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fenfluramine and Acromegaly

fenfluramine has been researched along with Acromegaly in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sulaiman, WR2
Johnson, RH2
Rennie, MJ1

Trials

1 trial available for fenfluramine and Acromegaly

ArticleYear
Hormonal and metabolic studies of the action of fenfluramine in normal man, obesity, acromegaly and diabetes mellitus.
    Postgraduate medical journal, 1975, Volume: 51 Suppl 1

    Topics: Acromegaly; Adult; Aged; Blood Glucose; Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Fenfl

1975

Other Studies

2 other studies available for fenfluramine and Acromegaly

ArticleYear
Editorial: Treatment of acromegaly.
    Lancet (London, England), 1974, Dec-21, Volume: 2, Issue:7895

    Topics: Acromegaly; Chlorpromazine; Cryosurgery; Evaluation Studies as Topic; Fenfluramine; Growth Hormone-R

1974
Effect of fenfluramine on human growth hormone release.
    British medical journal, 1973, May-12, Volume: 2, Issue:5862

    Topics: Acromegaly; Adult; Aged; Blood Glucose; Female; Fenfluramine; Growth Hormone; Humans; Injections, In

1973