fenfluramine has been researched along with Abortion, Spontaneous in 1 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Abortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Controlled prospective cohort study comparing 98 women who had taken phentermine/fenfluramine to 233 women who had not, all of whom contacted the California Teratogen Information Service during pregnancy." | 7.71 | Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine. ( Chambers, CD; Dick, LM; Felix, RJ; Johnson, KA; Jones, KL; Kao, KK, 2002) |
| "Controlled prospective cohort study comparing 98 women who had taken phentermine/fenfluramine to 233 women who had not, all of whom contacted the California Teratogen Information Service during pregnancy." | 3.71 | Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine. ( Chambers, CD; Dick, LM; Felix, RJ; Johnson, KA; Jones, KL; Kao, KK, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, KL | 1 |
| Johnson, KA | 1 |
| Dick, LM | 1 |
| Felix, RJ | 1 |
| Kao, KK | 1 |
| Chambers, CD | 1 |
1 other study available for fenfluramine and Abortion, Spontaneous
| Article | Year |
|---|---|
Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Appetite Depressants; Cohort Studies; Drug Thera | 2002 |