fenfluramine has been researched along with Acute Confusional Senile Dementia in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lanctôt, KL | 1 |
| Herrmann, N | 1 |
| Eryavec, G | 1 |
| van Reekum, R | 1 |
| Reed, K | 1 |
| Naranjo, CA | 1 |
| McLoughlin, DM | 1 |
| Lucey, JV | 1 |
| Dinan, TG | 1 |
| Mintzer, J | 1 |
| Brawman-Mintzer, O | 1 |
| Mirski, DF | 1 |
| Unger, R | 1 |
| Nietert, P | 1 |
| Meeks, A | 1 |
| Sampson, R | 1 |
| Cooper, JK | 1 |
| Mungas, D | 1 |
4 other studies available for fenfluramine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Central serotonergic activity is related to the aggressive behaviors of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Brain; Depressive Disorder; Down-Regulation; | 2002 |
Central serotonergic hyperresponsivity in late-onset Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Female; Fenfluramine; Geriatric Assessment; Humans; Male | 1994 |
Fenfluramine challenge test as a marker of serotonin activity in patients with Alzheimer's dementia and agitation.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Behavioral Symptoms; Biomarkers; Case-Control Studies; F | 1998 |
Serotonin response in sweet-food craving Alzheimer's disease subjects.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Feeding Behavior; Female; Fenfluramine; Humans; Male; Pr | 1992 |