fenfluramine has been researched along with Aggression in 74 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of serotonin in aggression and impulsivity was examined by administering the serotonin-releasing drug, d, l-fenfluramine and measuring effects on aggressive and impulsive responding under controlled laboratory conditions." | 9.09 | Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. ( Cherek, DR; Lane, SD, 1999) |
| "The role of serotonin in human aggression was evaluated by administering D-fenfluramine and comparing the effects on laboratory measures of aggression, escape and impulsivity among subjects with and without a history of conduct disorder." | 9.09 | Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder. ( Cherek, DR; Lane, SD, 2001) |
| "Hormonal responses to challenge with the 5-HT2A/2C probe d-fenfluramine and hormonal and thermal responses to challenge with the 5-HT1A probe ipsapirone were correlated with self-report and historical assessments of aggression in a pilot sample of eight male personality-disordered individuals." | 7.69 | Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. ( Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1995) |
| "Prolactin (PRL) responses to acute challenge with the serotonin (5-HT) releaser/uptake inhibitor, d-fenfluramine (PRL[d-FEN]), were correlated with three different measures of aggression in 14 male personality-disordered subjects." | 7.69 | Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men. ( Berman, ME; Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1996) |
| "This study compared the nature and magnitude of the relationship between aggression and CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration with that between aggression and the prolactin response to d-fenfluramine challenge in human subjects." | 7.69 | Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. ( Coccaro, EF; Cooper, TB; Hauger, RL; Kavoussi, RJ, 1997) |
| "Fenfluramine or norfenfluramine produced a marked and persistent depletion of whole-brain serotonin and antagonized potently the apomorphine-induced aggression response in Long Evans male rats." | 7.66 | Dissociation of the antiaggression and serotonin-depleting effects of fenfluramine. ( McKenzie, GM, 1981) |
| "Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder." | 5.32 | Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. ( Kelly, TM; Malone, KM; Mann, JJ; Soloff, PH; Strotmeyer, SJ, 2003) |
| "To determine whether normative variability in aggressive behavior correlates negatively with central nervous system (CNS) serotonergic function among men, plasma prolactin (PRL) responses to a standard fenfluramine challenge (administered to assess central serotonergic responsivity) were examined in relation to interview-assessed aggression histories among 118 adult males derived from a nonpatient, community sample." | 5.10 | Central nervous system serotonergic responsivity and aggressive disposition in men. ( Ferrell, RE; Flory, JD; Manuck, SB; Muldoon, MF, 2002) |
| "The role of serotonin in aggression and impulsivity was examined by administering the serotonin-releasing drug, d, l-fenfluramine and measuring effects on aggressive and impulsive responding under controlled laboratory conditions." | 5.09 | Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. ( Cherek, DR; Lane, SD, 1999) |
| "The role of serotonin in human aggression was evaluated by administering D-fenfluramine and comparing the effects on laboratory measures of aggression, escape and impulsivity among subjects with and without a history of conduct disorder." | 5.09 | Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder. ( Cherek, DR; Lane, SD, 2001) |
| "Sixty male offenders with DSM-III-R personality disorders and 27 healthy staff controls were assessed using the Special Hospital Assessment of Personality and Socialisation (SHAPS), impulsivity and aggression ratings, d-fenfluramine challenge and plasma hormone concentrations." | 3.71 | Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders. ( Anderson, IM; Deakin, JF; Dolan, M, 2001) |
| "To assess the relationship between two phenotypes in an extremely well-characterized population of personality disorder patients-impulsive aggression and prolactin response to fenfluramine-and tryptophan hydroxylase (TPH) genotype, TPH genotype (at an intronic polymorphic site) and prolactin response to fenfluramine were assessed in 40 Caucasian patients with personality disorder." | 3.70 | Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. ( Gelernter, J; Mitropoulou, V; New, AS; Nielsen, DA; Siever, LJ; Silverman, J; Trestman, RL; Yovell, Y, 1998) |
| "The CSF AVP level was correlated directly with life history of general aggression and aggression against persons and inversely with PRL[d-FEN] responses (but not with CSF 5-hydroxyindoleacetic acid), which in turn was correlated inversely with these 2 measures of life history of aggression." | 3.70 | Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects. ( Coccaro, EF; Cooper, TB; Ferris, CF; Hauger, RL; Kavoussi, RJ, 1998) |
| "To test the hypothesis that traits of aggression and impulsivity correlate negatively with central serotonergic system function in a nonpatient population, a standard fenfluramine challenge (for assessment of serotonergic responsivity) and behavioral measurements germane to aggression/impulsivity were administered to a community-derived sample of 119 men and women." | 3.70 | Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. ( Flory, JD; Mann, JJ; Manuck, SB; Matthews, KA; McCaffery, JM; Muldoon, MF, 1998) |
| " All subjects were administered standard interview and questionnaire indices of aggression and anger-related traits of personality; in a portion of subjects, CNS serotonergic activity was assessed by neuropsychopharmacologic challenge (prolactin response to fenfluramine hydrochloride)." | 3.70 | Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. ( Dent, KM; Ferrell, RE; Flory, JD; Mann, JJ; Manuck, SB; Muldoon, MF, 1999) |
| "Body temperature change in response to the serotonergic (5-HT) enhancer, d,l-fenfluramine (FEN), was examined in 27 prepubescent boys diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) to determine (1) the utility of this measure as an index of central serotonergic function; and (2) if the magnitude of temperature change is associated with aggression." | 3.70 | Thermal response to serotonergic challenge and aggression in attention deficit hyperactivity disorder children. ( Donovan, AM; Halperin, JM; Newcorn, JH; Sharma, V, 1999) |
| "Hormonal responses to challenge with the 5-HT2A/2C probe d-fenfluramine and hormonal and thermal responses to challenge with the 5-HT1A probe ipsapirone were correlated with self-report and historical assessments of aggression in a pilot sample of eight male personality-disordered individuals." | 3.69 | Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. ( Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1995) |
| "Prolactin (PRL) responses to acute challenge with the serotonin (5-HT) releaser/uptake inhibitor, d-fenfluramine (PRL[d-FEN]), were correlated with three different measures of aggression in 14 male personality-disordered subjects." | 3.69 | Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men. ( Berman, ME; Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1996) |
| " This study examines the prolactin response to fenfluramine hydrochloride challenge in young boys who show clinically significant aggressive behavior or who are raised in a social environment that is conducive to the development of chronic aggression." | 3.69 | Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing. ( Cooper, TB; Coplan, JD; Davies, M; Fried, JE; Greenhill, L; Miller, LS; Parsons, B; Pine, DS; Shaffer, D; Wasserman, GA, 1997) |
| "This study compared the nature and magnitude of the relationship between aggression and CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration with that between aggression and the prolactin response to d-fenfluramine challenge in human subjects." | 3.69 | Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. ( Coccaro, EF; Cooper, TB; Hauger, RL; Kavoussi, RJ, 1997) |
| "Fenfluramine or norfenfluramine produced a marked and persistent depletion of whole-brain serotonin and antagonized potently the apomorphine-induced aggression response in Long Evans male rats." | 3.66 | Dissociation of the antiaggression and serotonin-depleting effects of fenfluramine. ( McKenzie, GM, 1981) |
| "Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder." | 1.32 | Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. ( Kelly, TM; Malone, KM; Mann, JJ; Soloff, PH; Strotmeyer, SJ, 2003) |
| " Fifteen MDMA users, who did not have other drug dependencies or alcohol abuse, and had not used other drugs for prolonged periods, and 15 control individuals were included in a study to assess the biological and psychological changes after chronic use of MDMA." | 1.30 | Serotonergic function after (+/-)3,4-methylene-dioxymethamphetamine ('Ecstasy') in humans. ( Caccavari, R; Delsignore, R; Gerra, G; Giucastro, G; Maestri, D; Monica, C; Sartori, R; Zaimovic, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (16.22) | 18.7374 |
| 1990's | 37 (50.00) | 18.2507 |
| 2000's | 22 (29.73) | 29.6817 |
| 2010's | 3 (4.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bethea, CL | 1 |
| Reddy, AP | 1 |
| Robertson, N | 1 |
| Coleman, K | 1 |
| Kumar, AM | 1 |
| Kumar, M | 1 |
| Lahey, BB | 1 |
| Katz, DA | 1 |
| Fernandez, B | 1 |
| Shaw, JA | 1 |
| Campo, A | 1 |
| Nemeroff, CB | 1 |
| Sher, L | 1 |
| Stanley, BH | 1 |
| Cooper, TB | 7 |
| Malone, KM | 3 |
| Mann, JJ | 8 |
| Oquendo, MA | 3 |
| Coccaro, EF | 12 |
| Lee, R | 1 |
| Kavoussi, RJ | 7 |
| Lanctôt, KL | 1 |
| Herrmann, N | 1 |
| Eryavec, G | 1 |
| van Reekum, R | 1 |
| Reed, K | 1 |
| Naranjo, CA | 1 |
| Manuck, SB | 6 |
| Flory, JD | 4 |
| Muldoon, MF | 4 |
| Ferrell, RE | 2 |
| Soloff, PH | 2 |
| Kelly, TM | 1 |
| Strotmeyer, SJ | 1 |
| Halperin, JM | 8 |
| Schulz, KP | 4 |
| McKay, KE | 1 |
| Sharma, V | 5 |
| Newcorn, JH | 8 |
| Birger, M | 1 |
| Swartz, M | 1 |
| Cohen, D | 1 |
| Alesh, Y | 1 |
| Grishpan, C | 1 |
| Kotelr, M | 1 |
| van der Vegt, BJ | 1 |
| Lieuwes, N | 1 |
| Cremers, TI | 1 |
| de Boer, SF | 1 |
| Koolhaas, JM | 1 |
| Tiefenbacher, S | 1 |
| Davenport, MD | 1 |
| Novak, MA | 1 |
| Pouliot, AL | 1 |
| Meyer, JS | 1 |
| Krunic, A | 1 |
| Parsey, RV | 1 |
| Milak, M | 1 |
| Anderson, A | 1 |
| van Heertum, RL | 1 |
| John Mann, J | 1 |
| Berglund, K | 1 |
| Fahlke, C | 1 |
| Berggren, U | 1 |
| Eriksson, M | 1 |
| Balldin, J | 1 |
| Kalmar, JH | 1 |
| Marks, DJ | 2 |
| Miller, SR | 1 |
| Miller, C | 1 |
| Harty, S | 1 |
| Weischer, ML | 2 |
| Petkov, VV | 1 |
| McKenzie, GM | 1 |
| Wagner, GC | 1 |
| Fisher, H | 1 |
| Pole, N | 1 |
| Borve, T | 1 |
| Johnson, SK | 1 |
| Kyes, RC | 1 |
| Botchin, MB | 2 |
| Kaplan, JR | 3 |
| Silverman, JM | 1 |
| Klar, HM | 2 |
| Horvath, TB | 1 |
| Siever, LJ | 8 |
| Schwartz, ST | 2 |
| Matier, K | 1 |
| Wornell, G | 1 |
| Gerra, G | 4 |
| Fertonani, G | 2 |
| Tagliavini, P | 1 |
| Zaimovic, A | 4 |
| Delsignore, R | 4 |
| Maestri, D | 3 |
| Avanzini, P | 2 |
| Caccavari, R | 4 |
| Brambilla, F | 2 |
| Herpertz, S | 1 |
| Steinmeyer, SM | 1 |
| Marx, D | 1 |
| Oidtmann, A | 1 |
| Sass, H | 1 |
| Hauger, RL | 5 |
| Berman, ME | 1 |
| Rota-Graziosi, I | 1 |
| Lucchini, A | 1 |
| Koda, VH | 1 |
| Gabriel, S | 2 |
| Cleare, AJ | 1 |
| Bond, AJ | 1 |
| Palladino, M | 1 |
| Chittolini, B | 1 |
| Giucastro, G | 2 |
| Monica, C | 2 |
| Fertonani-Affini, G | 1 |
| Pine, DS | 1 |
| Coplan, JD | 1 |
| Wasserman, GA | 1 |
| Miller, LS | 1 |
| Fried, JE | 1 |
| Davies, M | 1 |
| Greenhill, L | 1 |
| Shaffer, D | 1 |
| Parsons, B | 1 |
| Trestman, RL | 3 |
| Gabriel, SM | 1 |
| New, AS | 2 |
| Gelernter, J | 1 |
| Yovell, Y | 1 |
| Nielsen, DA | 1 |
| Silverman, J | 1 |
| Mitropoulou, V | 2 |
| Wadman, M | 2 |
| Ferris, CF | 1 |
| McCaffery, JM | 1 |
| Matthews, KA | 1 |
| Sartori, R | 1 |
| Netter, P | 1 |
| Hennig, J | 1 |
| Rohrmann, S | 1 |
| Dent, KM | 1 |
| Buchsbaum, MS | 1 |
| Spiegel-Cohen, J | 1 |
| Wei, T | 1 |
| Hazlett, EA | 1 |
| Sevin, E | 1 |
| Nunn, M | 1 |
| Donovan, AM | 1 |
| Cherek, DR | 2 |
| Lane, SD | 2 |
| Fava, M | 1 |
| Vuolo, RD | 1 |
| Wright, EC | 1 |
| Nierenberg, AA | 1 |
| Alpert, JE | 1 |
| Rosenbaum, JF | 1 |
| Evans, J | 1 |
| Platts, H | 1 |
| Lightman, S | 1 |
| Nutt, D | 1 |
| Lynch, KG | 1 |
| Moss, HB | 1 |
| Dolan, M | 2 |
| Anderson, IM | 1 |
| Deakin, JF | 1 |
| Reist, C | 1 |
| Mazzanti, C | 1 |
| Vu, R | 1 |
| Tran, D | 1 |
| Goldman, D | 1 |
| Hilts, PJ | 1 |
| Kamali, M | 1 |
| Deakin, WJ | 1 |
| Roberts, N | 1 |
| Anderson, I | 1 |
| Schmeidler, J | 1 |
| Tu, JB | 1 |
| Hartridge, C | 1 |
| Izawa, J | 1 |
| Stoff, DM | 1 |
| Pasatiempo, AP | 1 |
| Yeung, J | 1 |
| Bridger, WH | 1 |
| Rabinovich, H | 1 |
| Raleigh, MJ | 2 |
| McGuire, MT | 2 |
| Brammer, GL | 2 |
| Pollack, DB | 1 |
| Yuwiler, A | 2 |
| Harvey, PD | 1 |
| Kupsaw-Lawrence, E | 1 |
| Herbert, JL | 1 |
| Bernstein, DP | 1 |
| Ritvo, ER | 1 |
| Geller, E | 1 |
| Fishbein, DH | 1 |
| Lozovsky, D | 1 |
| Jaffe, JH | 1 |
| Maurer, G | 1 |
| Cochrane, K | 1 |
| Mohs, RC | 1 |
| Davis, KL | 1 |
| File, SE | 1 |
| Guardiola-Lemaitre, BJ | 1 |
| Yarbrough, E | 1 |
| Santat, U | 1 |
| Perel, I | 1 |
| Webster, C | 1 |
| Lombardi, R | 1 |
| Campbell, M | 1 |
| Perry, R | 1 |
| Polonsky, BB | 1 |
| Deutsch, SI | 1 |
| Palij, M | 1 |
| Lukashok, D | 1 |
| Valzelli, L | 1 |
| Pankesepp, J | 1 |
| Zolovick, AJ | 1 |
| Jalowiec, JE | 1 |
| Stern, WC | 1 |
| Morgane, PJ | 1 |
| Opitz, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513] | Phase 2 | 35 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fenfluramine and Aggression
| Article | Year |
|---|---|
Aggression: the testosterone-serotonin link.
Topics: Aggression; Animals; Female; Fenfluramine; Humans; Hydroxyindoleacetic Acid; Macaca mulatta; Male; P | 2003 |
Understanding the neurobiology of suicidal behavior.
Topics: Adolescent; Adult; Aggression; Atrophy; Brain; Cholesterol; Fenfluramine; Humans; Norepinephrine; Pr | 2001 |
Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship.
Topics: Affective Disorders, Psychotic; Aggression; Brain Chemistry; Fenfluramine; Humans; Impulsive Behavio | 1992 |
18 trials available for fenfluramine and Aggression
| Article | Year |
|---|---|
Effects of aromatase inhibition and androgen activity on serotonin and behavior in male macaques.
Topics: 5-alpha Reductase Inhibitors; Aggression; Analysis of Variance; Androgens; Animals; Aromatase; Aroma | 2013 |
Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls.
Topics: Adult; Aggression; Alcohol-Related Disorders; Depression; Emergency Services, Psychiatric; Female; F | 2008 |
Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects.
Topics: Adult; Aggression; Analysis of Variance; Disruptive, Impulse Control, and Conduct Disorders; Female; | 2010 |
Central nervous system serotonergic responsivity and aggressive disposition in men.
Topics: Adult; Aggression; Central Nervous System; Fenfluramine; Genotype; Humans; Male; Middle Aged; Monoam | 2002 |
Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder.
Topics: Adult; Aggression; Borderline Personality Disorder; Brain Chemistry; Cerebral Cortex; Depressive Dis | 2005 |
The significance of aggression and impulsivity for self-mutilative behavior.
Topics: Adult; Aggression; Biomarkers; Depression; Disruptive, Impulse Control, and Conduct Disorders; Femal | 1995 |
Hostility in heroin abusers subtypes: fluoxetine and naltrexone treatment.
Topics: Adult; Aggression; Antidepressive Agents, Second-Generation; Fenfluramine; Fluoxetine; Heroin Depend | 1995 |
Age-related changes in the association between serotonergic function and aggression in boys with ADHD.
Topics: Aggression; Aging; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; | 1997 |
Serotonin function and antiaggressive response to fluoxetine: a pilot study.
Topics: Adolescent; Adolescent Behavior; Adult; Aggression; Double-Blind Method; Fenfluramine; Fluoxetine; H | 1997 |
Psychobiological differences between the aggression and psychoticism dimension.
Topics: Adult; Aggression; Compulsive Personality Disorder; Cross-Over Studies; Double-Blind Method; Emotion | 1999 |
d,l-fenfluramine response in impulsive personality disorder assessed with [18F]fluorodeoxyglucose positron emission tomography.
Topics: Adult; Aggression; Brain Chemistry; Brain Mapping; Female; Fenfluramine; Fluorodeoxyglucose F18; Hum | 1999 |
Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder.
Topics: Adult; Aggression; Conduct Disorder; Fenfluramine; Humans; Impulsive Behavior; Male; Reinforcement, | 1999 |
Impulsiveness and the prolactin response to d-fenfluramine.
Topics: Adult; Aggression; Fenfluramine; Humans; Impulsive Behavior; Male; Personality; Prolactin; Serotonin | 2000 |
Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine.
Topics: Adult; Aggression; Alleles; Analysis of Variance; Carrier Proteins; DNA; Fenfluramine; Gene Frequenc | 2001 |
Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder.
Topics: Adult; Aggression; Conduct Disorder; Disruptive, Impulse Control, and Conduct Disorders; Electrocard | 2001 |
Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents.
Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorde | 1992 |
Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers.
Topics: Adult; Aggression; Fenfluramine; Humans; Hydrocortisone; Impulsive Behavior; Male; Prolactin; Psycho | 1989 |
Effects of fenfluramine on autistic individuals residing in a state developmental center.
Topics: Adolescent; Adult; Aggression; Autistic Disorder; Child; Clinical Trials as Topic; Double-Blind Meth | 1987 |
53 other studies available for fenfluramine and Aggression
| Article | Year |
|---|---|
Marked reduction in serotonergic activity in a sexually aggressive adolescent male.
Topics: Adolescent; Aggression; Analysis of Variance; Carbon Isotopes; Fenfluramine; Humans; Male; Prolactin | 2014 |
Central serotonergic activity is related to the aggressive behaviors of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Brain; Depressive Disorder; Down-Regulation; | 2002 |
Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder.
Topics: Adult; Aggression; Body Mass Index; Borderline Personality Disorder; Diagnostic and Statistical Manu | 2003 |
Familial correlates of central serotonin function in children with disruptive behavior disorders.
Topics: Aggression; Attention Deficit and Disruptive Behavior Disorders; Child; Child Behavior Disorders; Fe | 2003 |
Cerebrospinal fluid monoamine and metabolite concentrations and aggression in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5,7-Dihydroxytryptamine; Aggression; Animals; Biogenic Monoamines; C | 2003 |
Fenfluramine challenge, self-injurious behavior, and aggression in rhesus monkeys.
Topics: Aggression; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Fenfluramine; Hydrocortison | 2003 |
Personality profile in type I alcoholism: long duration of alcohol intake and low serotonergic activity are predictive factors of anxiety proneness.
Topics: Adult; Aged; Aggression; Alcoholism; Anxiety; Fenfluramine; Humans; Male; Middle Aged; Personality; | 2006 |
Elevated childhood serotonergic function protects against adolescent aggression in disruptive boys.
Topics: Adolescent; Adolescent Behavior; Adult; Aggression; Child; Child, Preschool; Conduct Disorder; Fenfl | 2006 |
The interaction of psychosocial adversity and biological risk in childhood aggression.
Topics: Aggression; Antisocial Personality Disorder; Attention Deficit and Disruptive Behavior Disorders; Ch | 2007 |
Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder.
Topics: Adolescent; Adult; Aggression; Antisocial Personality Disorder; Area Under Curve; Attention Deficit | 2007 |
[Influence of anorectics of the amphetamine series on the behavior of the Siamese warrior fish Betta splendens].
Topics: Aggression; Animals; Appetite Depressants; Behavior, Animal; Chlorphentermine; Dextroamphetamine; Fe | 1966 |
Effect of nitrazepam and its combined administration with fenfluramine and cyproheptadine on explorative behaviour, muscle tone and coordination in normal mice and in mice with isolation syndrome.
Topics: Aggression; Animals; Cyproheptadine; Drug Interactions; Exploratory Behavior; Fenfluramine; Humans; | 1980 |
Dissociation of the antiaggression and serotonin-depleting effects of fenfluramine.
Topics: Aggression; Animals; Apomorphine; Brain Chemistry; Drug Interactions; Drug Tolerance; Fenfluramine; | 1981 |
Effects of monoaminergic agonists on alcohol-induced increases in mouse aggression.
Topics: Aggression; Animals; Behavior, Animal; Brain; Drug Synergism; Ethanol; Fenfluramine; Fluoxetine; Hyd | 1993 |
Aggression and brain serotonergic responsivity: response to slides in male macaques.
Topics: Aggression; Animals; Brain Chemistry; Fenfluramine; Macaca fascicularis; Male; Prolactin; Serotonin | 1995 |
Familial correlates of reduced central serotonergic system function in patients with personality disorders.
Topics: Aggression; Alcoholism; Family; Fenfluramine; Humans; Impulsive Behavior; Male; Personality Disorder | 1994 |
Low versus high prolactin responders to fenfluramine challenge: marker of behavioral differences in adult male cynomolgus macaques.
Topics: Aggression; Animals; Behavior, Animal; Fenfluramine; Macaca fascicularis; Male; Prolactin; Social Be | 1993 |
Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; Prolac | 1994 |
Serotonin function in detoxified heroin abusers: prolactin and cortisol responses to fenfluramine challenge.
Topics: Adult; Aggression; Antisocial Personality Disorder; Depressive Disorder; Fenfluramine; Heroin Depend | 1995 |
Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder.
Topics: Adult; Aggression; Behavior; Fenfluramine; Humans; Male; Personality Disorders; Pyrimidines; Seroton | 1995 |
Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men.
Topics: Adult; Aggression; Fenfluramine; Humans; Male; Middle Aged; Personality Disorders; Prolactin; Psychi | 1996 |
Does central serotonergic function correlate inversely with aggression? A study using D-fenfluramine in healthy subjects.
Topics: Adult; Aggression; Female; Fenfluramine; Humans; Hydrocortisone; Male; Prolactin; Selective Serotoni | 1997 |
Serotonergic function in mothers of opioid addicts: correlation with comorbid depression.
Topics: Adult; Aggression; Analysis of Variance; Antisocial Personality Disorder; Case-Control Studies; Code | 1997 |
Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing.
Topics: Aggression; Child; Child Abuse; Child Behavior Disorders; Child Rearing; Fenfluramine; Humans; Male; | 1997 |
Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects.
Topics: Adult; Aggression; Brain; Female; Fenfluramine; Humans; Hydroxyindoleacetic Acid; Male; Personality | 1997 |
Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness.
Topics: Adult; Aggression; Depression; Female; Fenfluramine; Humans; Male; Middle Aged; Personality Disorder | 1997 |
Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study.
Topics: Adult; Aggression; Female; Fenfluramine; Genotype; Humans; Impulsive Behavior; Male; Prolactin; Sele | 1998 |
Row erupts over child aggression study.
Topics: Aggression; Behavioral Research; Black or African American; Child; Clinical Protocols; Ethical Revie | 1998 |
US research safety system 'in jeopardy'.
Topics: Adult; Aggression; Bioethics; Child; Committee Membership; Ethical Review; Ethics Committees, Resear | 1998 |
Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects.
Topics: Adult; Aggression; Arginine Vasopressin; Female; Fenfluramine; Humans; Hydroxyindoleacetic Acid; Imp | 1998 |
Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample.
Topics: Adult; Affect; Aggression; Female; Fenfluramine; Humans; Impulsive Behavior; Male; Middle Aged; Sele | 1998 |
Serotonergic function after (+/-)3,4-methylene-dioxymethamphetamine ('Ecstasy') in humans.
Topics: Adolescent; Adult; Affect; Aggression; Exploratory Behavior; Fenfluramine; Hallucinogens; Humans; Hy | 1998 |
Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene.
Topics: Aggression; Alleles; Anger; Female; Fenfluramine; Genotype; Homozygote; Humans; Male; Personality Di | 1999 |
Thermal response to serotonergic challenge and aggression in attention deficit hyperactivity disorder children.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Body Temperature; Child; Fenfluramine; Hu | 1999 |
Fenfluramine challenge in unipolar depression with and without anger attacks.
Topics: Adult; Aggression; Analysis of Variance; Anger; Depressive Disorder, Major; Female; Fenfluramine; Hu | 2000 |
Serotonin, impulsivity, and alcohol use disorders in the older adolescent: a psychobiological study.
Topics: Adolescent; Adult; Aggression; Alcohol-Induced Disorders; Analysis of Variance; Chi-Square Distribut | 2000 |
Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders.
Topics: Adult; Aggression; Fenfluramine; Humans; Hydrocortisone; Impulsive Behavior; Male; Personality Disor | 2001 |
Inquiry clears ethics of child aggression study.
Topics: Adolescent; Aggression; Behavioral Research; Federal Government; Fenfluramine; Government; Governmen | 1999 |
Experiments on children are reviewed: research involved now-banned drug.
Topics: Advisory Committees; Aggression; Behavioral Research; Black or African American; Child; Federal Gove | 1998 |
Serotonergic and cognitive impairment in impulsive aggressive personality disordered offenders: are there implications for treatment?
Topics: Adult; Aggression; Analysis of Variance; Cluster Analysis; Fenfluramine; Humans; Hydrocortisone; Imp | 2002 |
Lack of seasonal rhythms in central serotonergic function in boys with ADHD.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; Period | 2002 |
Psychopharmacogenetic aspects of Prader-Willi syndrome.
Topics: Adolescent; Aggression; Appetite Depressants; Behavior Therapy; Carbamazepine; Combined Modality The | 1992 |
Use of serotonin-active agents in other psychiatric disorders.
Topics: Aggression; Fenfluramine; Humans; Impulsive Behavior; Male; Mental Disorders; Personality Disorders; | 1992 |
Effects of a low-fat diet on brain serotonergic responsivity in cynomolgus monkeys.
Topics: Aggression; Agonistic Behavior; Animals; Brain; Cholesterol; Dietary Fats; Fenfluramine; Macaca fasc | 1992 |
Serotonergic mechanisms promote dominance acquisition in adult male vervet monkeys.
Topics: Aggression; Animals; Behavior, Animal; Chlorocebus aethiops; Cyproheptadine; Fenfluramine; Fluoxetin | 1991 |
Development of neuropharmacologically based behavioral assessments of impulsive aggressive behavior.
Topics: Adult; Aggression; Anger; Depressive Disorder; Female; Fenfluramine; Humans; Hypothalamus; Impulsive | 1991 |
Effects of chronic fenfluramine on blood serotonin, cerebrospinal fluid metabolites, and behavior in monkeys.
Topics: Aggression; Animals; Behavior, Animal; Chlorocebus aethiops; Fenfluramine; Homovanillic Acid; Hydrox | 1986 |
Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior.
Topics: Adult; Aggression; Alcoholism; Depressive Disorder; Fenfluramine; Humans; Impulsive Behavior; Male; | 1989 |
l-fenfluramine in tests of dominance and anxiety in the rat.
Topics: Aggression; Animals; Anxiety; Competitive Behavior; Depression, Chemical; Exploratory Behavior; Fenf | 1988 |
An open study of fenfluramine in hospitalized young autistic children.
Topics: Aggression; Autistic Disorder; Child, Preschool; Female; Fenfluramine; Humans; Intelligence; Male; S | 1986 |
Further aspects of the exploratory behaviour in aggressive mice.
Topics: Aggression; Animals; Appetite Depressants; Behavior, Animal; Benzazepines; Exploratory Behavior; Fen | 1971 |
Fenfluramine: effects on aggression.
Topics: 5-Hydroxytryptophan; Aggression; Animals; Cats; Cortical Synchronization; Electric Stimulation; Elec | 1973 |
[Influence of fenfluramine, chlorphentermine, and related compounds on the behavior of aggressive mice].
Topics: Aggression; Animals; Appetite Depressants; Behavior, Animal; Chlordiazepoxide; Chlorphentermine; Cyp | 1972 |