fenfluramine has been researched along with Aging in 27 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prolactin and cortisol responses to acute challenge with dl-fenfluramine (60 mg PO) were examined in 10 (6 women and 4 men) patients with seasonal affective disorder (SAD) and the same number of age, gender, menstrual status, and season matched healthy controls." | 7.69 | Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder. ( Michalon, M; Yatham, LN, 1995) |
| "It has been reported that benfluorex ameliorates the insulin resistance induced by high-fat feeding when its administration is initiated at the same time as the change in diet." | 3.70 | Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding. ( Gumà, A; Muñoz, P; Palacín, M; Sevilla, L; Testar, X; Zorzano, A, 1999) |
| "Prolactin and cortisol responses to acute challenge with dl-fenfluramine (60 mg PO) were examined in 10 (6 women and 4 men) patients with seasonal affective disorder (SAD) and the same number of age, gender, menstrual status, and season matched healthy controls." | 3.69 | Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder. ( Michalon, M; Yatham, LN, 1995) |
| "We determined the effects of D-fenfluramine treatment on the changes in vascular reactivity induced by aging." | 3.68 | Effect of aging and drug-induced weight reduction on rat vascular reactivity. ( Boulanger, M; Duhault, J; Feletou, M; Moreau, N, 1993) |
| " Treatment once a day for 14 days with 25 mg benfluorex per kg body weight lowered body weight, decreased circulating insulin and resulted in an increase in hepatic glycogen." | 3.68 | Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats. ( Geelen, MJ; Schmitz, MG; Tielens, AG; van den Heuvel, JM, 1993) |
| "To understand some of the mechanisms underlying the neuroendocrine and neurochemical changes associated with aging, we administered the serotonin [5-hydroxytryptamine (5-HT)] releaser and reuptake inhibitor d-fenfluramine (d-FEN; 0." | 3.68 | Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: effects of d-fenfluramine treatment. ( Burgess, LH; Cabrera, TM; Campbell, DB; Cross, MK; George, M; Gordon, BH; Handa, RJ; Hata, N; Lorens, SA, 1993) |
| "Benfluorex treatment lowered diastolic and systolic blood pressures and improved glucose tolerance in both age groups." | 2.68 | Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men. ( Beer, NA; Beer, RM; Colombo, C; Jakubowicz, DJ; Nestler, JE, 1995) |
| "Fenfluramine is an anorectic drug widely used for the regulation of food intake that presents some adverse effects at the central and peripheral levels." | 1.29 | Chronic fenfluramine treatment of rats with different ages: effects on brain oxidative stress-related parameters. ( Azzalis, LA; Camarini, R; Carlini, EA; D'Almeida, V; Junqueira, VB, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.81) | 18.7374 |
| 1990's | 18 (66.67) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Y | 1 |
| Chebolu, S | 1 |
| Skegrud, S | 1 |
| Kamali, S | 1 |
| Darmani, NA | 1 |
| Whitney, KN | 1 |
| Wenger, GR | 1 |
| Burke, LK | 1 |
| Doslikova, B | 1 |
| D'Agostino, G | 1 |
| Garfield, AS | 1 |
| Farooq, G | 1 |
| Burdakov, D | 1 |
| Low, MJ | 1 |
| Rubinstein, M | 1 |
| Evans, ML | 1 |
| Billups, B | 1 |
| Heisler, LK | 1 |
| Leshem, M | 1 |
| Feletou, M | 1 |
| Moreau, N | 1 |
| Boulanger, M | 1 |
| Duhault, J | 1 |
| Nestler, JE | 1 |
| Beer, NA | 1 |
| Jakubowicz, DJ | 1 |
| Colombo, C | 1 |
| Beer, RM | 1 |
| Panksepp, J | 1 |
| Normansell, L | 1 |
| Cox, JF | 1 |
| Siviy, SM | 1 |
| Tielens, AG | 1 |
| van den Heuvel, JM | 1 |
| Schmitz, MG | 1 |
| Geelen, MJ | 1 |
| Handa, RJ | 3 |
| Cross, MK | 1 |
| George, M | 2 |
| Gordon, BH | 3 |
| Burgess, LH | 1 |
| Cabrera, TM | 1 |
| Hata, N | 1 |
| Campbell, DB | 3 |
| Lorens, SA | 3 |
| Yatham, LN | 1 |
| Michalon, M | 1 |
| Clancy, J | 2 |
| Lorens, S | 1 |
| D'Almeida, V | 1 |
| Camarini, R | 1 |
| Azzalis, LA | 1 |
| Junqueira, VB | 1 |
| Carlini, EA | 1 |
| Halperin, JM | 2 |
| Newcorn, JH | 2 |
| Schwartz, ST | 2 |
| Sharma, V | 1 |
| Siever, LJ | 1 |
| Koda, VH | 1 |
| Gabriel, S | 1 |
| Tanum, L | 1 |
| Bråtveit-Johansen, K | 1 |
| Malt, UF | 1 |
| Pick, LH | 1 |
| Sevilla, L | 1 |
| Gumà, A | 1 |
| Muñoz, P | 1 |
| Testar, X | 1 |
| Palacín, M | 1 |
| Zorzano, A | 1 |
| Rozenboim, I | 1 |
| Kapkowska, E | 1 |
| Robinzon, B | 1 |
| Uni, Z | 1 |
| Ramasubbu, R | 1 |
| Flint, A | 1 |
| Brown, G | 1 |
| Awad, G | 1 |
| Kennedy, S | 1 |
| van Amelsvoort, TA | 1 |
| Abel, KM | 1 |
| Robertson, DM | 1 |
| Daly, E | 1 |
| Critchley, H | 1 |
| Whitehead, M | 1 |
| Murphy, DG | 1 |
| Clineschmidt, BV | 1 |
| Zacchei, AG | 1 |
| Totaro, JA | 1 |
| Pflueger, AB | 1 |
| McGuffin, JC | 1 |
| Wishousky, TI | 1 |
| Förster, H | 1 |
| Huth, K | 1 |
| Koch, E | 1 |
| Tunali, G | 1 |
| Bell, J | 1 |
| Zhang, XN | 1 |
| Whitaker-Azmitia, PM | 1 |
| Brindley, DN | 1 |
| Hales, P | 1 |
| al-Sieni, AI | 1 |
| Russell, JC | 1 |
| Petrovic, LM | 1 |
| Thakkar, BK | 1 |
| Dastur, DK | 1 |
| Manghani, DK | 1 |
| Köllner, O | 1 |
| Köllner, U | 1 |
| Göb, R | 1 |
| Klingberg, F | 1 |
4 trials available for fenfluramine and Aging
| Article | Year |
|---|---|
Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men.
Topics: Aged; Aging; Androgens; Blood Glucose; Blood Pressure; Dehydroepiandrosterone; Dehydroepiandrosteron | 1995 |
Age-related changes in the association between serotonergic function and aggression in boys with ADHD.
Topics: Aggression; Aging; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; | 1997 |
Fenfluramine and idiopathic pain: a serotonergic study in non-psychiatric patients with functional gastrointestinal disorder.
Topics: Adult; Aging; Analysis of Variance; Chronic Disease; Female; Fenfluramine; Gastrointestinal Diseases | 1998 |
Neurohormonal responses to D-fenfluramine in healthy elderly subjects. A placebo-controlled study.
Topics: Aged; Aged, 80 and over; Aging; Behavior; Body Weight; Female; Fenfluramine; Hemodynamics; Humans; H | 2000 |
23 other studies available for fenfluramine and Aging
| Article | Year |
|---|---|
Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex.
Topics: Adrenergic Agents; Aging; Animals; Fenfluramine; Humans; Methamphetamine; Mice; Prefrontal Cortex; P | 2023 |
Impulsivity and motor activity in aged, male Ts65Dn mice.
Topics: Aging; Animals; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Disease | 2013 |
5-HT obesity medication efficacy via POMC activation is maintained during aging.
Topics: Aging; Animals; Female; Fenfluramine; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesit | 2014 |
Ontogeny of fenfluramine and amphetamine anorexia compared in rat pups.
Topics: Aging; Amphetamine; Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Fenfluramine; Mu | 1981 |
Effect of aging and drug-induced weight reduction on rat vascular reactivity.
Topics: Administration, Oral; Aging; Animals; Aorta; Blood Glucose; Body Weight; Endothelium, Vascular; Fenf | 1993 |
Effects of neonatal decortication on the social play of juvenile rats.
Topics: Aging; Animals; Animals, Newborn; Appetitive Behavior; Brain Mapping; Cerebral Cortex; Cerebral Deco | 1994 |
Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats.
Topics: Aging; Animals; Body Weight; Fenfluramine; Glucose; Glycogen; Insulin; Liver; Male; Phosphoenolpyruv | 1993 |
Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: effects of d-fenfluramine treatment.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Body Weight; Brain Chemistry; Catecholamines; Corticost | 1993 |
Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder.
Topics: Adult; Aging; Female; Fenfluramine; Humans; Hydrocortisone; Male; Menstrual Cycle; Middle Aged; Mult | 1995 |
Subchronic and chronic exposure to d-fenfluramine dose-dependently enhances splenic immune functions in young and old male Fischer-344 rats.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Fenfluramine; Killer Cells, Natural; Male; Rats; R | 1996 |
Responses to novelty stress in female F344 rats: effects of age and d-fenfluramine treatment.
Topics: Adrenocorticotropic Hormone; Age Factors; Aging; Animals; Behavior, Animal; Corticosterone; Female; | 1996 |
Chronic fenfluramine treatment of rats with different ages: effects on brain oxidative stress-related parameters.
Topics: Aging; Analysis of Variance; Animals; Appetite Depressants; Biotransformation; Brain; Catalase; Fenf | 1996 |
A longitudinal study of neurobiological mechanisms in boys with attention-deficit hyperactivity disorder: preliminary findings.
Topics: Aging; Attention Deficit Disorder with Hyperactivity; Blood Platelets; Brain; Catecholamines; Child; | 1999 |
Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding.
Topics: Aging; Animals; Biological Transport; Blood Glucose; Blotting, Northern; Body Weight; Deoxyglucose; | 1999 |
Effects of fenfluramine on body weight, feed intake, and reproductive activities of broiler breeder hens.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Weight; Chickens; Eating; Female; Fenfluramin | 1999 |
Prolactin response to d-fenfluramine in postmenopausal women on and off ERT: comparison with young women.
Topics: Adult; Affect; Aged; Aging; Cognition; Estrogen Replacement Therapy; Female; Fenfluramine; Humans; M | 2001 |
Fenfluramine and brain serotonin.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Dealkylation; Dihydroxyphenylalanine; | 1978 |
[Is fenfluramine a suitable therapeutic principle in obese aged diabetics?].
Topics: Adult; Aged; Aging; Animals; Anorexia; Diabetes Complications; Fenfluramine; Humans; Lactates; Male; | 1979 |
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem | 1992 |
Sustained decreases in weight and serum insulin, glucose, triacylglycerol and cholesterol in JCR:LA-corpulent rats treated with D-fenfluramine.
Topics: Adipose Tissue; Aging; Animals; Blood Glucose; Body Weight; Cholesterol; Corticosterone; Eating; Fat | 1992 |
Effects of subchronic d-fenfluramine on splenic immune functions in young and old male and female Fischer 344 rats.
Topics: Adjuvants, Immunologic; Aging; Animals; B-Lymphocytes; Female; Fenfluramine; Immune System; Killer C | 1991 |
Neuropathology & pathogenesis of experimental fenfluramine toxicity in young rodents.
Topics: Aging; Animals; Brain; Fenfluramine; Mice; Rats; Weight Gain | 1990 |
Postnatal application of p-chloroamphetamine or fenfluramine reduces response selection during early ontogenetic development of rat avoidance behaviour.
Topics: Aging; Amphetamines; Animals; Avoidance Learning; Escape Reaction; Extinction, Psychological; Fenflu | 1988 |