fenclonine has been researched along with Injuries, Spinal Cord in 20 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pretreatment with p-chlorophenylalanine, indomethacin, ibuprofen, and nimodipine attenuated the SCEP changes immediately after trauma and resulted in a marked reduction in edema formation, BSCB permeability, and blood flow changes at 5 h." | 3.71 | Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. ( Sharma, HS; Winkler, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 14 (70.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, HS | 14 |
| Winkler, T | 3 |
| Westman, J | 5 |
| Fujiki, M | 1 |
| Kobayashi, H | 1 |
| Inoue, R | 1 |
| Ishii, K | 1 |
| Olsson, Y | 10 |
| Cervós-Navarro, J | 2 |
| Nyberg, F | 4 |
| Thörnwall, M | 1 |
| Stålberg, E | 2 |
| Badgaiyan, RD | 1 |
| Alm, P | 1 |
| Hadley, SD | 2 |
| Walker, PD | 2 |
| Goshgarian, HG | 2 |
| Gordh, T | 1 |
| Nĕmecek, S | 1 |
| Petr, R | 1 |
| Suba, P | 1 |
| Rozsíval, V | 1 |
| Pettersson, A | 1 |
| Dey, PK | 3 |
| Hashimoto, T | 1 |
| Fukuda, N | 1 |
| Pettersson, CA | 1 |
| Johansson, O | 1 |
| Garelis, E | 1 |
| Young, SN | 1 |
| Lal, S | 1 |
| Sourkes, TL | 1 |
1 review available for fenclonine and Injuries, Spinal Cord
| Article | Year |
|---|---|
Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies.
Topics: Animals; Biological Transport, Active; Brain; Cats; Cerebral Ventricles; Cerebrospinal Fluid; Choroi | 1974 |
19 other studies available for fenclonine and Injuries, Spinal Cord
| Article | Year |
|---|---|
Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Anti-I | 2002 |
Depletion of endogenous serotonin synthesis with p-CPA attenuates upregulation of constitutive isoform of heme oxygenase-2 expression, edema formation and cell injury following a focal trauma to the rat spinal cord.
Topics: Animals; Edema; Fenclonine; Heat-Shock Proteins; Heme Oxygenase (Decyclizing); HSP72 Heat-Shock Prot | 2003 |
Immediate plasticity in the motor pathways after spinal cord hemisection: implications for transcranial magnetic motor-evoked potentials.
Topics: Animals; Efferent Pathways; Electric Stimulation; Evoked Potentials, Motor; Female; Fenclonine; Func | 2004 |
A serotonin synthesis inhibitor, p-chlorophenylalanine reduces the heat shock protein response following trauma to the spinal cord: an immunohistochemical and ultrastructural study in the rat.
Topics: Animals; Blood Pressure; Body Temperature; Fenclonine; HSP70 Heat-Shock Proteins; Immunohistochemist | 1995 |
p-Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord. An immunohistochemical investigation in the rat.
Topics: Animals; Blood Pressure; Fenclonine; Glial Fibrillary Acidic Protein; Male; Rats; Rats, Wistar; Sero | 1993 |
Met-enkephalin-Arg6-Phe7 in spinal cord and brain following traumatic injury to the spinal cord: influence of p-chlorophenylalanine. An experimental study in the rat using radioimmunoassay technique.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Fenclonine; | 1993 |
Spinal cord evoked potentials and edema in the pathophysiology of rat spinal cord injury. Involvement of nitric oxide.
Topics: Animals; Diazepam; Edema; Enzyme Inhibitors; Evoked Potentials; Fenclonine; Male; NG-Nitroarginine M | 1998 |
Effects of serotonin inhibition on neuronal and astrocyte plasticity in the phrenic nucleus 4 h following C2 spinal cord hemisection.
Topics: Animals; Astrocytes; Axons; Dendrites; Female; Fenclonine; Glial Fibrillary Acidic Protein; Immunohi | 1999 |
Effects of the serotonin synthesis inhibitor p-CPA on the expression of the crossed phrenic phenomenon 4 h following C2 spinal cord hemisection.
Topics: Animals; Asphyxia; Chromatography, High Pressure Liquid; Dopamine; Female; Fenclonine; Functional La | 1999 |
Spinal cord injury induced c-fos expression is reduced by p-CPA, a serotonin synthesis inhibitor. An experimental study using immunohistochemistry in the rat.
Topics: Animals; Edema; Fenclonine; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Seroton | 2000 |
Attempt to influence pharmacologically spinal cord tissue changes after an experimental injury.
Topics: Animals; Aprotinin; Disease Models, Animal; Female; Fenclonine; Male; Methyltyrosines; Rabbits; Spin | 1975 |
Dynorphin A content in the rat brain and spinal cord after a localized trauma to the spinal cord and its modification with p-chlorophenylalanine. An experimental study using radioimmunoassay technique.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Dynorphins; Fenclonine; Male; Radioi | 1992 |
Release of endogenous neurochemicals may increase vascular permeability, induce edema and influence cell changes in trauma to the spinal cord.
Topics: Animals; Blood Pressure; Body Water; Brain Edema; Capillary Permeability; Carbon Dioxide; Fenclonine | 1992 |
Alteration of substance P after trauma to the spinal cord: an experimental study in the rat.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Fenclonine; Rats; Rats, Inbred Strains; Refere | 1990 |
Contribution of serotonin neurons to the functional recovery after spinal cord injury in rats.
Topics: 5,7-Dihydroxytryptamine; Animals; Biogenic Monoamines; Dopamine; Fenclonine; Injections, Intraventri | 1991 |
Evaluation of traumatic spinal cord edema using evoked potentials recorded from the spinal epidural space. An experimental study in the rat.
Topics: Animals; Cyproheptadine; Edema; Epidural Space; Evoked Potentials; Fenclonine; Male; Rats; Rats, Inb | 1991 |
Edema formation and cellular alterations following spinal cord injury in the rat and their modification with p-chlorophenylalanine.
Topics: Animals; Edema; Fenclonine; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Serotonin; Spina | 1990 |
Effects of p-chlorophenylalanine on microvascular permeability changes in spinal cord trauma. An experimental study in the rat using 131I-sodium and lanthanum tracers.
Topics: Animals; Capillary Permeability; Fenclonine; Lanthanum; Male; Rats; Rats, Inbred Strains; Serotonin; | 1990 |
Increased 5-hydroxytryptamine immunoreactivity in traumatized spinal cord. An experimental study in the rat.
Topics: Animals; Fenclonine; Immunohistochemistry; Rats; Rats, Inbred Strains; Serotonin; Spinal Cord Injuri | 1990 |