fenfluramine and ADDH
fenfluramine has been researched along with ADDH in 21 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "A review of research studies published to date on the effects of fenfluramine on children with autism is presented." | 8.77 | Clinical effects of fenfluramine on children with autism: a review of the research. ( Banks, SR; du Verglas, G; Guyer, KE, 1988) |
| "Twenty boys (mean age, 9 +/- 2 years) with attention deficit disorder with hyperactivity received three weeks each of dextroamphetamine sulfate (0." | 5.06 | Fenfluramine and dextroamphetamine treatment of childhood hyperactivity. Clinical and biochemical findings. ( Donnelly, M; Keysor, CS; Murphy, DL; Oliver, J; Potter, WZ; Rapoport, JL, 1989) |
| "A review of research studies published to date on the effects of fenfluramine on children with autism is presented." | 4.77 | Clinical effects of fenfluramine on children with autism: a review of the research. ( Banks, SR; du Verglas, G; Guyer, KE, 1988) |
| "Body temperature change in response to the serotonergic (5-HT) enhancer, d,l-fenfluramine (FEN), was examined in 27 prepubescent boys diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) to determine (1) the utility of this measure as an index of central serotonergic function; and (2) if the magnitude of temperature change is associated with aggression." | 3.70 | Thermal response to serotonergic challenge and aggression in attention deficit hyperactivity disorder children. ( Donovan, AM; Halperin, JM; Newcorn, JH; Sharma, V, 1999) |
| "Parents of children with mental retardation or borderline IQ who took part in two drug studies were surveyed by mail 4 weeks after their involvement." | 2.68 | Consumer satisfaction with involvement in drug research: a social validity study. ( Aman, MG; Wolford, PL, 1995) |
| "Fenfluramine dosage was gradually increased to a standardized dose of 1." | 2.67 | Fenfluramine and methylphenidate in children with mental retardation and attention deficit hyperactivity disorder: laboratory effects. ( Aman, MG; Arnold, LE; Kern, RA; McGhee, DE, 1993) |
Research
Studies (21)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (23.81) | 18.7374 |
| 1990's | 13 (61.90) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ivanov, I | 1 |
| Flory, J | 1 |
| Newcorn, JH | 8 |
| Halperin, JM | 8 |
| Flory, JD | 1 |
| Miller, C | 1 |
| Harty, S | 1 |
| Aman, MG | 6 |
| Wolford, PL | 1 |
| Kern, RA | 5 |
| McGhee, DE | 3 |
| Arnold, LE | 3 |
| Sharma, V | 4 |
| Siever, LJ | 2 |
| Schwartz, ST | 3 |
| Matier, K | 1 |
| Wornell, G | 1 |
| Koda, VH | 1 |
| Gabriel, S | 2 |
| Osborne, P | 1 |
| Tumuluru, R | 1 |
| Rojahn, J | 1 |
| del Medico, V | 1 |
| Schulz, KP | 2 |
| McKay, KE | 1 |
| Pick, LH | 1 |
| Donovan, AM | 1 |
| Schmeidler, J | 1 |
| Stoff, DM | 2 |
| Pasatiempo, AP | 2 |
| Yeung, J | 1 |
| Cooper, TB | 1 |
| Bridger, WH | 2 |
| Rabinovich, H | 2 |
| Yeung, JH | 1 |
| Sloman, L | 1 |
| Donnelly, M | 3 |
| Rapoport, JL | 3 |
| Potter, WZ | 1 |
| Oliver, J | 1 |
| Keysor, CS | 1 |
| Murphy, DL | 1 |
| du Verglas, G | 1 |
| Banks, SR | 1 |
| Guyer, KE | 1 |
| Ismond, DR | 1 |
| Zametkin, A | 1 |
| Ismond, D | 1 |
Reviews
4 reviews available for fenfluramine and ADDH
| Article | Year |
|---|---|
Use of medication in pervasive developmental disorders.
Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child | 1991 |
Review of fenfluramine in the treatment of the developmental disabilities.
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Clinical Trials as Topic; F | 1989 |
Clinical effects of fenfluramine on children with autism: a review of the research.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child, Preschoo | 1988 |
New drug trials in attention deficit disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Clorgyline; Desipram | 1985 |
Trials
12 trials available for fenfluramine and ADDH
| Article | Year |
|---|---|
Consumer satisfaction with involvement in drug research: a social validity study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Clinical Trials | 1995 |
Fenfluramine and methylphenidate in children with mental retardation and attention deficit hyperactivity disorder: laboratory effects.
Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cogni | 1993 |
Fenfluramine and methylphenidate in children with mental retardation and ADHD: clinical and side effects.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Double-Blind Met | 1993 |
Age-related changes in the association between serotonergic function and aggression in boys with ADHD.
Topics: Aggression; Aging; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; | 1997 |
Fenfluramine and methylphenidate in children with mental retardation and borderline IQ: clinical effects.
Topics: Adolescent; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys | 1997 |
Serotonin function and risk for alcoholism in boys with attention-deficit hyperactivity disorder.
Topics: Alcoholism; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Hydrocortiso | 1998 |
Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents.
Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorde | 1992 |
Fenfluramine and mental retardation.
Topics: Attention Deficit Disorder with Hyperactivity; Double-Blind Method; Encopresis; Enuresis; Fenflurami | 1991 |
Fenfluramine and dextroamphetamine treatment of childhood hyperactivity. Clinical and biochemical findings.
Topics: Attention Deficit Disorder with Hyperactivity; Blood Platelets; Child; Clinical Trials as Topic; Dex | 1989 |
Review of fenfluramine in the treatment of the developmental disabilities.
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Clinical Trials as Topic; F | 1989 |
Fenfluramine treatment of childhood attention deficit disorder with hyperactivity: a preliminary report.
Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Double- | 1986 |
New drug trials in attention deficit disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic; Clorgyline; Desipram | 1985 |
Other Studies
7 other studies available for fenfluramine and ADDH
| Article | Year |
|---|---|
Childhood serotonergic function and early adult outcomes in youth with ADHD: A 15-year follow-up study.
Topics: Adult; Antisocial Personality Disorder; Attention Deficit Disorder with Hyperactivity; Female; Fenfl | 2018 |
Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder.
Topics: Adolescent; Adult; Aggression; Antisocial Personality Disorder; Area Under Curve; Attention Deficit | 2007 |
Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; Prolac | 1994 |
A longitudinal study of neurobiological mechanisms in boys with attention-deficit hyperactivity disorder: preliminary findings.
Topics: Aging; Attention Deficit Disorder with Hyperactivity; Blood Platelets; Brain; Catecholamines; Child; | 1999 |
Thermal response to serotonergic challenge and aggression in attention deficit hyperactivity disorder children.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Body Temperature; Child; Fenfluramine; Hu | 1999 |
Lack of seasonal rhythms in central serotonergic function in boys with ADHD.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Child; Fenfluramine; Humans; Male; Period | 2002 |
Test-retest reliability of the prolactin and cortisol responses to D,L-fenfluramine challenge in disruptive behavior disorders.
Topics: Arousal; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Fenfluramin | 1992 |