fenfluramine has been researched along with Alloxan Diabetes in 9 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have examined the effect of chronic (20 days) oral administration of benfluorex (35 mg/kg) in a rat model of NIDDM, induced by injection of STZ 5 days after birth and characterized by frank hyperglycemia, hypoinsulinemia, and hepatic and peripheral insulin resistance." | 7.68 | Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats. ( Bailbe, D; Blondel, O; Portha, B; Serradas, P, 1993) |
| "We have examined the effect of chronic (21 days) oral administration of the serotoninergic anorectic drug d-fenfluramine (5 mg/kg) in a rat model of non-insulin-dependent diabetes (without obesity), as induced by injection of a low dose (45 mg/kg) of streptozotocin at 6 weeks, and characterized by marked hyperglycaemia and hepatic and peripheral insulin resistance." | 3.69 | d-Fenfluramine improves hepatic insulin action in streptozotocin-diabetic rats. ( Bailbé, D; Picarel-Blanchot, F; Portha, B, 1994) |
| "We have examined the effect of chronic (20 days) oral administration of benfluorex (35 mg/kg) in a rat model of NIDDM, induced by injection of STZ 5 days after birth and characterized by frank hyperglycemia, hypoinsulinemia, and hepatic and peripheral insulin resistance." | 3.68 | Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats. ( Bailbe, D; Blondel, O; Portha, B; Serradas, P, 1993) |
| "Dexfenfluramine has been shown to lower blood glucose concentrations independently of its effects in reducing food intake and body weight, in human and animal syndromes of non-insulin dependent diabetes." | 1.29 | Acute dexfenfluramine administration normalizes glucose tolerance in rats with insulin-deficient diabetes. ( Arora, R; Dryden, S; McKibbin, PE; Williams, G, 1994) |
| "Benfluorex treatment to some extent prevented the decrease in GLUT4 protein in white and brown adipose tissue and in white muscle associated with diabetes." | 1.29 | Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats. ( Camps, M; Castelló, A; Chillarón, J; Furriols, M; Muñoz, P; Palacín, M; Testar, X; Zorzano, A, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sari Kiliçaslan, SM | 1 |
| Ozer, C | 1 |
| Picarel-Blanchot, F | 1 |
| Bailbé, D | 3 |
| Portha, B | 3 |
| Arora, R | 1 |
| Dryden, S | 1 |
| McKibbin, PE | 1 |
| Williams, G | 1 |
| Serradas, P | 2 |
| Blondel, O | 2 |
| Picarel, F | 1 |
| Muñoz, P | 1 |
| Chillarón, J | 1 |
| Camps, M | 1 |
| Castelló, A | 1 |
| Furriols, M | 1 |
| Testar, X | 1 |
| Palacín, M | 1 |
| Zorzano, A | 1 |
| Giraudet-Wentz, MC | 1 |
| Duhault, J | 1 |
| Boulander, M | 1 |
| Beregi, L | 1 |
| el-Refai, MF | 1 |
| Chan, TM | 1 |
9 other studies available for fenfluramine and Alloxan Diabetes
| Article | Year |
|---|---|
Effects of benfluorex-vitamin C supplementation on cutaneous capillaries of diabetic rats.
Topics: Animals; Ascorbic Acid; Capillaries; Dermis; Diabetes Mellitus, Experimental; Dietary Supplements; D | 2009 |
d-Fenfluramine improves hepatic insulin action in streptozotocin-diabetic rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; | 1994 |
Acute dexfenfluramine administration normalizes glucose tolerance in rats with insulin-deficient diabetes.
Topics: Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental; Dose-Response Relationship, | 1994 |
Effect of benfluorex on insulin secretion and insulin action in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fenfluramine; Gl | 1993 |
Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Fenflura | 1993 |
Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats.
Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Fenfluramine; Glucose Transporter Type 4; | 1996 |
[Effects of mediator of glucose metabolism: pharmacological and clinical synthesis].
Topics: Animals; Diabetes Mellitus, Experimental; Fenfluramine; Glucose; Hyperglycemia; Insulin; Lipid Metab | 1979 |
Pharmacological effects of 780SE (992) on hyperlipidaemic and obese rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Female; Fenfluram | 1975 |
Possible involvement of a hypothalamic dopaminergic receptor in development of genetic obesity in mice.
Topics: Adenylyl Cyclases; Amphetamines; Animals; Ascorbic Acid; Aurothioglucose; Catechols; Diabetes Mellit | 1986 |