Page last updated: 2024-10-26

fenfluramine and Alcohol Drinking

fenfluramine has been researched along with Alcohol Drinking in 16 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effect of the serotonin receptor agonist dexfenfluramine on eating habits and weight loss in ambulatory, android type, moderately obese patients with an overconsumption of snacks."5.08The effect of dexfenfluramine on eating habits in a Dutch ambulatory android overweight population with an overconsumption of snacks. ( Drent, ML; Koppeschaar, HP; Lutterman, JA; Nieuwenhuyzen Kruseman, AC; van der Veen, EA; Zelissen, PM, 1995)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19903 (18.75)18.7374
1990's9 (56.25)18.2507
2000's3 (18.75)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
West, CH1
Boss-Williams, KA1
Weiss, JM1
Drent, ML1
Zelissen, PM1
Koppeschaar, HP1
Nieuwenhuyzen Kruseman, AC1
Lutterman, JA1
van der Veen, EA1
Rezvani, AH1
Grady, DR1
Lu, MR3
Wagner, GC6
Fisher, H6
Rothman, RB1
Halladay, AK2
Hsu, T1
Sekowski, A1
Wilson, AW1
Costall, B1
Neill, JC1
Berggren, U1
Eriksson, M1
Fahlke, C1
Balldin, J1
Krasner, N1
Moore, MR1
Dow, J1
Thompson, GG1
Goldberg, A1
Sellers, EM1
Higgins, GA1
Tompkins, DM1
Romach, MK1
Hsu, HC1
Opitz, K1
Wilson, CW1

Reviews

1 review available for fenfluramine and Alcohol Drinking

ArticleYear
The pharmacological actions of alcohol in relation to nutrition.
    The Proceedings of the Nutrition Society, 1972, Volume: 31, Issue:2

    Topics: Absorption; Adult; Alcohol Drinking; Animals; Barbiturates; Behavior, Animal; Diffusion; Disulfiram;

1972

Trials

2 trials available for fenfluramine and Alcohol Drinking

ArticleYear
The effect of dexfenfluramine on eating habits in a Dutch ambulatory android overweight population with an overconsumption of snacks.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1995, Volume: 19, Issue:5

    Topics: Adult; Alcohol Drinking; Ambulatory Care; Dietary Carbohydrates; Double-Blind Method; Eating; Feedin

1995
Serotonin and alcohol drinking.
    NIDA research monograph, 1992, Volume: 119

    Topics: 1-Naphthylamine; Adult; Alcohol Drinking; Alcoholism; Animals; Double-Blind Method; Fenfluramine; Hu

1992

Other Studies

13 other studies available for fenfluramine and Alcohol Drinking

ArticleYear
Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress.
    Alcohol (Fayetteville, N.Y.), 2011, Volume: 45, Issue:8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Antidepressive Agents, Second-Gen

2011
Suppression of alcohol consumption by fenfluramine in Fawn-Hooded rats with serotonin dysfunction.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 48, Issue:1

    Topics: Alcohol Deterrents; Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Drinking; Eating; E

1994
Ethanol consumption following acute treatment with methysergide, fluoxetine, fenfluramine, and their combination.
    Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:1

    Topics: Alcohol Drinking; Animals; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetine; Male; Methyse

1994
Ethanol consumption following acute fenfluramine, fluoxetine, and dietary tryptophan.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 44, Issue:4

    Topics: Alcohol Drinking; Animals; Diet; Dose-Response Relationship, Drug; Drinking Behavior; Energy Intake;

1993
Smoking cessation in a patient being treated with fenfluramine plus phentermine for simple obesity.
    The Journal of clinical psychiatry, 1996, Volume: 57, Issue:2

    Topics: Adult; Alcohol Drinking; Comorbidity; Drug Therapy, Combination; Fenfluramine; Humans; Male; Obesity

1996
Differential effects of monoaminergic agonists on alcohol intake in rats fed a tryptophan-enhanced diet.
    Alcohol (Fayetteville, N.Y.), 1999, Volume: 18, Issue:1

    Topics: Alcohol Drinking; Amphetamine; Animals; Appetite Depressants; Cerebral Cortex; Corpus Striatum; Dopa

1999
Effects of phentermine and fenfluramine on alcohol consumption and alcohol withdrawal seizures in rats.
    Alcohol (Fayetteville, N.Y.), 2000, Volume: 20, Issue:1

    Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Animals; Appetite Depressants; Drug Interactions; Dru

2000
Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Amphetamines; Animals; Buspirone; Conditio

2000
Relationship between central serotonergic neurotransmission and reduction in alcohol intake by citalopram.
    Drug and alcohol dependence, 2001, Aug-01, Volume: 63, Issue:3

    Topics: Adult; Alcohol Drinking; Citalopram; Cross-Over Studies; Double-Blind Method; Fenfluramine; Humans;

2001
Fenfluramine and 780SE in experimental alcoholism in rats.
    Postgraduate medical journal, 1975, Volume: 51 Suppl 1

    Topics: Alcohol Drinking; Alcohol Oxidoreductases; Animals; Body Weight; Fenfluramine; Liver; Male; Porphobi

1975
Ethanol intake of chickens treated with fenfluramine, fluoxetine, and dietary tryptophan.
    Alcoholism, clinical and experimental research, 1992, Volume: 16, Issue:5

    Topics: Alcohol Drinking; Animals; Body Temperature Regulation; Brain; Chickens; Dose-Response Relationship,

1992
Suppression of ethanol intake in chickens by fenfluramine and dietary tryptophan.
    Alcoholism, clinical and experimental research, 1991, Volume: 15, Issue:6

    Topics: Alcohol Drinking; Animals; Body Temperature Regulation; Brain; Chickens; Dose-Response Relationship,

1991
Effect of fennfluramine on alcohol and saccharin consumption in the rat.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1972, Jun-03, Volume: 46, Issue:23

    Topics: Alcohol Drinking; Animals; Drinking Behavior; Fenclonine; Fenfluramine; Injections, Intraperitoneal;

1972