fenclonine has been researched along with Sleep Initiation and Maintenance Disorders in 41 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therefore, exploring the anti-insomnia effects of volatile oils from HAD is of great importance." | 2.44 | Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice. ( Chen, D; He, C; Li, X; Pu, Y; Shen, M; Wang, M; Zhang, T; Zhou, J, 2024) |
| "AA have certain therapeutic effects on insomnia." | 1.91 | The Effect of Chinese Agarwood Essential Oil with Cyclodextrin Inclusion against PCPA-Induced Insomnia Rats. ( Chen, J; Hua, L; Lai, Y; Li, J; Shi, S; Xu, J; Yang, J; Zhang, S; Zhu, S, 2023) |
| "Insomnia is the most common sleep disorder and is often comorbid with mental and physical diseases." | 1.91 | Electroacupuncture of the cymba concha alleviates p-chlorophenylalanine-induced insomnia in mice. ( Peng, Q; Tang, L; Zhang, F; Zhang, X, 2023) |
| "Primary insomnia was modeled by intraperitoneal injection of para-chlorophenylalanine (PCPA) once daily for 2 d." | 1.91 | Efficacy of electroacupuncture stimulating Shenmen (HT7), Baihui (GV20), Sanyinjiao (SP6) on spatial learning and memory deficits in rats with insomnia induced by para-chlorophenylalanine: a single acupoint combined acupoints. ( Lianhong, T; Lina, Q; Yanshu, J; Yinan, S; Yongsheng, Y, 2023) |
| "In this study, the anti-insomnia efficacy of A." | 1.72 | Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats. ( An, X; Duan, C; Li, C; Li, D; Liu, S; Lv, J; Yao, L; Zhang, C, 2022) |
| "However, the anti-insomnia mechanisms of BLM are still unknown." | 1.56 | The effect of Bailemian on neurotransmitters and gut microbiota in p-chlorophenylalanine induced insomnia mice. ( Chu, W; Gui, Z; Qin, X; Wang, H, 2020) |
| "To reveal the influence of insomnia on the levels of the neurotransmitters including serotonin (5-HT), glutamic acid (Glu), γ-aminobutyric acid (GABA), noradrenaline (NE) and dopamine (DA), and to study the role of ZSS aqueous extract in the treatment of insomnia, an UPLC-ESI- MS/MS method was developed and validated for simultaneous determination of five neurotransmitters in the rat brain." | 1.51 | Determination of five neurotransmitters in the rat brain for the study of the hypnotic effects of Ziziphi Spinosae Semen aqueous extract on insomnia rat model by UPLC-MS/MS. ( DU, CH; DU, HZ; Li, AP; Li, Q; Pei, XP; Qin, XM; Shen, CX; Yan, Y, 2019) |
| "The PCPA-induced insomnia rat model was then applied to confirm the potential targets related to the sedative effects of KL by performing the forced swimming test (FST), the tail suspension test (TST) and the measurement of target-related proteins using western blotting and immunofluorescence." | 1.42 | In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists. ( Feng, X; Hao, Z; Huang, J; Jia, Y; Wang, J; Wu, J; Zhao, S; Zheng, Y, 2015) |
| " The purpose of this study is to compare the pharmacokinetic properties of five protoberberine-type alkaloids (i." | 1.40 | Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan. ( Cai, H; He, W; Hou, W; Liao, Q; Liu, G; Sun, X; Xie, Z; Zhang, P, 2014) |
| "The model of insomnia rats were established by PCPA intraperitoneal injection, after the modeling, all the therapeutic group were treated with corresponding drug for one week." | 1.39 | [Effects of extracts from ziziphi spinosae semen and schisandrae chinensis fructus on amino acid neurotransmitter in rats with insomnia induced by PCPA]. ( Chen, JF; Gao, JR; Ji, WB; Jiang, H, 2013) |
| "In the PCPA-pretreated insomniac rats, PGD2 infusion resulted in an immediate increase in slow-wave sleep (SWS) and an increase with a 2-h latency in paradoxical sleep (PS)." | 1.29 | Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. ( Hayaishi, O; Jouvet, M; Matsumura, H; Nakajima, T; Onoe, H; Sakai, K; Satoh, S, 1994) |
| "5." | 1.27 | Fluctuations in spontaneous discharge of hippocampal theta cells during sleep-waking states and PCPA-induced insomnia. ( Kodama, T; Mushiake, H; Nakahama, H; Shima, K; Yamamoto, M, 1988) |
| "The serotonin-depleting drug, parachlorophenylalanine (PCPA), in a dosage of 300 mg/kg, was administered to rats in an effort to test the hypothesis that altered distribution of PGO waves following drug treatment may be responsible for the sleep disruption and consequent sleep loss that accompany decreased serotonin levels." | 1.27 | PGO waves and insomnia in PCPA-treated rats. ( Marks, GA; Roffwarg, HP, 1988) |
| "We studied the reversibility of this insomnia in physiological slow-wave sleep (SWS) and paradoxical sleep (PS) after 5-hydroxytryptophan (5HTP) and serotonin (5HT) administration." | 1.27 | [Insomnia caused by administration of para-chlorophenylalanine: reversibility by peripheral or central injection of 5-hydroxytryptophan and serotonin]. ( Buda, C; Janin, M; Jouvet, M; Petitjean, F; Sallanon, M, 1985) |
| "injection in PCPA pretreated insomniac cats." | 1.26 | Restoration of paradoxical sleep by cerebrospinal fluid transfer to PCPA pretreated insomniac cats. ( Buda, C; Janin, M; Jouvet, M; Sallanon, M, 1982) |
| "latencies, in insomniac Cats pretreated with P-chlorophenylalanine." | 1.26 | [Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines]. ( Buda, C; Janin, M; Jouvet, M; Petitjean, F; Sallanon, M, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (48.78) | 18.7374 |
| 1990's | 5 (12.20) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (14.63) | 24.3611 |
| 2020's | 10 (24.39) | 2.80 |
| Authors | Studies |
|---|---|
| Si, Y | 1 |
| Chen, X | 2 |
| Guo, T | 1 |
| Wei, W | 1 |
| Wang, L | 1 |
| Zhang, F | 2 |
| Sun, X | 2 |
| Liu, M | 1 |
| Yao, L | 1 |
| Lv, J | 1 |
| Duan, C | 1 |
| An, X | 1 |
| Zhang, C | 1 |
| Li, D | 1 |
| Li, C | 1 |
| Liu, S | 1 |
| Wang, C | 1 |
| Wang, Y | 1 |
| Gong, B | 1 |
| Wu, Y | 1 |
| Liu, Y | 1 |
| Wei, J | 1 |
| Lai, Y | 1 |
| Hua, L | 1 |
| Yang, J | 1 |
| Xu, J | 1 |
| Chen, J | 1 |
| Zhang, S | 1 |
| Zhu, S | 1 |
| Li, J | 2 |
| Shi, S | 1 |
| Zhang, X | 1 |
| Peng, Q | 1 |
| Tang, L | 1 |
| Lina, Q | 1 |
| Yinan, S | 1 |
| Lianhong, T | 1 |
| Yanshu, J | 1 |
| Yongsheng, Y | 1 |
| Li, X | 2 |
| He, C | 1 |
| Shen, M | 1 |
| Wang, M | 1 |
| Zhou, J | 1 |
| Chen, D | 1 |
| Zhang, T | 1 |
| Pu, Y | 1 |
| Yan, Y | 1 |
| Li, Q | 1 |
| DU, HZ | 1 |
| Shen, CX | 1 |
| Li, AP | 1 |
| Pei, XP | 1 |
| DU, CH | 1 |
| Qin, XM | 1 |
| Sun, Y | 2 |
| Zhang, N | 1 |
| Qu, Y | 1 |
| Cao, Y | 1 |
| Yang, Y | 1 |
| Yang, T | 1 |
| Xu, Y | 1 |
| Man, D | 1 |
| Su, X | 1 |
| A, G | 1 |
| Wang, H | 1 |
| Qin, X | 1 |
| Gui, Z | 1 |
| Chu, W | 1 |
| Lin, FJ | 1 |
| Yang, XS | 1 |
| Yang, D | 1 |
| Zou, YQ | 1 |
| Gao, JR | 1 |
| Ji, WB | 1 |
| Jiang, H | 1 |
| Chen, JF | 1 |
| He, W | 1 |
| Liu, G | 1 |
| Cai, H | 1 |
| Hou, W | 1 |
| Zhang, P | 1 |
| Xie, Z | 1 |
| Liao, Q | 1 |
| Zheng, Y | 1 |
| Wu, J | 1 |
| Feng, X | 1 |
| Jia, Y | 1 |
| Huang, J | 1 |
| Hao, Z | 1 |
| Zhao, S | 1 |
| Wang, J | 1 |
| Murray, NM | 1 |
| Buchanan, GF | 1 |
| Richerson, GB | 1 |
| Sallanon, M | 8 |
| Buda, C | 8 |
| Janin, M | 7 |
| Jouvet, M | 13 |
| Laguzzi, RF | 1 |
| Adrien, J | 1 |
| Petitjean, F | 2 |
| Puizillout, JJ | 1 |
| Gaudin-Chazal, G | 1 |
| Sayadi, A | 1 |
| Vigier, D | 1 |
| Satoh, S | 1 |
| Matsumura, H | 1 |
| Nakajima, T | 2 |
| Onoe, H | 1 |
| Sakai, K | 1 |
| Hayaishi, O | 1 |
| Depoortere, H | 1 |
| Francon, D | 1 |
| Granger, P | 1 |
| Terzano, MG | 1 |
| Prospero-García, O | 2 |
| Jiménez-Anguiano, A | 1 |
| Drucker-Colín, R | 2 |
| Sastre, JP | 2 |
| Denoyer, M | 1 |
| Kitahama, K | 1 |
| Aubert, C | 1 |
| Lendais, I | 1 |
| Chaouloff, F | 1 |
| Laude, D | 1 |
| Limoge, A | 1 |
| Elghozi, JL | 1 |
| Seguin, S | 1 |
| Mushiake, H | 1 |
| Kodama, T | 1 |
| Shima, K | 1 |
| Yamamoto, M | 1 |
| Nakahama, H | 1 |
| Touret, M | 1 |
| Marks, GA | 1 |
| Roffwarg, HP | 1 |
| Pujol, JF | 1 |
| Buguet, A | 1 |
| Froment, JL | 1 |
| Jones, B | 1 |
| Van Woert, MH | 1 |
| Ambani, LM | 1 |
| Levine, RJ | 1 |
| Cohen, HB | 1 |
| Dement, WC | 1 |
| Barchas, JD | 1 |
| Henriksen, S | 1 |
| Dement, W | 1 |
| Barchas, J | 1 |
| King, CD | 1 |
3 reviews available for fenclonine and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Serotoninergic mechanisms and sleep.
Topics: Animals; Brain; Cats; Caudate Nucleus; Cerebral Cortex; Electric Stimulation; Electroencephalography | 1981 |
Sleep and serotonin: an unfinished story.
Topics: Animals; Fenclonine; Humans; Raphe Nuclei; Serotonin; Serotonin Antagonists; Sleep; Sleep Initiation | 1999 |
5-Hydroxytryptamine and sleep in the cat: a brief overview.
Topics: Animals; Cats; Chlorine; Electrodes, Implanted; Electroencephalography; Fenclonine; Geniculate Bodie | 1974 |
1 trial available for fenclonine and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Clinical effects of para-chlorophenylalanine in Parkinson's disease.
Topics: Aged; Benztropine; Brain; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; Evaluation S | 1972 |
37 other studies available for fenclonine and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Comprehensive 16S rDNA Sequencing and LC-MS/MS-Based Metabolomics to Investigate Intestinal Flora and Metabolic Profiles of the Serum, Hypothalamus and Hippocampus in p‑Chlorophenylalanine-Induced Insomnia Rats Treated with Lilium brownie.
Topics: Animals; Chromatography, Liquid; DNA, Ribosomal; Fenclonine; Gastrointestinal Microbiome; Hippocampu | 2022 |
Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats.
Topics: Animals; Armillaria; Ecosystem; Fenclonine; Fermentation; Gastrointestinal Microbiome; Rats; Sleep I | 2022 |
Effective Components and Molecular Mechanism of Agarwood Essential Oil Inhalation and the Sedative and Hypnotic Effects Based on GC-MS-Qtof and Molecular Docking.
Topics: Animals; Fenclonine; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutamic Acid; H | 2022 |
The Effect of Chinese Agarwood Essential Oil with Cyclodextrin Inclusion against PCPA-Induced Insomnia Rats.
Topics: Animals; Cyclodextrins; Fenclonine; gamma-Aminobutyric Acid; Neurotransmitter Agents; Oils, Volatile | 2023 |
Electroacupuncture of the cymba concha alleviates p-chlorophenylalanine-induced insomnia in mice.
Topics: Animals; Electroacupuncture; Fenclonine; gamma-Aminobutyric Acid; Hypothalamus; Mice; Sleep Initiati | 2023 |
Efficacy of electroacupuncture stimulating Shenmen (HT7), Baihui (GV20), Sanyinjiao (SP6) on spatial learning and memory deficits in rats with insomnia induced by para-chlorophenylalanine: a single acupoint combined acupoints.
Topics: Acupuncture Points; Animals; Brain-Derived Neurotrophic Factor; Electroacupuncture; Fenclonine; Hipp | 2023 |
Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice.
Topics: Animals; beta-Cyclodextrins; Dopamine; Fenclonine; gamma-Aminobutyric Acid; Hypnotics and Sedatives; | 2024 |
Determination of five neurotransmitters in the rat brain for the study of the hypnotic effects of Ziziphi Spinosae Semen aqueous extract on insomnia rat model by UPLC-MS/MS.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Fenclonine; Hypnotics | 2019 |
Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system.
Topics: Animals; Drugs, Chinese Herbal; Female; Fenclonine; Immunity, Cellular; Male; Mice; Pinellia; Prunel | 2020 |
iTRAQ-based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture.
Topics: Acupuncture Therapy; Animals; Disease Models, Animal; Extracellular Matrix Proteins; Fenclonine; Hum | 2020 |
The effect of Bailemian on neurotransmitters and gut microbiota in p-chlorophenylalanine induced insomnia mice.
Topics: Animals; China; Fenclonine; Gastrointestinal Microbiome; Mice; Neurotransmitter Agents; Sleep Initia | 2020 |
[Expression of cation-chloride cotransporters KCC2 and NKCC1 in brainstem of para- chlorophenylalanine-induced acute insomnia rats].
Topics: Animals; Brain Stem; Disease Models, Animal; Fenclonine; K Cl- Cotransporters; Male; Rats; Rats, Spr | 2013 |
[Effects of extracts from ziziphi spinosae semen and schisandrae chinensis fructus on amino acid neurotransmitter in rats with insomnia induced by PCPA].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Fenclonine; Fruit; gamma-Aminobutyri | 2013 |
Integrated pharmacokinetics of five protoberberine-type alkaloids in normal and insomnic rats after single and multiple oral administration of Jiao-Tai-Wan.
Topics: Administration, Oral; Animals; Berberine Alkaloids; Disease Models, Animal; Dose-Response Relationsh | 2014 |
In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Computer Simulation; Drugs, Chines | 2015 |
Insomnia Caused by Serotonin Depletion is Due to Hypothermia.
Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Confounding Factors, Epidemiologic; F | 2015 |
5-HT antagonists suppress sleep and delay its restoration after 5-HTP in p-chlorophenylalanine-pretreated cats.
Topics: 5-Hydroxytryptophan; Animals; Cats; Female; Fenclonine; Humans; Male; Metergoline; Methiothepin; Ser | 1982 |
Restoration of paradoxical sleep by cerebrospinal fluid transfer to PCPA pretreated insomniac cats.
Topics: Animals; Cats; Cerebrospinal Fluid; Female; Fenclonine; Humans; Male; Sleep Initiation and Maintenan | 1982 |
Serotoninergic mechanisms and sleep rebound.
Topics: Animals; Cats; Female; Fenclonine; Humans; Male; Serotonin; Sleep; Sleep Deprivation; Sleep Initiati | 1983 |
[Inversion of insomnia produced by para-chlorophenylalanine in the rat. Intraperitoneal and intraventricular administration of 5-hydroxytryptophan].
Topics: 5-Hydroxytryptophan; Animals; Fenclonine; Humans; Injections, Intraperitoneal; Injections, Intravent | 1980 |
[Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines].
Topics: 5-Hydroxytryptophan; Animals; Cats; Female; Fenclonine; Humans; Injections, Intraventricular; Male; | 1980 |
[Insomnia induced by p-chlorophenylalanine in the cat. Its reversibility by the intraventricular injection of cerebrospinal fluid taken from cats deprived of paradoxical sleep].
Topics: Animals; Cats; Cerebrospinal Fluid; Female; Fenclonine; Humans; Injections, Intraventricular; Male; | 1981 |
Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine.
Topics: 5-Hydroxytryptophan; Animals; Cerebral Ventricles; Diclofenac; Fenclonine; Male; Prostaglandin D2; R | 1994 |
Evaluation of the stability and quality of sleep using Hjorth's descriptors.
Topics: Animals; Electroencephalography; Fenclonine; Humans; Ibotenic Acid; Magnesium Deficiency; Male; Olfa | 1993 |
The combination of VIP and atropine induces REM sleep in cats rendered insomniac by PCPA.
Topics: Animals; Atropine; Cats; Drug Interactions; Electroencephalography; Female; Fenclonine; Male; Reacti | 1993 |
[Is there a bulbar pacemaker responsible for the ultradian rhythm of paradoxical sleep?].
Topics: Activity Cycles; Animals; Body Temperature; Brain Stem; Cats; Cattle; Cerebral Decortication; Energy | 1995 |
Reversibility of para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of L-5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Cats; Female; Fenclonine; Hypothalamus; Hypothalamus | 1989 |
[Effect of transcranial electrical stimulation on sleep in rats].
Topics: Animals; Brain; Electric Stimulation; Fenclonine; Male; Rats; Rats, Inbred Strains; Serotonin; Sleep | 1989 |
[Systemic or intracerebral injection of bovine neurointermediate lobe extracts may induce paradoxical sleep in insomnia induced by p-chlorophenylalanine in cats].
Topics: Animals; Cats; Fenclonine; Humans; Injections, Intraventricular; Injections, Subcutaneous; Pituitary | 1985 |
Fluctuations in spontaneous discharge of hippocampal theta cells during sleep-waking states and PCPA-induced insomnia.
Topics: Action Potentials; Animals; Cats; Electroencephalography; Fenclonine; Geniculate Bodies; Hippocampus | 1988 |
Microinjection of carbachol into the pontine area is unable to modify insomnia induced by p-cholorophenylalanine (PCPA).
Topics: Animals; Carbachol; Cats; Cholinergic Fibers; Female; Fenclonine; Male; Microinjections; Pons; Serot | 1988 |
[Indolamines and sleep: 5-HT or 5-HTP?].
Topics: 5-Hydroxytryptophan; Animals; Cats; Fenclonine; Rats; Serotonin; Sleep; Sleep Initiation and Mainten | 1988 |
PGO waves and insomnia in PCPA-treated rats.
Topics: Animals; Electric Stimulation; Electroencephalography; Fenclonine; Geniculate Bodies; Male; Occipita | 1988 |
[Insomnia caused by administration of para-chlorophenylalanine: reversibility by peripheral or central injection of 5-hydroxytryptophan and serotonin].
Topics: 5-Hydroxytryptophan; Animals; Brain; Cats; Chloramphenicol; Electroencephalography; Female; Fencloni | 1985 |
The central metabolism of serotonin in the cat during insomnia. A neurophysiological and biochemical study after administration of P-chlorophenylalanine or destruction of the Raphé system.
Topics: 5-Hydroxytryptophan; Animals; Cats; Central Nervous System; Cerebral Cortex; Electroencephalography; | 1971 |
Effects of chlorpromazine on sleep in cats pretreated with para-chlorophenylalanine.
Topics: Animals; Cats; Chlorpromazine; Electrodes, Implanted; Electroencephalography; Electromyography; Elec | 1973 |
The role of serotonin in the regulation of a phasic event of rapid eye movement sleep: the ponto-geniculo-occipital wave.
Topics: Animals; Brain Stem; Cats; Electroencephalography; Fenclonine; Geniculate Bodies; Humans; Occipital | 1974 |