fenfluramine has been researched along with Anorexia Nervosa in 15 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Anorexia Nervosa: An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Unlike the control subjects, those recovered from anorexia nervosa did not show the expected appetite-suppressing responses to d-fenfluramine; their eating attitudes and behaviour were more restrained, 'negative' perfectionism was more pronounced, and post-meal plasma cortisol levels did not rise as expected." | 9.08 | Neuroendocrine, appetitive and behavioural responses to d-fenfluramine in women recovered from anorexia nervosa. ( Brown, N; Campbell, IC; Lightman, S; Treasure, J; Ward, A, 1998) |
| "A double-blind, placebo-controlled trial of d-fenfluramine in bulimia nervosa was undertaken in order to assess its efficacy in controlling bulimic behavior and relieving more general symptoms." | 9.06 | A controlled trial of d-fenfluramine in bulimia nervosa. ( Checkley, SA; Eisler, I; Feldman, J; Russell, GF, 1988) |
| "of D-fenfluramine were measured over a 5 h period." | 5.29 | Serotonin activity in anorexia nervosa after long-term weight restoration: response to D-fenfluramine challenge. ( Lucey, JV; O'Dwyer, AM; Russell, GF, 1996) |
| "A double-blind, placebo-controlled trial of d-fenfluramine in bulimia nervosa was undertaken in order to assess its efficacy in controlling bulimic behavior and relieving more general symptoms." | 5.06 | A controlled trial of d-fenfluramine in bulimia nervosa. ( Checkley, SA; Eisler, I; Feldman, J; Russell, GF, 1988) |
| "Fenfluramine has the potential to be of therapeutic value in patients with bulimia." | 2.38 | The role of pharmacotherapy in anorexia nervosa and bulimia. ( Tolstoi, LG, 1989) |
| "Increased research focusing on the eating disorders has put the clinician on firmer ground when choosing appropriate psychopharmacologic treatments." | 2.37 | Pharmacologic treatment of eating disorders. ( Gwirtsman, H; Jimerson, DC; Kaye, W; Weintraub, M, 1984) |
| "of D-fenfluramine were measured over a 5 h period." | 1.29 | Serotonin activity in anorexia nervosa after long-term weight restoration: response to D-fenfluramine challenge. ( Lucey, JV; O'Dwyer, AM; Russell, GF, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (53.33) | 18.7374 |
| 1990's | 5 (33.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gwirtsman, H | 1 |
| Kaye, W | 1 |
| Weintraub, M | 1 |
| Jimerson, DC | 2 |
| O'Dwyer, AM | 1 |
| Lucey, JV | 1 |
| Russell, GF | 3 |
| Gupta, D | 1 |
| Rizvi, A | 1 |
| Mannari, JG | 1 |
| Ward, A | 1 |
| Brown, N | 1 |
| Lightman, S | 1 |
| Campbell, IC | 1 |
| Treasure, J | 1 |
| Monteleone, P | 2 |
| Brambilla, F | 3 |
| Bortolotti, F | 2 |
| La Rocca, A | 1 |
| Maj, M | 2 |
| Bellodi, L | 1 |
| Arancio, C | 1 |
| Limonta, D | 1 |
| Ferrari, E | 1 |
| Solerte, B | 1 |
| Lesem, MD | 1 |
| Hegg, AP | 1 |
| Brewerton, TD | 1 |
| Tolstoi, LG | 1 |
| Checkley, SA | 2 |
| Feldman, J | 1 |
| Eisler, I | 1 |
| Robinson, PH | 1 |
| Kaufmann, NA | 1 |
| Blondheim, SH | 1 |
| Leibowitz, SF | 1 |
| Abdel-Kader, MM | 1 |
| Mashaly, M | 1 |
| Abdel-Aziz, MT | 1 |
| Mirsky, SS | 1 |
3 reviews available for fenfluramine and Anorexia Nervosa
| Article | Year |
|---|---|
Pharmacologic treatment of eating disorders.
Topics: Anorexia Nervosa; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Central | 1984 |
Serotonin in human eating disorders.
Topics: Anorexia Nervosa; Bulimia; Feeding and Eating Disorders; Feeding Behavior; Fenfluramine; Humans; Ser | 1990 |
The role of pharmacotherapy in anorexia nervosa and bulimia.
Topics: Anorexia Nervosa; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bulimia; Clomiphene; Coun | 1989 |
6 trials available for fenfluramine and Anorexia Nervosa
| Article | Year |
|---|---|
Neuroendocrine, appetitive and behavioural responses to d-fenfluramine in women recovered from anorexia nervosa.
Topics: Adult; Anorexia Nervosa; Appetite Depressants; Attitude to Health; Feeding Behavior; Female; Fenflur | 1998 |
Prolactin response to d-fenfluramine is blunted in people with anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Double-Blind Method; Estradiol; Female; Fenfluramine; Humans; P | 1998 |
Neurotransmitter and hormonal background of hostility in anorexia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Area Under Curve; Body Mass Index; Estrogens; Female; Fenfluram | 2001 |
Serotonergic dysfunction across the eating disorders: relationship to eating behaviour, purging behaviour, nutritional status and general psychopathology.
Topics: Adult; Anorexia Nervosa; Bulimia; Double-Blind Method; Feeding Behavior; Female; Fenfluramine; Human | 2000 |
A controlled trial of d-fenfluramine in bulimia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Attitude; Body Weight; Bulimia; Clinical Trials as Topic; Depre | 1988 |
Suppression of eating by fenfluramine in patients with bulimia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Depression, Chemical; Eating; Feeding and Eating Disorders; Fem | 1985 |
6 other studies available for fenfluramine and Anorexia Nervosa
| Article | Year |
|---|---|
Serotonin activity in anorexia nervosa after long-term weight restoration: response to D-fenfluramine challenge.
Topics: Administration, Oral; Adult; Anorexia Nervosa; Body Weight; Comorbidity; Female; Fenfluramine; Follo | 1996 |
Poisoning with fenfluramine.
Topics: Adult; Anorexia Nervosa; Appetite Depressants; Female; Fenfluramine; Humans | 1996 |
Action of fenfluramine.
Topics: Anorexia Nervosa; Body Weight; Fenfluramine; Humans; Male; Obesity | 1973 |
Central adrenergic receptors and the regulation of hunger and thirst.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1972 |
Clinical and biochemical studies on obese subjects using fenfluramine.
Topics: Anorexia Nervosa; Blood Pressure; Diarrhea; Fatigue; Female; Fenfluramine; Glucose Tolerance Test; H | 1974 |
[The fenfluramine as an ideal anorexigenic for young people in school age].
Topics: Adolescent; Anorexia Nervosa; Appetite Depressants; Child; Child, Preschool; Fenfluramine; Fluorine; | 1968 |