor in mediating d-fenfluramine-induced anorexia in the rat." | 7.69 | Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtype. ( Clifton, PG; Dourish, CT; Vickers, SP, 1996) |
| " Equivalent levels of anorexia induced by fenfluramine and mazindol were similarly antagonized by methysergide in a dose-related manner." | 7.65 | Inhibition of drug-induced anorexia in rats by methysergide. ( Barrett, AM; McSharry, L, 1975) |
| " In recently published randomized controlled trials, fenfluramine (FFA) proved to be safe and effective in DS." | 6.94 | Efficacy and safety of Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: A real-world study. ( Battaglia, D; Cossu, A; Dalla Bernardina, B; Darra, F; Doccini, V; Granata, T; Guerrini, R; Luigia Gambardella, M; Mei, D; Pietrafusa, N; Quintiliani, M; Ragona, F; Rosati, A; Specchio, N; Spolverato, S; Trivisano, M; Vigevano, F, 2020) |
| " The threshold dose was two to three times higher in CD rats than in their intact controls, but the dynamic range of the dose-response curves of the two groups were overlapping with similar slopes of decline and with comparable maximal intake suppression." | 5.30 | Contribution of caudal brainstem to d-fenfluramine anorexia. ( Donahey, JC; Grill, HJ; Kaplan, JM; King, L, 1997) |
| "We previously reported that lesions of the medial parabrachial nucleus (PBN) enhanced d-fenfluramine (DFEN)-induced anorexia; a finding that suggests these lesions may potentiate the release of serotonin (5HT) or increase the postsynaptic action of 5HT." | 3.73 | Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors. ( Reilly, S; Trifunovic, R, 2006) |
| " The selective effects of OEA in free-feeding rats are strikingly different from those of the serotonergic anorexiant d-fenfluramine (which delayed feeding and reduced meal size) and the intestinal peptide cholecystokinin (which reduced meal size)." | 3.72 | Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. ( Gaetani, S; Oveisi, F; Piomelli, D, 2003) |
| "These studies investigated the involvement of the 5-HT1A receptor in mediating d-fenfluramine-induced anorexia in the rat." | 3.69 | Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtype. ( Clifton, PG; Dourish, CT; Vickers, SP, 1996) |
| " Equivalent levels of anorexia induced by fenfluramine and mazindol were similarly antagonized by methysergide in a dose-related manner." | 3.65 | Inhibition of drug-induced anorexia in rats by methysergide. ( Barrett, AM; McSharry, L, 1975) |
| " In recently published randomized controlled trials, fenfluramine (FFA) proved to be safe and effective in DS." | 2.94 | Efficacy and safety of Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: A real-world study. ( Battaglia, D; Cossu, A; Dalla Bernardina, B; Darra, F; Doccini, V; Granata, T; Guerrini, R; Luigia Gambardella, M; Mei, D; Pietrafusa, N; Quintiliani, M; Ragona, F; Rosati, A; Specchio, N; Spolverato, S; Trivisano, M; Vigevano, F, 2020) |
| " The threshold dose was two to three times higher in CD rats than in their intact controls, but the dynamic range of the dose-response curves of the two groups were overlapping with similar slopes of decline and with comparable maximal intake suppression." | 1.30 | Contribution of caudal brainstem to d-fenfluramine anorexia. ( Donahey, JC; Grill, HJ; Kaplan, JM; King, L, 1997) |
| "Like devazepide, IQM-95,333 was a more potent antagonist of CCK-8S- than of CCK-4-induced contraction of the longitudinal muscle from guinea-pig ileum, suggesting selective antagonism at CCKA receptors." | 1.30 | Pharmacological evaluation of IQM-95,333, a highly selective CCKA receptor antagonist with anxiolytic-like activity in animal models. ( Ballaz, S; Barber, A; Del Río, J; Fortuño, A; García-López, MT; Gómez-Monterrey, I; González-Muñiz, R; Herranz, R; Martin-Martínez, M, 1997) |
| "Fenfluramine + phentermine was a widely used combination for weight loss." | 1.30 | Anorectic efficacy of the fenfluramine/phentermine combination in rats: additivity or synergy? ( Roth, JD; Rowland, NE, 1999) |
| "Treatment with fenfluramine or fluoxetine increased post-fasting anorexia, abolished the preference for carbohydrates and decreased lipid intake." | 1.29 | Effect of activation of the serotoninergic system during prolonged starvation on subsequent caloric intake and macronutrient selection in the Zucker rat. ( Duhault, J; Espinal, J; Lacour, F; Rolland, Y, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (41.03) | 18.7374 |
| 1990's | 13 (33.33) | 18.2507 |
| 2000's | 8 (20.51) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Specchio, N | 1 |
| Pietrafusa, N | 1 |
| Doccini, V | 1 |
| Trivisano, M | 1 |
| Darra, F | 1 |
| Ragona, F | 1 |
| Cossu, A | 1 |
| Spolverato, S | 1 |
| Battaglia, D | 1 |
| Quintiliani, M | 1 |
| Luigia Gambardella, M | 1 |
| Rosati, A | 1 |
| Mei, D | 1 |
| Granata, T | 1 |
| Dalla Bernardina, B | 1 |
| Vigevano, F | 1 |
| Guerrini, R | 1 |
| Xu, Y | 1 |
| Jones, JE | 1 |
| Lauzon, DA | 1 |
| Anderson, JG | 1 |
| Balthasar, N | 1 |
| Heisler, LK | 1 |
| Zinn, AR | 1 |
| Lowell, BB | 1 |
| Elmquist, JK | 1 |
| Gaetani, S | 1 |
| Oveisi, F | 1 |
| Piomelli, D | 1 |
| Rowland, NE | 4 |
| Rokadia, S | 1 |
| Green, DJ | 1 |
| Robertson, K | 1 |
| Atchley, DP | 1 |
| Eckel, LA | 2 |
| Rivera, HM | 1 |
| Trifunovic, R | 2 |
| Reilly, S | 2 |
| Hillebrand, JJ | 1 |
| Heinsbroek, AC | 1 |
| Kas, MJ | 1 |
| Adan, RA | 1 |
| Silverstone, T | 2 |
| Carlton, J | 2 |
| Rowland, N | 1 |
| Samanin, R | 2 |
| Caccia, S | 1 |
| Bendotti, C | 1 |
| Borsini, F | 1 |
| Borroni, E | 1 |
| Invernizzi, R | 1 |
| Pataccini, R | 1 |
| Mennini, T | 2 |
| Leshem, M | 1 |
| Garattini, S | 1 |
| McCann, UD | 2 |
| Yuan, J | 2 |
| Ricaurte, GA | 2 |
| Li, BH | 1 |
| Rieg, TS | 1 |
| Maestrello, AM | 1 |
| Aravich, PF | 1 |
| Duhault, J | 1 |
| Lacour, F | 1 |
| Espinal, J | 1 |
| Rolland, Y | 1 |
| Vickers, SP | 1 |
| Clifton, PG | 1 |
| Dourish, CT | 1 |
| Grill, HJ | 1 |
| Donahey, JC | 1 |
| King, L | 1 |
| Kaplan, JM | 1 |
| Hatzidimitriou, G | 1 |
| Ballaz, S | 1 |
| Barber, A | 1 |
| Fortuño, A | 1 |
| Del Río, J | 1 |
| Martin-Martínez, M | 1 |
| Gómez-Monterrey, I | 1 |
| Herranz, R | 1 |
| González-Muñiz, R | 1 |
| García-López, MT | 1 |
| Fasciano, J | 1 |
| Steele, T | 1 |
| Castagnoli, N | 1 |
| Katz, J | 1 |
| Ricaurte, G | 1 |
| Lucas, JJ | 1 |
| Yamamoto, A | 1 |
| Scearce-Levie, K | 1 |
| Saudou, F | 1 |
| Hen, R | 1 |
| Currie, PJ | 1 |
| Coscina, DV | 1 |
| Fletcher, PJ | 2 |
| Roth, JD | 1 |
| Voigt, JP | 1 |
| Wenz, D | 1 |
| Voits, M | 1 |
| Fink, H | 1 |
| Barrett, AM | 1 |
| McSharry, L | 1 |
| Sugrue, MF | 1 |
| Goodlet, I | 1 |
| McIndewar, I | 1 |
| Antelman, SM | 1 |
| Caggiula, AR | 1 |
| Black, CA | 1 |
| Edwards, DJ | 1 |
| Förster, H | 1 |
| Huth, K | 1 |
| Koch, E | 1 |
| Tunali, G | 1 |
| Clark, JM | 1 |
| Clark, AJ | 1 |
| Winn, P | 1 |
| Stallone, D | 1 |
| Nicolaïdis, S | 1 |
| Gibbs, J | 1 |
| Burton, MJ | 1 |
| Wolgin, DL | 1 |
| Oslan, IA | 1 |
| Thompson, GB | 1 |
| Goodall, E | 1 |
| Hewson, G | 1 |
| Leighton, GE | 1 |
| Hill, RG | 1 |
| Hughes, J | 1 |
| Majeed, NH | 1 |
| Lasoń, W | 1 |
| Przewłocka, B | 1 |
| Przewłocki, R | 1 |
2 reviews available for fenfluramine and Anorexia
| Article | Year |
|---|---|
The clinical pharmacology of appetite--its relevance to psychiatry.
Topics: Amphetamine; Anorexia; Appetite; Bipolar Disorder; Brain Chemistry; Depressive Disorder; Dopamine; F | 1983 |
Neurobiology of an anorectic drug: fenfluramine.
Topics: Acute Disease; Adipose Tissue; Animals; Anorexia; Arousal; Avoidance Learning; Behavior Therapy; Bod | 1986 |
1 trial available for fenfluramine and Anorexia
| Article | Year |
|---|---|
Efficacy and safety of Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: A real-world study.
Topics: Adolescent; Adult; Anorexia; Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Female | 2020 |
36 other studies available for fenfluramine and Anorexia
| Article | Year |
|---|---|
A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.
Topics: Animals; Anorexia; Fenfluramine; Male; Melanocortins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neur | 2010 |
Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide.
Topics: Animals; Anorexia; Appetite Depressants; Behavior, Animal; Dose-Response Relationship, Drug; Eating; | 2003 |
Relationship between anorexia and loss of serotonin uptake sites in brain of mice and rats receiving d-norfenfluramine or d-fenfluramine.
Topics: Animals; Anorexia; Brain; Fenfluramine; Mice; Mice, Inbred ICR; Norfenfluramine; Rats; Rats, Sprague | 2004 |
Fenfluramine treatment in female rats accelerates the weight loss associated with activity-based anorexia.
Topics: Animals; Anorexia; Eating; Female; Fenfluramine; Motor Activity; Rats; Rats, Long-Evans; Weight Loss | 2005 |
The anorectic effect of fenfluramine is increased by estradiol treatment in ovariectomized rats.
Topics: Animals; Anorexia; Drug Interactions; Eating; Estradiol; Female; Fenfluramine; Motor Activity; Ovari | 2005 |
Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors.
Topics: Anorexia; Appetite; Energy Intake; Fenfluramine; Ibotenic Acid; Neurons; Piperazines; Pons; Receptor | 2006 |
The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia.
Topics: Animals; Anorexia; Appetite Depressants; Drinking Behavior; Energy Intake; Female; Fenfluramine; In | 2006 |
Anorexia and brain serotonin: development of tolerance to the effects of fenfluramine and quipazine in rats with serotonin-depleting lesions.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Animals; Anorexia; Biogenic Amines; Brain Chemistry; D | 1984 |
Further studies on the mechanism of serotonin-dependent anorexia in rats.
Topics: Animals; Anorexia; Brain; Feeding and Eating Disorders; Feeding Behavior; Female; Fenfluramine; Huma | 1980 |
Morphine-induced anorexia in lateral hypothalamic rats.
Topics: Amphetamine; Animals; Anorexia; Dextroamphetamine; Feeding and Eating Disorders; Fenfluramine; Human | 1981 |
Evidence that it is possible to cause anorexia by increasing release and/or directly stimulating postsynaptic serotonin receptors in the brain.
Topics: Animals; Anorexia; Appetite Depressants; Brain; Feeding Behavior; Fenfluramine; Piperazines; Piperid | 1980 |
Fenfluramine's appetite suppression and serotonin neurotoxicity are separable.
Topics: Animals; Anorexia; Appetite; Body Weight; Drug Combinations; Eating; Fenfluramine; Fluoxetine; Male; | 1995 |
Cholecystokinin- and dexfenfluramine-induced anorexia compared using devazepide and c-fos expression in the rat brain.
Topics: Animals; Anorexia; Benzodiazepinones; Brain; Cholecystokinin; Devazepide; Feeding Behavior; Fenflura | 1994 |
Weight cycling alters the effects of D-fenfluramine on susceptibility to activity-based anorexia.
Topics: Animals; Anorexia; Body Weight; Eating; Fenfluramine; Male; Physical Exertion; Rats; Rats, Sprague-D | 1994 |
Effect of activation of the serotoninergic system during prolonged starvation on subsequent caloric intake and macronutrient selection in the Zucker rat.
Topics: Animals; Anorexia; Dietary Carbohydrates; Energy Intake; Fenfluramine; Fluoxetine; Food Preferences; | 1993 |
Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT1A receptor subtype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anorexia; Appetite Depressants; Appetitive Behavior | 1996 |
Contribution of caudal brainstem to d-fenfluramine anorexia.
Topics: Animals; Anorexia; Appetite Depressants; Brain Stem; Decerebrate State; Fenfluramine; Male; Rats; Ra | 1997 |
Selective serotonin reuptake inhibitors dissociate fenfluramine's anorectic and neurotoxic effects: importance of dose, species and drug.
Topics: Animals; Anorexia; Brain; Fenfluramine; Male; Mice; Neurotoxins; Rats; Rats, Sprague-Dawley; Selecti | 1997 |
Pharmacological evaluation of IQM-95,333, a highly selective CCKA receptor antagonist with anxiolytic-like activity in animal models.
Topics: Amylases; Animals; Anorexia; Anti-Anxiety Agents; Benzodiazepinones; Carbamates; Cholecystokinin; De | 1997 |
The effect of N-methylation on fenfluramine's neurotoxic and pharmacologic actions.
Topics: Animals; Anorexia; Appetite Depressants; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Dose-Re | 1997 |
Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice.
Topics: Amygdala; Animals; Anorexia; Appetite Depressants; Body Weight; Drug Evaluation, Preclinical; Feedin | 1998 |
Reversal of fenfluramine and fluoxetine anorexia by 8-OH-DPAT is attenuated following raphe injection of 5,7-dihydroxytryptamine.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anorexia; Brain; Corpus St | 1998 |
Anorectic efficacy of the fenfluramine/phentermine combination in rats: additivity or synergy?
Topics: Animals; Anorexia; Appetite Depressants; Dexfenfluramine; Dose-Response Relationship, Drug; Drug Com | 1999 |
Does increased endogenous CCK interact with serotonin to reduce food intake in rats?
Topics: Animals; Anorexia; Body Weight; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions | 2000 |
Medial versus lateral parabrachial nucleus lesions in the rat: effects on cholecystokinin- and D-fenfluramine-induced anorexia.
Topics: Animals; Anorexia; Cholecystokinin; Eating; Excitatory Amino Acid Agonists; Feedback; Fenfluramine; | 2001 |
Inhibition of drug-induced anorexia in rats by methysergide.
Topics: Animals; Anorexia; Appetite; Brain Chemistry; Eating; Fenfluramine; Iproniazid; Male; Mazindol; Meth | 1975 |
Failure of depletion of rat brain 5-hydroxytryptamine to alter fenfluramine-induced anorexia.
Topics: 5,6-Dihydroxytryptamine; Animals; Anorexia; Appetite; Brain; Depression, Chemical; Dopamine; Fenclon | 1975 |
Stress reverse the anorexia induced by amphetamine and methylphenidate but not fenfluramine.
Topics: Animals; Anorexia; Dextroamphetamine; Dose-Response Relationship, Drug; Feeding and Eating Disorders | 1978 |
[Is fenfluramine a suitable therapeutic principle in obese aged diabetics?].
Topics: Adult; Aged; Aging; Animals; Anorexia; Diabetes Complications; Fenfluramine; Humans; Lactates; Male; | 1979 |
N-methyl-D-aspartate lesions of the lateral hypothalamus do not reduce amphetamine or fenfluramine anorexia but enhance the acquisition of eating in response to tail pinch in the rat.
Topics: Amphetamine; Analysis of Variance; Animals; Anorexia; Feeding Behavior; Fenfluramine; Hypothalamic A | 1992 |
Cholecystokinin-induced anorexia depends on serotoninergic function.
Topics: Amidines; Animals; Anorexia; Cholecystokinin; Dose-Response Relationship, Drug; Eating; Feeding and | 1989 |
Dissociation of the anorectic actions of 5-HTP and fenfluramine.
Topics: Amidines; Animals; Anorexia; Appetite Depressants; Eating; Fenfluramine; Male; Rats; Receptors, Sero | 1986 |
Effects of "anorexia" on appetitive and consummatory behavior.
Topics: Amphetamine; Animals; Anorexia; Appetite; Feeding and Eating Disorders; Feeding Behavior; Fenflurami | 1988 |
Differential effect of d-fenfluramine and metergoline on food intake in human subjects.
Topics: Adolescent; Adult; Anorexia; Appetite; Eating; Ergolines; Fenfluramine; Humans; Male; Metergoline; S | 1988 |
Ketanserin antagonises the anorectic effect of DL-fenfluramine in the rat.
Topics: Animals; Anorexia; Fenfluramine; Ketanserin; Male; Prazosin; Rats; Receptors, Adrenergic; Receptors, | 1988 |
Involvement of endogenous opioid peptides in fenfluramine anorexia.
Topics: Animals; Anorexia; Body Weight; Duodenum; Endorphins; Feeding and Eating Disorders; Feeding Behavior | 1986 |