Page last updated: 2024-11-02

fenclonine and Fever

fenclonine has been researched along with Fever in 29 studies

Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

ExcerptRelevanceReference
"Tranylcypromine (TCP), a monoamine oxidase inhibitor, caused a fatal hyperpyrexia in rats pretreated with LiCl once a day for 4 days."7.66Role of brain amines in the fetal hyperpyrexia caused by tranylcypromine in LiCl-pretreated rats. ( Hashimoto, M; Honda, F; Mori, J; Shimomura, K, 1979)
"Tranylcypromine (TCP), a monoamine oxidase inhibitor, caused a fatal hyperpyrexia in rats pretreated with LiCl once a day for 4 days."3.66Role of brain amines in the fetal hyperpyrexia caused by tranylcypromine in LiCl-pretreated rats. ( Hashimoto, M; Honda, F; Mori, J; Shimomura, K, 1979)
" The hyperactivity and hyperpyrexia produced by L-tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by chlorpromazine."3.65Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor. ( Grahame-Smith, DG, 1971)
" Blood samples for analysis of glucose and lactate were taken at 30-45 min intervals before and after drug dosing and body temperature was monitored by telemetry."1.34Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats. ( Cumming, P; Gramsbergen, JB, 2007)
"2."1.26Contrasting roles of 5-hydroxytryptamine and noradrenaline in fever in rats. ( Ford, DM; Klugman, KP, 1980)
"Indomethacin pretreatment prevented the first part of the febrile response and only a slight temperature rise occurred after a long latency."1.26Endotoxin fever in the newborn kitten. The role of prostaglandins and monoamines. ( Székely, M, 1979)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199023 (79.31)18.7374
1990's2 (6.90)18.2507
2000's3 (10.34)29.6817
2010's1 (3.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gannon, BM1
Williamson, A1
Rice, KC1
Fantegrossi, WE1
Saadat, KS1
O'shea, E1
Colado, MI1
Elliott, JM1
Green, AR1
Gramsbergen, JB1
Cumming, P1
Konusova, AV1
Popova, NK1
Ford, DM1
Klugman, KP1
Sgaragli, G1
Carlà, V1
Magnani, M1
Galli, A1
Nicolodi, M1
Sicuteri, F2
Sugimoto, Y1
Ohkura, M1
Inoue, K1
Yamada, J1
Metcalf, G1
Thompson, JW1
Cronin, MJ1
Borsook, D1
Laburn, HP1
Rosendorff, C1
Willies, GH1
Woolf, CJ1
Lin, MT1
Székely, M3
Panaretto, BA1
Bantutova, I1
Shimomura, K1
Hashimoto, M1
Mori, J1
Honda, F1
Lecci, A1
Borsini, F1
Mancinelli, A1
D'Aranno, V1
Stasi, MA1
Volterra, G1
Meli, A1
Grahame-Smith, DG2
Gong, SN1
Rogers, KJ1
Bruinvels, J1
Kemper, GC1
Peters, DA1
Hrdina, PD1
Singhal, RL1
Ling, GM1
Masek, K1
Rasková, H1
Rotta, J1
Osman, OH1
Ismail, M1
Wenger, T1
Anselmi, B1
Franchi, G1
Fanciullacci, M1
Del Bianco, PL1
Harvey, CA1
Milton, AS1
Sinclair, JG1
Chaplin, MF1

Other Studies

29 other studies available for fenclonine and Fever

ArticleYear
Role of monoaminergic systems and ambient temperature in bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV)-elicited hyperthermia and locomotor stimulation in mice.
    Neuropharmacology, 2018, 05-15, Volume: 134, Issue:Pt A

    Topics: alpha-Methyltyrosine; Analysis of Variance; Animals; Benzodioxoles; Biogenic Monoamines; Body Temper

2018
The role of 5-HT in the impairment of thermoregulation observed in rats administered MDMA ('ecstasy') when housed at high ambient temperature.
    Psychopharmacology, 2005, Volume: 179, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biogenic Monoamines; Body Temperature Regulation; B

2005
Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats.
    Neurochemistry international, 2007, Volume: 51, Issue:1

    Topics: Animals; Body Temperature; Corpus Striatum; Dose-Response Relationship, Drug; Energy Metabolism; Ext

2007
[Role of central and peripheral serotoninergic mechanisms].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1982, Volume: 68, Issue:10

    Topics: Animals; Body Temperature; Body Temperature Regulation; Brain; Cyproheptadine; Fenclonine; Fever; In

1982
Contrasting roles of 5-hydroxytryptamine and noradrenaline in fever in rats.
    The Journal of physiology, 1980, Volume: 304

    Topics: Animals; Body Temperature; Body Temperature Regulation; Endotoxins; Fenclonine; Fever; Hydroxydopami

1980
Hypothermia induced in rabbits by intracerebroventricular taurine: specificity and relationships with central serotonin (5-HT) systems.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:3

    Topics: Animals; Body Temperature Regulation; Brain Chemistry; Clomipramine; Fenclonine; Fever; Fluoxetine;

1981
Eosinophilia myalgia syndrome. The role of contaminants, the role of serotonergic metabolism set up.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Drug Contamination; Eosinophilia-Myalgia Syndrome; Female; Fenclonine; Fever; Humans; Male; Migraine

1996
Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: alpha-Methyltyrosine; Animals; Benzazepines; Body Temperature; Dopamine Antagonists; Enzyme Inhibito

2001
The effect of various amine-depleting drugs on the fever response exhibited by rabbits to bacterial or leucocyte pyrogen.
    British journal of pharmacology, 1975, Volume: 53, Issue:1

    Topics: Amines; Animals; Body Temperature Regulation; Epinephrine; Female; Fenclonine; Fever; Hypothalamus;

1975
p-Chlorophenylalanine hyperthermia in a warm environment: reversal with 5-hydroxytryptophan.
    Brain research, 1976, Aug-06, Volume: 112, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Body Temperature Regulation; Female; Fenclonine; Fever; Hot Temperatur

1976
A dissociation between temperature regulation and fever in the rabbit.
    The Journal of physiology, 1977, Volume: 266, Issue:2

    Topics: Animals; Body Temperature Regulation; Female; Fenclonine; Fever; Hypothalamus; Male; Prostaglandins

1977
Prostaglandin E1-induced fever in rabbits pretreated with p-chlorophenylalanine.
    Experientia, 1978, Jan-15, Volume: 34, Issue:1

    Topics: Animals; Fenclonine; Fever; Prostaglandins E; Rabbits

1978
Endotoxin fever in para-chlorophenylalanine (PCPA) treated newborn guinea pigs and kittens.
    Life sciences, 1978, May-08, Volume: 22, Issue:18

    Topics: Animals; Animals, Newborn; Cats; Drug Synergism; Endotoxins; Escherichia coli; Fenclonine; Fever; Gu

1978
Endotoxin fever in the new-born guinea-pig and the modulating effects of indomethacin and p-chlorophenylalanine.
    The Journal of physiology, 1978, Volume: 281

    Topics: Animals; Animals, Newborn; Body Temperature; Endotoxins; Escherichia coli; Fenclonine; Fever; Guinea

1978
Pimozide and p-chlorophenylalanine blockade in DL-amphetamine and pargyline-treated rats held at two environmental temperatures.
    Experientia, 1979, Sep-15, Volume: 35, Issue:9

    Topics: Amphetamines; Animals; Body Temperature; Fenclonine; Fever; Male; Pargyline; Pimozide; Rats; Tempera

1979
[Effect of pharmacological agents and coagulation of the n. raphe dorsalis on morphine effects].
    Eksperimentalna meditsina i morfologiia, 1979, Volume: 18, Issue:4

    Topics: Animals; Brain Stem; Catalepsy; Cyproheptadine; Dimenhydrinate; Electrocoagulation; Female; Fencloni

1979
Role of brain amines in the fetal hyperpyrexia caused by tranylcypromine in LiCl-pretreated rats.
    Japanese journal of pharmacology, 1979, Volume: 29, Issue:2

    Topics: Amines; Animals; Body Temperature; Brain Chemistry; Chlorpromazine; Cyproheptadine; Dopamine; Fenclo

1979
Endotoxin fever in the newborn kitten. The role of prostaglandins and monoamines.
    Acta physiologica Academiae Scientiarum Hungaricae, 1979, Volume: 54, Issue:3

    Topics: Animals; Body Temperature; Cats; Endotoxins; Escherichia coli; Fenclonine; Fever; Indomethacin; Nore

1979
Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice.
    Journal of neural transmission. General section, 1990, Volume: 82, Issue:3

    Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Body

1990
Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan.
    Journal of neurochemistry, 1971, Volume: 18, Issue:6

    Topics: 5-Hydroxytryptophan; Amines; Amino Acids; Animals; Brain Chemistry; Carboxy-Lyases; Dopamine; Fenclo

1971
Role of brain monoamines in the fatal hyperthermia induced by pethidine or imipramine in rabbits pretreated with pargyline.
    British journal of pharmacology, 1971, Volume: 42, Issue:4

    Topics: Animals; Brain; Brain Chemistry; Catecholamines; Fenclonine; Fever; Imipramine; Injections, Intraven

1971
Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat.
    British journal of pharmacology, 1971, Volume: 43, Issue:1

    Topics: Animals; Body Temperature; Drug Synergism; Fenclonine; Fever; Hypothalamus; Hypothermia; Injections,

1971
The role of brain serotonin in DDT-induced hyperpyrexia.
    Journal of neurochemistry, 1972, Volume: 19, Issue:4

    Topics: Animals; Brain; Brain Stem; DDT; Fenclonine; Fever; Fluorine; Hydroxyindoleacetic Acid; Male; Pargyl

1972
Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor.
    British journal of pharmacology, 1971, Volume: 43, Issue:4

    Topics: Animals; Brain; Chlorpromazine; Drug Synergism; Fenclonine; Fever; Humans; Hyperkinesis; Male; Monoa

1971
On the mechanism of fever caused by the mucopeptide of group A streptococcus.
    Naunyn-Schmiedeberg's archives of pharmacology, 1972, Volume: 274, Issue:2

    Topics: Animals; Bacterial Proteins; Brain; Disease Models, Animal; Fenclonine; Fever; Injections, Intraveno

1972
Hyperthermic response to intraventricular injection of scorpion venom: role of brain monoamines.
    Toxicon : official journal of the International Society on Toxinology, 1973, Volume: 11, Issue:4

    Topics: Amines; Animals; Antivenins; Brain; Diethylcarbamazine; Drug Synergism; Female; Fenclonine; Fever; H

1973
[5-Hydroxytryptamine and physiopathology of pain; on a polyalgic syndrome in the course of therapy with para-chlorophenylalanine].
    La Clinica terapeutica, 1972, Jun-30, Volume: 61, Issue:6

    Topics: Catecholamines; Eosinophilia; Fenclonine; Fever; Headache; Humans; Migraine Disorders; Pain; Seroton

1972
Proceedings: The effect of parachlorophenylalanine on the response of the conscious cat to intravenous and intraventricular bacterial pyrogen and to intraventricular prostaglandin E1.
    The Journal of physiology, 1974, Volume: 236, Issue:1

    Topics: Animals; Antibodies, Bacterial; Body Temperature; Cats; Fenclonine; Fever; Prostaglandin Antagonists

1974
Effects of p-chlorophenylalanine, alpha-methyl-p-tyrosine, morphine and chlorpromazine on prostaglandin E1 hyperthermia in the rabbit.
    Prostaglandins, 1974, Oct-25, Volume: 8, Issue:2

    Topics: Animals; Chlorpromazine; Female; Fenclonine; Fever; Male; Methyltyrosines; Morphine; Prostaglandin A

1974