fenclonine has been researched along with Morphine Abuse in 18 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of different manipulations of brain serotonin (5-HT) content on the development of morphine dependence were investigated in rats, which were implanted with morphine pellets for 40 days." | 7.65 | Central serotonergic mechanisms and development of morphine dependence. ( Blasig, J; Gramsch, C; Herz, A; Papeschi, R, 1976) |
| "The effects of different manipulations of brain serotonin (5-HT) content on the development of morphine dependence were investigated in rats, which were implanted with morphine pellets for 40 days." | 3.65 | Central serotonergic mechanisms and development of morphine dependence. ( Blasig, J; Gramsch, C; Herz, A; Papeschi, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (94.44) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fuchs, V | 2 |
| Coper, H | 2 |
| Akaoka, H | 1 |
| Aston-Jones, G | 1 |
| Ho, IK | 3 |
| Brase, DA | 1 |
| Loh, HH | 3 |
| Way, EL | 3 |
| Blasig, J | 1 |
| Papeschi, R | 1 |
| Gramsch, C | 1 |
| Herz, A | 1 |
| Rodríguez, R | 1 |
| Luján, M | 1 |
| Campos, AE | 1 |
| Chroné, R | 1 |
| Bramwell, GJ | 1 |
| Bradley, PB | 1 |
| Berthold, H | 1 |
| Fozard, JR | 1 |
| Engel, G | 1 |
| Maruyama, Y | 1 |
| Hayashi, G | 1 |
| Smits, SE | 1 |
| Takemori, AE | 1 |
| Cheney, DL | 1 |
| Goldstein, A | 1 |
| Algeri, S | 1 |
| Costa, E | 1 |
| Marshall, I | 1 |
| Grahame-Smith, DG | 1 |
| Lu, SE | 1 |
| Stolman, S | 1 |
| Collier, HO | 1 |
| Flórez, J | 1 |
| Delgado, G | 1 |
| Armijo, JA | 1 |
| Davison, K | 1 |
| Osselton, JW | 1 |
| Schwartz, AS | 1 |
| Marchok, PL | 1 |
1 review available for fenclonine and Morphine Abuse
| Article | Year |
|---|---|
Drug dependence: a pharmacological analysis.
Topics: Acetylcholine; Animals; Atropine; Brain Chemistry; Catecholamines; Cerebral Cortex; Chemoreceptor Ce | 1972 |
1 trial available for fenclonine and Morphine Abuse
| Article | Year |
|---|---|
Studies on the relationship between 5-hydroxytryptamine turnover in brain and tolerance and physical dependence in mice.
Topics: Animals; Aspirin; Brain; Cyclazocine; Drug Tolerance; Fenclonine; Humans; Levorphanol; Male; Methado | 1971 |
16 other studies available for fenclonine and Morphine Abuse
| Article | Year |
|---|---|
The influence of p-chlorophenylalanine on different morphine effects.
Topics: Analgesia; Animals; Body Temperature; Brain Chemistry; Dose-Response Relationship, Drug; Fenclonine; | 1980 |
Modification of the drug talking behavior in rats by interference in the metabolism of 5-hydroxytryptamine and catecholamines.
Topics: Animals; Choice Behavior; Disease Models, Animal; Dopamine; Drinking Behavior; Female; Fenclonine; H | 1981 |
Indirect serotonergic agonists attenuate neuronal opiate withdrawal.
Topics: 1-Naphthylamine; Animals; Fenclonine; Fenfluramine; Kynurenine; Locus Coeruleus; Morphine Dependence | 1993 |
Influence of L-tryptophan on morphine analgesia, tolerance and physical dependence.
Topics: Analgesia; Animals; Brain; Drug Interactions; Drug Tolerance; Fenclonine; Humans; Male; Mice; Mice, | 1975 |
Central serotonergic mechanisms and development of morphine dependence.
Topics: 5,6-Dihydroxytryptamine; Animals; Brain Chemistry; Cyproheptadine; Fenclonine; Humans; Injections, I | 1976 |
Morphine dependence in the isolated guinea-pig ileum and its modification by p-chlorophenylalanine.
Topics: Animals; Female; Fenclonine; Guinea Pigs; Humans; Ileum; Male; Morphine Dependence; Muscle Contracti | 1978 |
Effects of morphine on brainstem neurones in naive and chronic morphine-treated rats, and effects of PCPA.
Topics: Animals; Brain Stem; Drinking; Eating; Fenclonine; Humans; Male; Morphine; Morphine Dependence; Moto | 1978 |
5-HT1 receptor agonists attenuate the naloxone-induced jumping behaviour in morphine-dependent mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Ani | 1989 |
Brain 5-hydroxytryptamine and cyclic AMP in morphine tolerance and dependence.
Topics: 5-Hydroxytryptophan; Adrenergic beta-Antagonists; Analgesics; Animals; Body Weight; Brain; Brain Che | 1974 |
The effect of p-chlorophenylalanine on opiate-induced running, analgesia, tolerance and physical dependence in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Behavior, Animal; Brain Chemistry; Drug Tolerance; Fencloni | 1971 |
Physical dependence on morphine fails to increase serotonin turnover rate in rat brain.
Topics: Animals; Body Temperature; Brain; Carbon Isotopes; Fenclonine; Humans; Male; Mathematics; Morphine D | 1971 |
Evidence against a role of brain 5-hydroxytryptamine in the development of physical dependence upon morphine in mice.
Topics: Animals; Body Weight; Brain Chemistry; Drug Interactions; Female; Fenclonine; Humans; Kinetics; Mice | 1971 |
Influence of p-chlorophenylalanine on morphine tolerance and physical dependence and regional brain serotonin turnover studies in morphine tolerant-dependent mice.
Topics: Analgesia; Animals; Body Weight; Brain Chemistry; Brain Stem; Drug Tolerance; Fenclonine; Humans; Hy | 1972 |
Brain amines and development of acute tolerance to and dependence on morphine in the respiratory center of decerebrate cats.
Topics: Amines; Animals; Blood Pressure; Carbon Dioxide; Cats; Decerebrate State; Drug Tolerance; Fenclonine | 1973 |
Parachlorophenylalanine, serotonin and sleep.
Topics: Animals; Drug Tolerance; Fenclonine; Humans; Methadone; Mice; Morphine Dependence; Rats; Serotonin; | 1973 |
Depression of morphine-seeking behaviour by dopamine inhibition.
Topics: Animals; Chelating Agents; Conditioning, Operant; Dopamine Antagonists; Dopamine beta-Hydroxylase; F | 1974 |