Page last updated: 2024-10-26

fenfluramine and Aging

fenfluramine has been researched along with Aging in 27 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Prolactin and cortisol responses to acute challenge with dl-fenfluramine (60 mg PO) were examined in 10 (6 women and 4 men) patients with seasonal affective disorder (SAD) and the same number of age, gender, menstrual status, and season matched healthy controls."7.69Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder. ( Michalon, M; Yatham, LN, 1995)
"It has been reported that benfluorex ameliorates the insulin resistance induced by high-fat feeding when its administration is initiated at the same time as the change in diet."3.70Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding. ( Gumà, A; Muñoz, P; Palacín, M; Sevilla, L; Testar, X; Zorzano, A, 1999)
"Prolactin and cortisol responses to acute challenge with dl-fenfluramine (60 mg PO) were examined in 10 (6 women and 4 men) patients with seasonal affective disorder (SAD) and the same number of age, gender, menstrual status, and season matched healthy controls."3.69Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder. ( Michalon, M; Yatham, LN, 1995)
"We determined the effects of D-fenfluramine treatment on the changes in vascular reactivity induced by aging."3.68Effect of aging and drug-induced weight reduction on rat vascular reactivity. ( Boulanger, M; Duhault, J; Feletou, M; Moreau, N, 1993)
" Treatment once a day for 14 days with 25 mg benfluorex per kg body weight lowered body weight, decreased circulating insulin and resulted in an increase in hepatic glycogen."3.68Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats. ( Geelen, MJ; Schmitz, MG; Tielens, AG; van den Heuvel, JM, 1993)
"To understand some of the mechanisms underlying the neuroendocrine and neurochemical changes associated with aging, we administered the serotonin [5-hydroxytryptamine (5-HT)] releaser and reuptake inhibitor d-fenfluramine (d-FEN; 0."3.68Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: effects of d-fenfluramine treatment. ( Burgess, LH; Cabrera, TM; Campbell, DB; Cross, MK; George, M; Gordon, BH; Handa, RJ; Hata, N; Lorens, SA, 1993)
"Benfluorex treatment lowered diastolic and systolic blood pressures and improved glucose tolerance in both age groups."2.68Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men. ( Beer, NA; Beer, RM; Colombo, C; Jakubowicz, DJ; Nestler, JE, 1995)
"Fenfluramine is an anorectic drug widely used for the regulation of food intake that presents some adverse effects at the central and peripheral levels."1.29Chronic fenfluramine treatment of rats with different ages: effects on brain oxidative stress-related parameters. ( Azzalis, LA; Camarini, R; Carlini, EA; D'Almeida, V; Junqueira, VB, 1996)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.81)18.7374
1990's18 (66.67)18.2507
2000's2 (7.41)29.6817
2010's2 (7.41)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Sun, Y1
Chebolu, S1
Skegrud, S1
Kamali, S1
Darmani, NA1
Whitney, KN1
Wenger, GR1
Burke, LK1
Doslikova, B1
D'Agostino, G1
Garfield, AS1
Farooq, G1
Burdakov, D1
Low, MJ1
Rubinstein, M1
Evans, ML1
Billups, B1
Heisler, LK1
Leshem, M1
Feletou, M1
Moreau, N1
Boulanger, M1
Duhault, J1
Nestler, JE1
Beer, NA1
Jakubowicz, DJ1
Colombo, C1
Beer, RM1
Panksepp, J1
Normansell, L1
Cox, JF1
Siviy, SM1
Tielens, AG1
van den Heuvel, JM1
Schmitz, MG1
Geelen, MJ1
Handa, RJ3
Cross, MK1
George, M2
Gordon, BH3
Burgess, LH1
Cabrera, TM1
Hata, N1
Campbell, DB3
Lorens, SA3
Yatham, LN1
Michalon, M1
Clancy, J2
Lorens, S1
D'Almeida, V1
Camarini, R1
Azzalis, LA1
Junqueira, VB1
Carlini, EA1
Halperin, JM2
Newcorn, JH2
Schwartz, ST2
Sharma, V1
Siever, LJ1
Koda, VH1
Gabriel, S1
Tanum, L1
Bråtveit-Johansen, K1
Malt, UF1
Pick, LH1
Sevilla, L1
Gumà, A1
Muñoz, P1
Testar, X1
Palacín, M1
Zorzano, A1
Rozenboim, I1
Kapkowska, E1
Robinzon, B1
Uni, Z1
Ramasubbu, R1
Flint, A1
Brown, G1
Awad, G1
Kennedy, S1
van Amelsvoort, TA1
Abel, KM1
Robertson, DM1
Daly, E1
Critchley, H1
Whitehead, M1
Murphy, DG1
Clineschmidt, BV1
Zacchei, AG1
Totaro, JA1
Pflueger, AB1
McGuffin, JC1
Wishousky, TI1
Förster, H1
Huth, K1
Koch, E1
Tunali, G1
Bell, J1
Zhang, XN1
Whitaker-Azmitia, PM1
Brindley, DN1
Hales, P1
al-Sieni, AI1
Russell, JC1
Petrovic, LM1
Thakkar, BK1
Dastur, DK1
Manghani, DK1
Köllner, O1
Köllner, U1
Göb, R1
Klingberg, F1

Trials

4 trials available for fenfluramine and Aging

ArticleYear
Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men.
    The Journal of clinical endocrinology and metabolism, 1995, Volume: 80, Issue:2

    Topics: Aged; Aging; Androgens; Blood Glucose; Blood Pressure; Dehydroepiandrosterone; Dehydroepiandrosteron

1995
Age-related changes in the association between serotonergic function and aggression in boys with ADHD.
    Biological psychiatry, 1997, Mar-15, Volume: 41, Issue:6

    Topics: Aggression; Aging; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male;

1997
Fenfluramine and idiopathic pain: a serotonergic study in non-psychiatric patients with functional gastrointestinal disorder.
    Scandinavian journal of gastroenterology, 1998, Volume: 33, Issue:7

    Topics: Adult; Aging; Analysis of Variance; Chronic Disease; Female; Fenfluramine; Gastrointestinal Diseases

1998
Neurohormonal responses to D-fenfluramine in healthy elderly subjects. A placebo-controlled study.
    Psychoneuroendocrinology, 2000, Volume: 25, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Behavior; Body Weight; Female; Fenfluramine; Hemodynamics; Humans; H

2000

Other Studies

23 other studies available for fenfluramine and Aging

ArticleYear
Effects of low-doses of methamphetamine on d-fenfluramine-induced head-twitch response (HTR) in mice during ageing and c-fos expression in the prefrontal cortex.
    BMC neuroscience, 2023, 01-11, Volume: 24, Issue:1

    Topics: Adrenergic Agents; Aging; Animals; Fenfluramine; Humans; Methamphetamine; Mice; Prefrontal Cortex; P

2023
Impulsivity and motor activity in aged, male Ts65Dn mice.
    Experimental and clinical psychopharmacology, 2013, Volume: 21, Issue:5

    Topics: Aging; Animals; Central Nervous System Stimulants; Conditioning, Operant; Dextroamphetamine; Disease

2013
5-HT obesity medication efficacy via POMC activation is maintained during aging.
    Endocrinology, 2014, Volume: 155, Issue:10

    Topics: Aging; Animals; Female; Fenfluramine; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesit

2014
Ontogeny of fenfluramine and amphetamine anorexia compared in rat pups.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:6

    Topics: Aging; Amphetamine; Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Fenfluramine; Mu

1981
Effect of aging and drug-induced weight reduction on rat vascular reactivity.
    Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:1

    Topics: Administration, Oral; Aging; Animals; Aorta; Blood Glucose; Body Weight; Endothelium, Vascular; Fenf

1993
Effects of neonatal decortication on the social play of juvenile rats.
    Physiology & behavior, 1994, Volume: 56, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Appetitive Behavior; Brain Mapping; Cerebral Cortex; Cerebral Deco

1994
Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats.
    Biochemical pharmacology, 1993, Nov-02, Volume: 46, Issue:9

    Topics: Aging; Animals; Body Weight; Fenfluramine; Glucose; Glycogen; Insulin; Liver; Male; Phosphoenolpyruv

1993
Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: effects of d-fenfluramine treatment.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:1

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Body Weight; Brain Chemistry; Catecholamines; Corticost

1993
Hormonal responses to dl-fenfluramine challenge are not blunted in seasonal affective disorder.
    Psychoneuroendocrinology, 1995, Volume: 20, Issue:4

    Topics: Adult; Aging; Female; Fenfluramine; Humans; Hydrocortisone; Male; Menstrual Cycle; Middle Aged; Mult

1995
Subchronic and chronic exposure to d-fenfluramine dose-dependently enhances splenic immune functions in young and old male Fischer-344 rats.
    Behavioural brain research, 1996, Volume: 73, Issue:1-2

    Topics: Aging; Animals; Dose-Response Relationship, Drug; Fenfluramine; Killer Cells, Natural; Male; Rats; R

1996
Responses to novelty stress in female F344 rats: effects of age and d-fenfluramine treatment.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 53, Issue:3

    Topics: Adrenocorticotropic Hormone; Age Factors; Aging; Animals; Behavior, Animal; Corticosterone; Female;

1996
Chronic fenfluramine treatment of rats with different ages: effects on brain oxidative stress-related parameters.
    Journal of biochemical toxicology, 1996, Volume: 11, Issue:4

    Topics: Aging; Analysis of Variance; Animals; Appetite Depressants; Biotransformation; Brain; Catalase; Fenf

1996
A longitudinal study of neurobiological mechanisms in boys with attention-deficit hyperactivity disorder: preliminary findings.
    Biological psychiatry, 1999, Feb-01, Volume: 45, Issue:3

    Topics: Aging; Attention Deficit Disorder with Hyperactivity; Blood Platelets; Brain; Catecholamines; Child;

1999
Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding.
    Life sciences, 1999, Volume: 64, Issue:1

    Topics: Aging; Animals; Biological Transport; Blood Glucose; Blotting, Northern; Body Weight; Deoxyglucose;

1999
Effects of fenfluramine on body weight, feed intake, and reproductive activities of broiler breeder hens.
    Poultry science, 1999, Volume: 78, Issue:12

    Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Weight; Chickens; Eating; Female; Fenfluramin

1999
Prolactin response to d-fenfluramine in postmenopausal women on and off ERT: comparison with young women.
    Psychoneuroendocrinology, 2001, Volume: 26, Issue:5

    Topics: Adult; Affect; Aged; Aging; Cognition; Estrogen Replacement Therapy; Female; Fenfluramine; Humans; M

2001
Fenfluramine and brain serotonin.
    Annals of the New York Academy of Sciences, 1978, Jun-12, Volume: 305

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Dealkylation; Dihydroxyphenylalanine;

1978
[Is fenfluramine a suitable therapeutic principle in obese aged diabetics?].
    Fortschritte der Medizin, 1979, Jan-25, Volume: 97, Issue:4

    Topics: Adult; Aged; Aging; Animals; Anorexia; Diabetes Complications; Fenfluramine; Humans; Lactates; Male;

1979
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
    Brain research, 1992, Feb-07, Volume: 571, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem

1992
Sustained decreases in weight and serum insulin, glucose, triacylglycerol and cholesterol in JCR:LA-corpulent rats treated with D-fenfluramine.
    British journal of pharmacology, 1992, Volume: 105, Issue:3

    Topics: Adipose Tissue; Aging; Animals; Blood Glucose; Body Weight; Cholesterol; Corticosterone; Eating; Fat

1992
Effects of subchronic d-fenfluramine on splenic immune functions in young and old male and female Fischer 344 rats.
    International journal of immunopharmacology, 1991, Volume: 13, Issue:8

    Topics: Adjuvants, Immunologic; Aging; Animals; B-Lymphocytes; Female; Fenfluramine; Immune System; Killer C

1991
Neuropathology & pathogenesis of experimental fenfluramine toxicity in young rodents.
    The Indian journal of medical research, 1990, Volume: 92

    Topics: Aging; Animals; Brain; Fenfluramine; Mice; Rats; Weight Gain

1990
Postnatal application of p-chloroamphetamine or fenfluramine reduces response selection during early ontogenetic development of rat avoidance behaviour.
    Biomedica biochimica acta, 1988, Volume: 47, Issue:12

    Topics: Aging; Amphetamines; Animals; Avoidance Learning; Escape Reaction; Extinction, Psychological; Fenflu

1988