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fenfluramine and Affective Disorders, Psychotic

fenfluramine has been researched along with Affective Disorders, Psychotic in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Affective Disorders, Psychotic: Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.

Research Excerpts

ExcerptRelevanceReference
" The apparently complex influence of weight loss on prolactin response to serotonergic challenge remains to be clarified as well as the role played by the bioavailability of the challenge drug and its metabolite."2.67Hormone responses to fenfluramine and placebo challenge in endogenous depression. ( Cooper, TB; Gillon, D; Kindler, S; Lerer, B; Lichtenberg, P; Newman, ME; Shapira, B, 1992)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mannel, M1
Müller-Oerlinghausen, B1
Czernik, A1
Sauer, H1
Lichtenberg, P1
Shapira, B1
Gillon, D1
Kindler, S1
Cooper, TB1
Newman, ME1
Lerer, B1
Coccaro, EF1

Reviews

1 review available for fenfluramine and Affective Disorders, Psychotic

ArticleYear
Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship.
    International clinical psychopharmacology, 1992,Spring, Volume: 7, Issue:1

    Topics: Affective Disorders, Psychotic; Aggression; Brain Chemistry; Fenfluramine; Humans; Impulsive Behavio

1992

Trials

2 trials available for fenfluramine and Affective Disorders, Psychotic

ArticleYear
5-HT brain function in affective disorder: d,l-fenfluramine-induced hormone release and clinical outcome in long-term lithium/carbamazepine prophylaxis.
    Journal of affective disorders, 1997, Volume: 46, Issue:2

    Topics: Adult; Affective Disorders, Psychotic; Carbamazepine; Depressive Disorder; Female; Fenfluramine; Hum

1997
Hormone responses to fenfluramine and placebo challenge in endogenous depression.
    Psychiatry research, 1992, Volume: 43, Issue:2

    Topics: Adult; Affective Disorders, Psychotic; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Met

1992