fenclonine has been researched along with Hypothermia in 19 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective of this study was to investigate the mechanism of brain monoamine metabolism in taurine-induced hypothermia and appetite suppression." | 8.12 | Intracerebroventricular injection of taurine induces hypothermia through modifying monoaminergic pathways in chicks. ( Bungo, T; Chowdhury, VS; Cline, MA; Elhussiny, MZ; Furuse, M; Gilbert, ER; Haraguchi, S; Nishimura, H; Tran, PV, 2022) |
| "Depressing functional serotonin or depleting serotonin levels in rat brains with either p-chlorophenylalanine, 5,6-dihydroxytryptamine or raphe lesions greatly enhanced hypothermia induced by chloropromazine (CPZ)." | 7.66 | Effects of brain serotonin alterations on hypothermia produced by chlorpromazine in rats. ( Chern, YF; Chow, CF; Li, YP; Lin, MT, 1979) |
| "Intraventricular administration of taurine in the rat caused hypothermia, the extent of which was directly dependent upon the thermal gradient between the body and the environment." | 7.65 | Is taurine-induced hypothermia in the rat mediated by 5-HT? ( Galli, A; Pavàn, F; Sgaragli, GP, 1975) |
| " The objective of this study was to investigate the mechanism of brain monoamine metabolism in taurine-induced hypothermia and appetite suppression." | 4.12 | Intracerebroventricular injection of taurine induces hypothermia through modifying monoaminergic pathways in chicks. ( Bungo, T; Chowdhury, VS; Cline, MA; Elhussiny, MZ; Furuse, M; Gilbert, ER; Haraguchi, S; Nishimura, H; Tran, PV, 2022) |
| " However, single treatment with XBXT-2 had no effect on yohimbine toxicity and high dose of apomorphine-induced hypothermia in mice." | 3.74 | Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang. ( An, L; Li, YF; Liu, XM; Yu, NJ; Yuan, L; Zhang, YZ; Zhao, N, 2008) |
| "5]- decane-7,9-dione (BMY 7378) (5 mg/kg) did not significantly depress body temperature, but pretreatment with BMY 7378 blocked hypothermia induced by the selective 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)." | 3.68 | Serotonin 5-HT1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance. ( Bohmaker, K; Chalfin, M; Meller, E, 1992) |
| "Depressing functional serotonin or depleting serotonin levels in rat brains with either p-chlorophenylalanine, 5,6-dihydroxytryptamine or raphe lesions greatly enhanced hypothermia induced by chloropromazine (CPZ)." | 3.66 | Effects of brain serotonin alterations on hypothermia produced by chlorpromazine in rats. ( Chern, YF; Chow, CF; Li, YP; Lin, MT, 1979) |
| "Intraventricular administration of taurine in the rat caused hypothermia, the extent of which was directly dependent upon the thermal gradient between the body and the environment." | 3.65 | Is taurine-induced hypothermia in the rat mediated by 5-HT? ( Galli, A; Pavàn, F; Sgaragli, GP, 1975) |
| "3 A second cannabis extract (II) with a different ratio of cannabinoids (also administered in dosage equivalent to 10 mg Delta(9)-THC/kg) failed to affect pentobarbitone anaesthesia in mice." | 1.25 | Interaction of cannabis and general anaesthetic agents in mice. ( Chesher, GB; Jackson, DM; Starmer, GA, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (57.89) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Elhussiny, MZ | 1 |
| Nishimura, H | 1 |
| Tran, PV | 1 |
| Haraguchi, S | 1 |
| Gilbert, ER | 1 |
| Cline, MA | 1 |
| Bungo, T | 1 |
| Furuse, M | 1 |
| Chowdhury, VS | 1 |
| Murray, NM | 1 |
| Buchanan, GF | 1 |
| Richerson, GB | 1 |
| Xu, Y | 1 |
| Wang, Z | 1 |
| You, W | 1 |
| Zhang, X | 1 |
| Li, S | 1 |
| Barish, PA | 1 |
| Vernon, MM | 1 |
| Du, X | 1 |
| Li, G | 1 |
| Pan, J | 1 |
| Ogle, WO | 1 |
| An, L | 1 |
| Zhang, YZ | 1 |
| Yu, NJ | 1 |
| Liu, XM | 1 |
| Zhao, N | 1 |
| Yuan, L | 1 |
| Li, YF | 1 |
| Tamura, H | 1 |
| Amar, A | 1 |
| Sanyal, AK | 1 |
| Revelis, J | 1 |
| Thompson, AM | 1 |
| Britton, BH | 1 |
| Thompson, GC | 1 |
| Cryan, JF | 1 |
| Harkin, A | 1 |
| Naughton, M | 1 |
| Kelly, JP | 1 |
| Leonard, BE | 2 |
| Sgaragli, GP | 1 |
| Pavàn, F | 1 |
| Galli, A | 1 |
| Janoff, AS | 1 |
| Rosenberg, B | 1 |
| Lin, MT | 1 |
| Chern, YF | 1 |
| Chow, CF | 1 |
| Li, YP | 1 |
| Meller, E | 1 |
| Chalfin, M | 1 |
| Bohmaker, K | 1 |
| Komissarov, IV | 1 |
| Dolzhenko, AT | 1 |
| Obraztsova, OG | 1 |
| Zin'kovskaia, LIa | 1 |
| Bruinvels, J | 1 |
| Kemper, GC | 1 |
| Shallice, SA | 1 |
| Grabowska, M | 1 |
| Michaluk, J | 1 |
| Antkiewicz, L | 1 |
| Fahim, I | 1 |
| Ismail, M | 1 |
| Osman, OH | 1 |
| Ahtee, L | 1 |
| Jounela, AJ | 1 |
| Saarnivaara, L | 1 |
| Simola, I | 1 |
| Chesher, GB | 1 |
| Jackson, DM | 1 |
| Starmer, GA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder - Fear of Harm Phenotype[NCT05209217] | 20 participants (Anticipated) | Observational | 2019-06-04 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 other studies available for fenclonine and Hypothermia
| Article | Year |
|---|---|
Intracerebroventricular injection of taurine induces hypothermia through modifying monoaminergic pathways in chicks.
Topics: Animals; Chickens; Dopamine; Eating; Fenclonine; Hypothermia; Male; Norepinephrine; Serotonin; Tauri | 2022 |
Insomnia Caused by Serotonin Depletion is Due to Hypothermia.
Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Confounding Factors, Epidemiologic; F | 2015 |
Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system.
Topics: Animals; Antidepressive Agents; Antioxidants; Apomorphine; Behavior, Animal; Brain Chemistry; Depres | 2010 |
Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang.
Topics: Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Depression; Disease Models, Animal; D | 2008 |
[The mechanisms of antagonistic action of prostaglandin E1 against As2O3-induced hypothermia].
Topics: alpha-Methyltyrosine; Alprostadil; Animals; Arsenic; Arsenic Trioxide; Arsenicals; Bis(4-Methyl-1-Ho | 1984 |
Immobilization stress in rats: effect on rectal temperature and possible role of brain monoamines in hypothermia.
Topics: 5,6-Dihydroxytryptamine; Adrenalectomy; Animals; Biogenic Amines; Brain Chemistry; Dopamine; Fenclon | 1981 |
Effects of para-chlorophenylalanine (pCPA) on the bush baby auditory brainstem response.
Topics: Animals; Auditory Pathways; Evoked Potentials, Auditory, Brain Stem; Female; Fenclonine; Galago; Hyp | 1998 |
Characterization of D-fenfluramine-induced hypothermia: evidence for multiple sites of action.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzofurans; Body Temperature; Cerebral | 2000 |
Is taurine-induced hypothermia in the rat mediated by 5-HT?
Topics: Animals; Brain Chemistry; Depression, Chemical; Female; Fenclonine; Hypothermia; Methyltyrosines; Ra | 1975 |
Chemically evoked hypothermia in the mouse: towards a method for investigating thermodynamic parameters of aging and death in mammals.
Topics: Adaptation, Physiological; Aging; Animals; Chlorpromazine; Drug Synergism; Female; Fenclonine; Hypot | 1978 |
Effects of brain serotonin alterations on hypothermia produced by chlorpromazine in rats.
Topics: 5-Hydroxytryptophan; 5,6-Dihydroxytryptamine; Animals; Body Temperature Regulation; Brain; Chlorprom | 1979 |
Serotonin 5-HT1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Body Temperature; Col | 1992 |
[An analysis of the hypothermic action of 8-hydroxy-2-(di-N-propylamino)tetralin, 1-(2-pyrimidinyl)piperazine and its derivatives].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Buspirone; Dose-Response Relation | 1990 |
Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat.
Topics: Animals; Body Temperature; Drug Synergism; Fenclonine; Fever; Hypothalamus; Hypothermia; Injections, | 1971 |
The effects of some tryptamine derivatives on brain monoamines and their precursor amino acids.
Topics: Amines; Amino Acids; Aminobutyrates; Animals; Behavior, Animal; Brain; Brain Chemistry; Circadian Rh | 1972 |
Possible involvement of brain serotonin in apomorphine-induced hypothermia.
Topics: Animals; Apomorphine; Body Temperature; Brain Chemistry; Butyrophenones; Drug Interactions; Fencloni | 1973 |
Role of 5-hydroxytryptamine in ketamine-induced hypothermia in the rat.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Brain; Dose-Response Relationship, Drug; Ergotamine; | 1973 |
Interactions of some analgesics and antidepressants with phenelzine or reserpine in the mouse.
Topics: Alphaprodine; Analgesics; Animals; Antidepressive Agents; Body Temperature; Drug Interactions; Fencl | 1974 |
Interaction of cannabis and general anaesthetic agents in mice.
Topics: Anesthesia, General; Animals; Cannabis; Desipramine; Dronabinol; Drug Synergism; Ethyl Ethers; Fencl | 1974 |