fenfluramine has been researched along with Abnormalities, Autosome in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") 2 h after Fen application, a strong synergism could be seen in the late treatment period as shown by the dose-response curves and by statistical analysis using the principle of least squares." | 1.29 | Potentiation by caffeine of the frequencies of chromosomal aberrations induced by chronic exposure to fenfluramine in mice. ( Agarwal, K; Mukherjee, A; Sen, S; Sharma, A, 1994) |
| " The degree of clastogenicity was directly proportional to the dosage used and inversely related with the duration of treatment." | 1.28 | Clastogenic effect of fenfluramine in mice bone marrow cells in vivo. ( Agarwal, K; Bhardwaj, KR; Mukherjee, A; Sen, S; Sharma, A; Sharma, R, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sen, S | 2 |
| Agarwal, K | 2 |
| Mukherjee, A | 2 |
| Sharma, A | 2 |
| Sharma, R | 1 |
| Bhardwaj, KR | 1 |
2 other studies available for fenfluramine and Abnormalities, Autosome
| Article | Year |
|---|---|
Potentiation by caffeine of the frequencies of chromosomal aberrations induced by chronic exposure to fenfluramine in mice.
Topics: Administration, Oral; Animals; Body Weight; Bone Marrow; Caffeine; Chromosome Aberrations; Dose-Resp | 1994 |
Clastogenic effect of fenfluramine in mice bone marrow cells in vivo.
Topics: Administration, Oral; Analysis of Variance; Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aber | 1992 |