fenclonine has been researched along with Myoclonic Jerk in 6 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam is a potent anticonvulsant 1,4-benzodiazepine that controls some types of myoclonus." | 2.37 | Mechanism of action of clonazepam in myoclonus in relation to effects on GABA and 5-HT. ( Jenner, P; Marsden, CD; Pratt, JA, 1986) |
| "Pretreatment with 5-hydroxytryptophan (5-HTP), a precursor of 5-HT, antagonised while pretreatment with p-chlorophenylalanine (PCPA), a 5-HT depletor, potentiated the myoclonus induced by picrotoxin, a GABA antagonist." | 1.28 | A functional interaction between GABA and 5-HT in inhibiting picrotoxin-induced myoclonus in rats. ( Krishnamoorthy, MS; Paul, V, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (83.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marley, E | 1 |
| Wozniak, KM | 1 |
| Paul, V | 2 |
| Krishnamoorthy, MS | 2 |
| Chadwick, D | 1 |
| Hallett, M | 1 |
| Jenner, P | 2 |
| Marsden, CD | 2 |
| De Léan, J | 1 |
| Richardson, JC | 1 |
| Rewcastle, NB | 1 |
| Pratt, JA | 1 |
1 review available for fenclonine and Myoclonic Jerk
| Article | Year |
|---|---|
Mechanism of action of clonazepam in myoclonus in relation to effects on GABA and 5-HT.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain; Clonazepam | 1986 |
5 other studies available for fenclonine and Myoclonic Jerk
| Article | Year |
|---|---|
Interactions of non-selective monoamine oxidase inhibitors, tranylcypromine and nialamide, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake.
Topics: alpha-Methyltyrosine; Animals; Antidepressive Agents, Tricyclic; Brain Chemistry; Dopamine Antagonis | 1984 |
A functional interaction between GABA and 5-HT in inhibiting picrotoxin-induced myoclonus in rats.
Topics: 5-Hydroxytryptophan; Aminooxyacetic Acid; Animals; Fenclonine; gamma-Aminobutyric Acid; Male; Myoclo | 1990 |
Treatment of posthypoxic action myoclonus: implications for the pathophysiology of the disorder.
Topics: 5-Hydroxytryptophan; Benzodiazepines; Clonazepam; Female; Fenclonine; Humans; Hydroxyindoleacetic Ac | 1986 |
Pathological findings in a case of hypoxic myoclonus treated with 5-hydroxytryptophan and a decarboxylase inhibitor.
Topics: 5-Hydroxytryptophan; Aged; Brain; Carbidopa; Diazepam; Electroencephalography; Female; Fenclonine; H | 1986 |
Evidence for synergism between the antimyoclonic actions of 5-hydroxytryptophan and clonazepam in rats.
Topics: 5-Hydroxytryptophan; Allylglycine; Animals; Cerebral Cortex; Clonazepam; Dose-Response Relationship, | 1988 |