fenfluramine has been researched along with Alcohol Drinking in 16 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of the serotonin receptor agonist dexfenfluramine on eating habits and weight loss in ambulatory, android type, moderately obese patients with an overconsumption of snacks." | 5.08 | The effect of dexfenfluramine on eating habits in a Dutch ambulatory android overweight population with an overconsumption of snacks. ( Drent, ML; Koppeschaar, HP; Lutterman, JA; Nieuwenhuyzen Kruseman, AC; van der Veen, EA; Zelissen, PM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 9 (56.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| West, CH | 1 |
| Boss-Williams, KA | 1 |
| Weiss, JM | 1 |
| Drent, ML | 1 |
| Zelissen, PM | 1 |
| Koppeschaar, HP | 1 |
| Nieuwenhuyzen Kruseman, AC | 1 |
| Lutterman, JA | 1 |
| van der Veen, EA | 1 |
| Rezvani, AH | 1 |
| Grady, DR | 1 |
| Lu, MR | 3 |
| Wagner, GC | 6 |
| Fisher, H | 6 |
| Rothman, RB | 1 |
| Halladay, AK | 2 |
| Hsu, T | 1 |
| Sekowski, A | 1 |
| Wilson, AW | 1 |
| Costall, B | 1 |
| Neill, JC | 1 |
| Berggren, U | 1 |
| Eriksson, M | 1 |
| Fahlke, C | 1 |
| Balldin, J | 1 |
| Krasner, N | 1 |
| Moore, MR | 1 |
| Dow, J | 1 |
| Thompson, GG | 1 |
| Goldberg, A | 1 |
| Sellers, EM | 1 |
| Higgins, GA | 1 |
| Tompkins, DM | 1 |
| Romach, MK | 1 |
| Hsu, HC | 1 |
| Opitz, K | 1 |
| Wilson, CW | 1 |
1 review available for fenfluramine and Alcohol Drinking
| Article | Year |
|---|---|
The pharmacological actions of alcohol in relation to nutrition.
Topics: Absorption; Adult; Alcohol Drinking; Animals; Barbiturates; Behavior, Animal; Diffusion; Disulfiram; | 1972 |
2 trials available for fenfluramine and Alcohol Drinking
| Article | Year |
|---|---|
The effect of dexfenfluramine on eating habits in a Dutch ambulatory android overweight population with an overconsumption of snacks.
Topics: Adult; Alcohol Drinking; Ambulatory Care; Dietary Carbohydrates; Double-Blind Method; Eating; Feedin | 1995 |
Serotonin and alcohol drinking.
Topics: 1-Naphthylamine; Adult; Alcohol Drinking; Alcoholism; Animals; Double-Blind Method; Fenfluramine; Hu | 1992 |
13 other studies available for fenfluramine and Alcohol Drinking
| Article | Year |
|---|---|
Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Antidepressive Agents, Second-Gen | 2011 |
Suppression of alcohol consumption by fenfluramine in Fawn-Hooded rats with serotonin dysfunction.
Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking; Eating; E | 1994 |
Ethanol consumption following acute treatment with methysergide, fluoxetine, fenfluramine, and their combination.
Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Male; Methyse | 1994 |
Ethanol consumption following acute fenfluramine, fluoxetine, and dietary tryptophan.
Topics: Alcohol Drinking; Animals; Diet; Dose-Response Relationship, Drug; Drinking Behavior; Energy Intake; | 1993 |
Smoking cessation in a patient being treated with fenfluramine plus phentermine for simple obesity.
Topics: Adult; Alcohol Drinking; Comorbidity; Drug Therapy, Combination; Fenfluramine; Humans; Male; Obesity | 1996 |
Differential effects of monoaminergic agonists on alcohol intake in rats fed a tryptophan-enhanced diet.
Topics: Alcohol Drinking; Amphetamine; Animals; Appetite Depressants; Cerebral Cortex; Corpus Striatum; Dopa | 1999 |
Effects of phentermine and fenfluramine on alcohol consumption and alcohol withdrawal seizures in rats.
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Animals; Appetite Depressants; Drug Interactions; Dru | 2000 |
Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Amphetamines; Animals; Buspirone; Conditio | 2000 |
Relationship between central serotonergic neurotransmission and reduction in alcohol intake by citalopram.
Topics: Adult; Alcohol Drinking; Citalopram; Cross-Over Studies; Double-Blind Method; Fenfluramine; Humans; | 2001 |
Fenfluramine and 780SE in experimental alcoholism in rats.
Topics: Alcohol Drinking; Alcohol Oxidoreductases; Animals; Body Weight; Fenfluramine; Liver; Male; Porphobi | 1975 |
Ethanol intake of chickens treated with fenfluramine, fluoxetine, and dietary tryptophan.
Topics: Alcohol Drinking; Animals; Body Temperature Regulation; Brain; Chickens; Dose-Response Relationship, | 1992 |
Suppression of ethanol intake in chickens by fenfluramine and dietary tryptophan.
Topics: Alcohol Drinking; Animals; Body Temperature Regulation; Brain; Chickens; Dose-Response Relationship, | 1991 |
Effect of fennfluramine on alcohol and saccharin consumption in the rat.
Topics: Alcohol Drinking; Animals; Drinking Behavior; Fenclonine; Fenfluramine; Injections, Intraperitoneal; | 1972 |