fenfluramine has been researched along with Adverse Drug Event in 12 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Receptorome screening has implicated N-deethylation of fenfluramine and serotonin 5-hydroxy-t-ryptamine 2B receptors in the adverse effects of the drug; subsequent studies corroborated this finding." | 2.43 | Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'. ( Roth, BL; Setola, V, 2005) |
| "Benfluorex has been withdrawn from the French market in November 2009, after more than 30 years of use." | 1.37 | [Number of deaths attributable to benfluorex]. ( Hill, C, 2011) |
| " The main purpose of this study was to determine whether chronic administration of fenfluramine increases plasma 5-HT to concentrations that are associated with the development of valvular heart disease." | 1.35 | Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels. ( Baumann, MH; Rothman, RB; Zolkowska, D, 2008) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Droogmans, S | 1 |
| Kerkhove, D | 1 |
| Cosyns, B | 1 |
| Van Camp, G | 1 |
| Hajjo, R | 1 |
| Grulke, CM | 1 |
| Golbraikh, A | 1 |
| Setola, V | 2 |
| Huang, XP | 1 |
| Roth, BL | 2 |
| Tropsha, A | 1 |
| Hill, C | 1 |
| Menard, J | 1 |
| Butler, D | 1 |
| Benkimoun, P | 1 |
| Smith, DA | 1 |
| Schmid, EF | 1 |
| Zolkowska, D | 1 |
| Baumann, MH | 1 |
| Rothman, RB | 1 |
| Derby, LE | 1 |
| Myers, MW | 1 |
| Jick, H | 1 |
4 reviews available for fenfluramine and Adverse Drug Event
| Article | Year |
|---|---|
Role of echocardiography in toxic heart valvulopathy.
Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Echocardiography, Doppler, Color; Female; | 2009 |
Benfluorex: analysis of a drug-related public health crisis.
Topics: Attitude to Health; Communications Media; Drug Industry; Drug-Related Side Effects and Adverse React | 2011 |
Drug withdrawals and the lessons within.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbolines; Colitis, Ischemic; Drug Design; Drug-R | 2006 |
Screening the receptorome reveals molecular targets responsible for drug-induced side effects: focus on 'fen-phen'.
Topics: Animals; Appetite Depressants; Cardiovascular Diseases; Drug Evaluation, Preclinical; Drug-Related S | 2005 |
8 other studies available for fenfluramine and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Development, validation, and use of quantitative structure-activity relationship models of 5-hydroxytryptamine (2B) receptor ligands to identify novel receptor binders and putative valvulopathic compounds among common drugs.
Topics: Algorithms; Binding, Competitive; Databases, Factual; Dexfenfluramine; Drug-Related Side Effects and | 2010 |
[Number of deaths attributable to benfluorex].
Topics: Cause of Death; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; Humans; Hypolipidemic | 2011 |
France toughens conflict rules.
Topics: Conflict of Interest; Drug Approval; Drug Industry; Drug-Related Side Effects and Adverse Reactions; | 2011 |
Appetite suppressant was probably responsible for 1300 deaths, study shows.
Topics: Appetite Depressants; Drug Industry; Drug-Related Side Effects and Adverse Reactions; Fenfluramine; | 2012 |
In the wake of the Mediator scandal: some progress in France, but apathy at the European level.
Topics: Drug Approval; Drug Industry; Drug-Related Side Effects and Adverse Reactions; European Union; Fenfl | 2012 |
Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels.
Topics: Animals; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Fenfluramine | 2008 |
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke.
Topics: Aged; Appetite Depressants; Body Mass Index; Case-Control Studies; Cerebrovascular Disorders; Cohort | 1999 |