fenclonine has been researched along with Vomiting in 6 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Loperamide, an opiate receptor agonist, commonly used in the treatment of diarrhoea, reliably induced emesis in the ferret, when given subcutaneously." | 7.68 | The neuropharmacology of loperamide-induced emesis in the ferret: the role of the area postrema, vagus, opiate and 5-HT3 receptors. ( Andrews, PL; Bhandari, P; Bingham, S, 1992) |
| "The involvement of 5-hydroxytryptamine (5-HT) with cisplatin-induced emesis in the ferret was investigated using reserpine, para-chlorophenylalanine and fenfluramine." | 7.67 | Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret. ( Barnes, JM; Barnes, NM; Costall, B; Naylor, RJ; Tattersall, FD, 1988) |
| " PCPA (2 g 8 hourly for 2 or 3 days prior to cisplatin) reduced the spontaneous urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), inhibited the increase in urinary 5-HIAA induced by cisplatin and markedly attenuated the acute period of nausea and vomiting associated with the cytotoxic drug." | 5.08 | Treatment with para-chlorophenylalanine antagonises the emetic response and the serotonin-releasing actions of cisplatin in cancer patients. ( Alfieri, AB; Cubeddu, LX, 1995) |
| "Loperamide, an opiate receptor agonist, commonly used in the treatment of diarrhoea, reliably induced emesis in the ferret, when given subcutaneously." | 3.68 | The neuropharmacology of loperamide-induced emesis in the ferret: the role of the area postrema, vagus, opiate and 5-HT3 receptors. ( Andrews, PL; Bhandari, P; Bingham, S, 1992) |
| "The involvement of 5-hydroxytryptamine (5-HT) with cisplatin-induced emesis in the ferret was investigated using reserpine, para-chlorophenylalanine and fenfluramine." | 3.67 | Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret. ( Barnes, JM; Barnes, NM; Costall, B; Naylor, RJ; Tattersall, FD, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alfieri, AB | 1 |
| Cubeddu, LX | 1 |
| Rudd, JA | 1 |
| Cheng, CH | 1 |
| Naylor, RJ | 3 |
| Tanihata, S | 1 |
| Igarashi, H | 1 |
| Suzuki, M | 1 |
| Uchiyama, T | 1 |
| Bhandari, P | 1 |
| Bingham, S | 1 |
| Andrews, PL | 1 |
| Costall, B | 2 |
| Tattersall, FD | 2 |
| Barnes, JM | 1 |
| Barnes, NM | 1 |
1 trial available for fenclonine and Vomiting
| Article | Year |
|---|---|
Treatment with para-chlorophenylalanine antagonises the emetic response and the serotonin-releasing actions of cisplatin in cancer patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fenclonine; Gastrointestin | 1995 |
5 other studies available for fenclonine and Vomiting
| Article | Year |
|---|---|
Serotonin-independent model of cisplatin-induced emesis in the ferret.
Topics: 5-Hydroxytryptophan; Animals; Brain; Cisplatin; Cross-Linking Reagents; Dopamine; Epinephrine; Fencl | 1998 |
Cisplatin-induced early and delayed emesis in the pigeon.
Topics: Adrenergic Uptake Inhibitors; Animals; Antiemetics; Antineoplastic Agents; Brain; Cisplatin; Columbi | 2000 |
The neuropharmacology of loperamide-induced emesis in the ferret: the role of the area postrema, vagus, opiate and 5-HT3 receptors.
Topics: Animals; Behavior, Animal; Cerebral Ventricles; Domperidone; Female; Fenclonine; Ferrets; Loperamide | 1992 |
The actions of fenfluramine and interaction with 5-HT3 receptor-antagonists to inhibit emesis in the ferret.
Topics: Animals; Antiemetics; Cisplatin; Fenclonine; Fenfluramine; Ferrets; Indoles; Male; Metoclopramide; R | 1990 |
Reserpine, para-chlorophenylalanine and fenfluramine antagonise cisplatin-induced emesis in the ferret.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Carnivora; Caudate Nucleus; Cisplatin; Fenclonine; Fe | 1988 |