Page last updated: 2024-10-27

fenfluramine and Abnormality, Heart

fenfluramine has been researched along with Abnormality, Heart in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lacroix, I1
Hurault-Delarue, C1
Montastruc, JL1
Damase-Michel, C1
Etienne, N1
Schaerlinger, B1
Jaffré, F1
Maroteaux, L1
Alexander, JH1
Greenbaum, AB1
Hudson, MP1
Kong, DF1
Miller, JM1
Tung, CY1
Whellan, DJ1

Reviews

1 review available for fenfluramine and Abnormality, Heart

ArticleYear
[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].
    Journal de la Societe de biologie, 2004, Volume: 198, Issue:1

    Topics: Adult; Animals; Cardiomyopathy, Dilated; Cell Survival; Fenfluramine; Fetal Heart; Genes, Lethal; Ge

2004

Other Studies

2 other studies available for fenfluramine and Abnormality, Heart

ArticleYear
Can benfluorex induce congenital malformations?
    Diabetes & metabolism, 2012, Volume: 38, Issue:4

    Topics: Animals; Appetite Depressants; Female; Fenfluramine; France; Heart Defects, Congenital; Humans; Mice

2012
Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998.
    American heart journal, 1998, Volume: 136, Issue:1

    Topics: Aged; Anti-Arrhythmia Agents; Anticholesteremic Agents; Appetite Depressants; Clinical Trials as Top

1998