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fenfluramine and Angiogenesis, Pathologic

fenfluramine has been researched along with Angiogenesis, Pathologic in 1 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research Excerpts

ExcerptRelevanceReference
" Body weight, insulin, and leptin were decreased (p < 0."3.76MR molecular imaging of aortic angiogenesis. ( Cai, K; Caruthers, SD; Huang, W; Lanza, GM; Wickline, SA; Williams, TA; Winter, PM; Zhang, H, 2010)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cai, K1
Caruthers, SD1
Huang, W1
Williams, TA1
Zhang, H1
Wickline, SA1
Lanza, GM1
Winter, PM1

Other Studies

1 other study available for fenfluramine and Angiogenesis, Pathologic

ArticleYear
MR molecular imaging of aortic angiogenesis.
    JACC. Cardiovascular imaging, 2010, Volume: 3, Issue:8

    Topics: Animals; Aorta; Appetite Depressants; Atherosclerosis; Body Weight; Cholesterol; Disease Models, Ani

2010