fenclonine has been researched along with Epilepsy in 6 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats." | 7.69 | Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. ( Cheong, JH; Dailey, JW; Jobe, PC; Ko, KH; Yan, QS, 1994) |
| " Using the kainic acid model of epilepsy in rats, we tested the effects of serotonin depletion on (1) susceptibility to acute seizures, (2) development of spontaneous recurrent seizures and (3) behavioral and neuroanatomical sequelae of kainic acid treatment." | 3.85 | Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy. ( Brazete, CS; Lukoyanov, NV; Luz, LL; Maia, GH; Soares, JI, 2017) |
| "This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats." | 3.69 | Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. ( Cheong, JH; Dailey, JW; Jobe, PC; Ko, KH; Yan, QS, 1994) |
| "Correlation between the kindled seizure susceptibility and brain monoamine levels was investigated in the hippocampal and amygdaloid kindled cats." | 1.26 | [Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation]. ( Mitsunobu, K; Nakashima, T; Otsuki, S; Sato, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maia, GH | 1 |
| Brazete, CS | 1 |
| Soares, JI | 1 |
| Luz, LL | 1 |
| Lukoyanov, NV | 1 |
| Yan, QS | 1 |
| Jobe, PC | 1 |
| Cheong, JH | 1 |
| Ko, KH | 1 |
| Dailey, JW | 1 |
| Greer, CA | 1 |
| Alpern, HP | 1 |
| Sato, M | 1 |
| Nakashima, T | 1 |
| Mitsunobu, K | 1 |
| Otsuki, S | 1 |
| Neuman, RS | 1 |
| Wada, JA | 1 |
| Balzamo, E | 1 |
| Meldrum, BS | 1 |
| Naquet, R | 1 |
6 other studies available for fenclonine and Epilepsy
| Article | Year |
|---|---|
Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; Fenclonine; Hippocampus; Kainic A | 2017 |
Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Epilepsy; Female; Fenclonine; Fluoxetine; Hydroxyindo | 1994 |
Differential neurohumoral modulation of myoclonic and clonic seizures.
Topics: Aminooxyacetic Acid; Animals; Bicuculline; Dopamine; Epilepsies, Myoclonic; Epilepsy; Fenclonine; ga | 1978 |
[Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation].
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain Chemistry; Catecholamines; Cats; Dopamine; Electric St | 1976 |
Suppression of penicillin-induced epileptiform activity by noxious stimulation: mediation by 5-hydroxytryptamine.
Topics: 5-Hydroxytryptophan; Animals; Cerebral Cortex; Epilepsy; Fenclonine; Locus Coeruleus; Male; Membrane | 1986 |
Behavioural and electrographic effects of L-5-hydroxytryptophan and D, L-parachlorophenyl-alanine on epileptic Senegalese baboon (Papio papio).
Topics: 5-Hydroxytryptophan; Animals; Brain; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Fenc | 1972 |