fenfluramine has been researched along with Anemia, Hemolytic in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Anemia, Hemolytic: A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Precapillary pulmonary hypertension is defined by an increase in mPAP > or =25 mmHg and a pulmonary capillary wedge pressure (PCWP)< or =15 mmHg associated with a normal or reduced cardiac output." | 1.36 | [Diagnosis and classification of pulmonary hypertension]. ( Chaouat, A; Montani, D, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Montani, D | 1 |
| Chaouat, A | 1 |
| Burland, WL | 1 |
| Nussey, AM | 1 |
3 other studies available for fenfluramine and Anemia, Hemolytic
| Article | Year |
|---|---|
[Diagnosis and classification of pulmonary hypertension].
Topics: Activin Receptors, Type II; Anemia, Hemolytic; Bone Morphogenetic Protein Receptors, Type II; Cardia | 2010 |
Fenfluramine and haemolytic anaemia.
Topics: Anemia, Hemolytic; Female; Fenfluramine; Humans; Middle Aged | 1973 |
Fenfluramine and haemolytic anaemia.
Topics: Anemia, Hemolytic; Female; Fenfluramine; Humans; Middle Aged; Obesity | 1973 |