fenclonine has been researched along with Hypertension, Pulmonary in 6 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have studied the role of 5-hydroxytryptamine (5-HT) in monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats using p-chlorophenylalanine (PCPA) which inhibits 5-HT synthesis." | 7.67 | Pulmonary hypertension induced in rats by monocrotaline and chronic hypoxia is reduced by p-chlorophenylalanine. ( Kay, JM; Keane, PM; Suyama, KL, 1985) |
| "We have studied the role of 5-hydroxytryptamine (5-HT) in monocrotaline pulmonary hypertension and chronic hypoxic pulmonary hypertension in rats using p-chlorophenylalanine (PCPA) which inhibits 5-HT synthesis." | 3.67 | Pulmonary hypertension induced in rats by monocrotaline and chronic hypoxia is reduced by p-chlorophenylalanine. ( Kay, JM; Keane, PM; Suyama, KL, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bai, Y | 2 |
| Li, ZX | 1 |
| Wang, HL | 2 |
| Lian, GC | 2 |
| Wang, Y | 2 |
| Wang, HM | 1 |
| Liu, M | 1 |
| Zhang, XH | 1 |
| Kang, J | 1 |
| Izikki, M | 1 |
| Hanoun, N | 1 |
| Marcos, E | 1 |
| Savale, L | 1 |
| Barlier-Mur, AM | 1 |
| Saurini, F | 1 |
| Eddahibi, S | 1 |
| Hamon, M | 1 |
| Adnot, S | 1 |
| Tucker, A | 1 |
| Bryant, SE | 1 |
| Frost, HH | 1 |
| Migally, N | 1 |
| Kay, JM | 1 |
| Keane, PM | 1 |
| Suyama, KL | 1 |
| Lüllmann, H | 1 |
| Parwaresch, MR | 1 |
| Sattler, M | 1 |
| Seiler, KU | 1 |
| Siegfriedt, A | 1 |
6 other studies available for fenclonine and Hypertension, Pulmonary
| Article | Year |
|---|---|
The protective effects of PCPA against monocrotaline-induced pulmonary arterial hypertension are mediated through the downregulation of NFAT-1 and NF-κB.
Topics: Animals; Disease Models, Animal; Fenclonine; Hypertension, Pulmonary; Male; Monocrotaline; NFATC Tra | 2017 |
4-Chloro-DL-phenylalanine protects against monocrotaline‑induced pulmonary vascular remodeling and lung inflammation.
Topics: Animals; Disease Models, Animal; Down-Regulation; Familial Primary Pulmonary Hypertension; Fenclonin | 2014 |
Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice.
Topics: Animals; Chronic Disease; Enzyme Inhibitors; Fenclonine; Hypertension, Pulmonary; Hypoxia; Intestina | 2007 |
Chemical sympathectomy and serotonin inhibition reduce monocrotaline-induced right ventricular hypertrophy in rats.
Topics: Animals; Cardiomegaly; Fenclonine; Hydroxydopamines; Hypertension, Pulmonary; Lung; Male; Monocrotal | 1983 |
Pulmonary hypertension induced in rats by monocrotaline and chronic hypoxia is reduced by p-chlorophenylalanine.
Topics: Animals; Chronic Disease; Female; Fenclonine; Hypertension, Pulmonary; Hypoxia; Monocrotaline; Pyrro | 1985 |
The effects of anorectic agents on the pulmonary pressure and morphology of rat lungs after chronic administration.
Topics: Animals; Appetite Depressants; Blood Pressure; Carotid Arteries; Chlorphentermine; Ephedrine; Fenclo | 1972 |