Page last updated: 2024-10-27

fenfluramine and ADDH

fenfluramine has been researched along with ADDH in 21 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research Excerpts

ExcerptRelevanceReference
"A review of research studies published to date on the effects of fenfluramine on children with autism is presented."8.77Clinical effects of fenfluramine on children with autism: a review of the research. ( Banks, SR; du Verglas, G; Guyer, KE, 1988)
"Twenty boys (mean age, 9 +/- 2 years) with attention deficit disorder with hyperactivity received three weeks each of dextroamphetamine sulfate (0."5.06Fenfluramine and dextroamphetamine treatment of childhood hyperactivity. Clinical and biochemical findings. ( Donnelly, M; Keysor, CS; Murphy, DL; Oliver, J; Potter, WZ; Rapoport, JL, 1989)
"A review of research studies published to date on the effects of fenfluramine on children with autism is presented."4.77Clinical effects of fenfluramine on children with autism: a review of the research. ( Banks, SR; du Verglas, G; Guyer, KE, 1988)
"Body temperature change in response to the serotonergic (5-HT) enhancer, d,l-fenfluramine (FEN), was examined in 27 prepubescent boys diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) to determine (1) the utility of this measure as an index of central serotonergic function; and (2) if the magnitude of temperature change is associated with aggression."3.70Thermal response to serotonergic challenge and aggression in attention deficit hyperactivity disorder children. ( Donovan, AM; Halperin, JM; Newcorn, JH; Sharma, V, 1999)
"Parents of children with mental retardation or borderline IQ who took part in two drug studies were surveyed by mail 4 weeks after their involvement."2.68Consumer satisfaction with involvement in drug research: a social validity study. ( Aman, MG; Wolford, PL, 1995)
"Fenfluramine dosage was gradually increased to a standardized dose of 1."2.67Fenfluramine and methylphenidate in children with mental retardation and attention deficit hyperactivity disorder: laboratory effects. ( Aman, MG; Arnold, LE; Kern, RA; McGhee, DE, 1993)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19905 (23.81)18.7374
1990's13 (61.90)18.2507
2000's2 (9.52)29.6817
2010's1 (4.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ivanov, I1
Flory, J1
Newcorn, JH8
Halperin, JM8
Flory, JD1
Miller, C1
Harty, S1
Aman, MG6
Wolford, PL1
Kern, RA5
McGhee, DE3
Arnold, LE3
Sharma, V4
Siever, LJ2
Schwartz, ST3
Matier, K1
Wornell, G1
Koda, VH1
Gabriel, S2
Osborne, P1
Tumuluru, R1
Rojahn, J1
del Medico, V1
Schulz, KP2
McKay, KE1
Pick, LH1
Donovan, AM1
Schmeidler, J1
Stoff, DM2
Pasatiempo, AP2
Yeung, J1
Cooper, TB1
Bridger, WH2
Rabinovich, H2
Yeung, JH1
Sloman, L1
Donnelly, M3
Rapoport, JL3
Potter, WZ1
Oliver, J1
Keysor, CS1
Murphy, DL1
du Verglas, G1
Banks, SR1
Guyer, KE1
Ismond, DR1
Zametkin, A1
Ismond, D1

Reviews

4 reviews available for fenfluramine and ADDH

ArticleYear
Use of medication in pervasive developmental disorders.
    The Psychiatric clinics of North America, 1991, Volume: 14, Issue:1

    Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child

1991
Review of fenfluramine in the treatment of the developmental disabilities.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Clinical Trials as Topic; F

1989
Clinical effects of fenfluramine on children with autism: a review of the research.
    Journal of autism and developmental disorders, 1988, Volume: 18, Issue:2

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child, Preschoo

1988
New drug trials in attention deficit disorder.
    Psychopharmacology bulletin, 1985, Volume: 21, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Clorgyline; Desipram

1985

Trials

12 trials available for fenfluramine and ADDH

ArticleYear
Consumer satisfaction with involvement in drug research: a social validity study.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1995, Volume: 34, Issue:7

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Clinical Trials

1995
Fenfluramine and methylphenidate in children with mental retardation and attention deficit hyperactivity disorder: laboratory effects.
    Journal of autism and developmental disorders, 1993, Volume: 23, Issue:3

    Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cogni

1993
Fenfluramine and methylphenidate in children with mental retardation and ADHD: clinical and side effects.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1993, Volume: 32, Issue:4

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Double-Blind Met

1993
Age-related changes in the association between serotonergic function and aggression in boys with ADHD.
    Biological psychiatry, 1997, Mar-15, Volume: 41, Issue:6

    Topics: Aggression; Aging; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male;

1997
Fenfluramine and methylphenidate in children with mental retardation and borderline IQ: clinical effects.
    American journal of mental retardation : AJMR, 1997, Volume: 101, Issue:5

    Topics: Adolescent; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys

1997
Serotonin function and risk for alcoholism in boys with attention-deficit hyperactivity disorder.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1998, Volume: 18, Issue:1

    Topics: Alcoholism; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Hydrocortiso

1998
Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents.
    Psychiatry research, 1992, Volume: 43, Issue:3

    Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorde

1992
Fenfluramine and mental retardation.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1991, Volume: 30, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Double-Blind Method; Encopresis; Enuresis; Fenflurami

1991
Fenfluramine and dextroamphetamine treatment of childhood hyperactivity. Clinical and biochemical findings.
    Archives of general psychiatry, 1989, Volume: 46, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Blood Platelets; Child; Clinical Trials as Topic; Dex

1989
Review of fenfluramine in the treatment of the developmental disabilities.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1989, Volume: 28, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Clinical Trials as Topic; F

1989
Fenfluramine treatment of childhood attention deficit disorder with hyperactivity: a preliminary report.
    Psychopharmacology bulletin, 1986, Volume: 22, Issue:1

    Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Double-

1986
New drug trials in attention deficit disorder.
    Psychopharmacology bulletin, 1985, Volume: 21, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Clorgyline; Desipram

1985

Other Studies

7 other studies available for fenfluramine and ADDH

ArticleYear
Childhood serotonergic function and early adult outcomes in youth with ADHD: A 15-year follow-up study.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018, Volume: 28, Issue:12

    Topics: Adult; Antisocial Personality Disorder; Attention Deficit Disorder with Hyperactivity; Female; Fenfl

2018
Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder.
    The British journal of psychiatry : the journal of mental science, 2007, Volume: 190

    Topics: Adolescent; Adult; Aggression; Antisocial Personality Disorder; Area Under Curve; Attention Deficit

2007
Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder.
    The American journal of psychiatry, 1994, Volume: 151, Issue:2

    Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; Prolac

1994
A longitudinal study of neurobiological mechanisms in boys with attention-deficit hyperactivity disorder: preliminary findings.
    Biological psychiatry, 1999, Feb-01, Volume: 45, Issue:3

    Topics: Aging; Attention Deficit Disorder with Hyperactivity; Blood Platelets; Brain; Catecholamines; Child;

1999
Thermal response to serotonergic challenge and aggression in attention deficit hyperactivity disorder children.
    Journal of child and adolescent psychopharmacology, 1999, Volume: 9, Issue:2

    Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Body Temperature; Child; Fenfluramine; Hu

1999
Lack of seasonal rhythms in central serotonergic function in boys with ADHD.
    Psychoneuroendocrinology, 2002, Volume: 27, Issue:4

    Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; Period

2002
Test-retest reliability of the prolactin and cortisol responses to D,L-fenfluramine challenge in disruptive behavior disorders.
    Psychiatry research, 1992, Volume: 42, Issue:1

    Topics: Arousal; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Fenfluramin

1992