fenfluramine has been researched along with Abnormality, Heart in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lacroix, I | 1 |
| Hurault-Delarue, C | 1 |
| Montastruc, JL | 1 |
| Damase-Michel, C | 1 |
| Etienne, N | 1 |
| Schaerlinger, B | 1 |
| Jaffré, F | 1 |
| Maroteaux, L | 1 |
| Alexander, JH | 1 |
| Greenbaum, AB | 1 |
| Hudson, MP | 1 |
| Kong, DF | 1 |
| Miller, JM | 1 |
| Tung, CY | 1 |
| Whellan, DJ | 1 |
1 review available for fenfluramine and Abnormality, Heart
| Article | Year |
|---|---|
[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].
Topics: Adult; Animals; Cardiomyopathy, Dilated; Cell Survival; Fenfluramine; Fetal Heart; Genes, Lethal; Ge | 2004 |
2 other studies available for fenfluramine and Abnormality, Heart
| Article | Year |
|---|---|
Can benfluorex induce congenital malformations?
Topics: Animals; Appetite Depressants; Female; Fenfluramine; France; Heart Defects, Congenital; Humans; Mice | 2012 |
Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998.
Topics: Aged; Anti-Arrhythmia Agents; Anticholesteremic Agents; Appetite Depressants; Clinical Trials as Top | 1998 |