fenfluramine has been researched along with Affective Disorders, Psychotic in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Affective Disorders, Psychotic: Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The apparently complex influence of weight loss on prolactin response to serotonergic challenge remains to be clarified as well as the role played by the bioavailability of the challenge drug and its metabolite." | 2.67 | Hormone responses to fenfluramine and placebo challenge in endogenous depression. ( Cooper, TB; Gillon, D; Kindler, S; Lerer, B; Lichtenberg, P; Newman, ME; Shapira, B, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mannel, M | 1 |
| Müller-Oerlinghausen, B | 1 |
| Czernik, A | 1 |
| Sauer, H | 1 |
| Lichtenberg, P | 1 |
| Shapira, B | 1 |
| Gillon, D | 1 |
| Kindler, S | 1 |
| Cooper, TB | 1 |
| Newman, ME | 1 |
| Lerer, B | 1 |
| Coccaro, EF | 1 |
1 review available for fenfluramine and Affective Disorders, Psychotic
| Article | Year |
|---|---|
Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship.
Topics: Affective Disorders, Psychotic; Aggression; Brain Chemistry; Fenfluramine; Humans; Impulsive Behavio | 1992 |
2 trials available for fenfluramine and Affective Disorders, Psychotic
| Article | Year |
|---|---|
5-HT brain function in affective disorder: d,l-fenfluramine-induced hormone release and clinical outcome in long-term lithium/carbamazepine prophylaxis.
Topics: Adult; Affective Disorders, Psychotic; Carbamazepine; Depressive Disorder; Female; Fenfluramine; Hum | 1997 |
Hormone responses to fenfluramine and placebo challenge in endogenous depression.
Topics: Adult; Affective Disorders, Psychotic; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Met | 1992 |