fenclonine has been researched along with Hypoglycemia in 3 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Hypoglycemia: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After administration of cyproheptadine (16 mg daily, for two days) the glucagon responses to arginine (N=12) and to insulin-induced hypoglycemia (N=9) were more marked than in the control experiments (differences between maximal elevations: +165 pg/ml, P less than 0." | 3.65 | Potentiation of glucagon secretion by serotonin antagonists in man. ( Calle, C; Hedo, JA; Marco, J; Martinell, J; Villanueva, ML, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, SL | 1 |
| Tsai, CC | 1 |
| Lin, JG | 1 |
| Hsieh, CL | 1 |
| Lin, RT | 1 |
| Cheng, JT | 1 |
| Marco, J | 1 |
| Hedo, JA | 1 |
| Martinell, J | 1 |
| Calle, C | 1 |
| Villanueva, ML | 1 |
| Smith, SA | 1 |
| Pogson, CL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Improving Insulin Sensitivity by Combined Both Electroacupuncture and Drug Therapy[NCT00379379] | 26 participants | Interventional | 2005-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for fenclonine and Hypoglycemia
| Article | Year |
|---|---|
Involvement of serotonin in the hypoglycemic response to 2 Hz electroacupuncture of zusanli acupoint (ST36) in rats.
Topics: Acupuncture Points; Analysis of Variance; Animals; beta-Endorphin; Blood Glucose; Drug Interactions; | 2005 |
Potentiation of glucagon secretion by serotonin antagonists in man.
Topics: Arginine; Cyproheptadine; Fenclonine; Glucagon; Humans; Hypoglycemia; Insulin; Methysergide; Seroton | 1976 |
Tryptophan and the control of plasma glucose concentrations in the rat.
Topics: 5-Hydroxytryptophan; Adrenalectomy; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fenclon | 1977 |