fenclonine has been researched along with Hypothyroidism in 8 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neonatal hypothyroidism is known to induce the accumulation of substance P and serotonin in many discrete brain nuclei of the rat." | 3.67 | The effects of p-chlorophenylalanine (PCPA) treatment on the substance P content measured in discrete brain nuclei of normal and neonatally-induced hypothyroid rats. ( Dupont, A; Mérand, Y; Savard, P, 1984) |
| "In both cases, prior induction of primary hypothyroidism interfered with the expected diabetes-induced reduction in 5-HT turnover." | 1.28 | Streptozotocin-induced decreases in serotonin turnover are prevented by thyroidectomy. ( Bellush, LL; Henley, WN, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Savard, P | 3 |
| Mérand, Y | 3 |
| Bédard, P | 1 |
| Dussault, JH | 1 |
| Dupont, A | 3 |
| Di Paolo, T | 1 |
| Walker, RF | 2 |
| Timiras, PS | 2 |
| Männistö, PT | 1 |
| Ranta, T | 1 |
| Henley, WN | 1 |
| Bellush, LL | 1 |
| Boiadzhieva, N | 1 |
8 other studies available for fenclonine and Hypothyroidism
| Article | Year |
|---|---|
Comparative effects of neonatal hypothyroidism and euthyroidism on TRH and substance P content of lumbar spinal cord in saline and PCPA-treated rats.
Topics: Animals; Fenclonine; Ganglia, Spinal; Hypothyroidism; Male; Neurons; Rats; Rats, Inbred Strains; Rec | 1983 |
The effects of p-chlorophenylalanine (PCPA) treatment on the substance P content measured in discrete brain nuclei of normal and neonatally-induced hypothyroid rats.
Topics: Animals; Animals, Newborn; Brain Chemistry; Fenclonine; Hypothyroidism; Rats; Rats, Inbred Strains; | 1984 |
Effect of neonatal hypothyroidism on the serotonin system of the rat brain.
Topics: Animals; Animals, Newborn; Brain Chemistry; Fenclonine; Hydroxyindoleacetic Acid; Hypothyroidism; Io | 1984 |
Loss of serotonin circadian rhythms in the pineal gland of androgenized female rats.
Topics: Aging; Animals; Circadian Rhythm; Estrus; Female; Fenclonine; Hypothyroidism; Luteinizing Hormone; P | 1980 |
Serotonin in development of cyclic reproductive function.
Topics: Animals; Circadian Rhythm; Dopamine; Estrogens; Female; Fenclonine; Hypothalamus; Hypothyroidism; Li | 1981 |
Neurotransmitter control of thyrotrophin secretion in hypothyroid rats.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Bromocriptine; Clonidine; Ditiocarb; Fenclonine; Hypothyr | 1978 |
Streptozotocin-induced decreases in serotonin turnover are prevented by thyroidectomy.
Topics: Animals; Corticosterone; Diabetes Mellitus, Experimental; Exploratory Behavior; Fenclonine; Hydroxyi | 1992 |
[Effect of serotoninergic agents on the thyrotropic function of the adenohypophysis].
Topics: 5-Hydroxytryptophan; Animals; Cold Temperature; Fenclonine; Hypothyroidism; Male; Methysergide; Pitu | 1987 |