Page last updated: 2024-11-02

fenclonine and Epilepsy

fenclonine has been researched along with Epilepsy in 6 studies

Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats."7.69Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. ( Cheong, JH; Dailey, JW; Jobe, PC; Ko, KH; Yan, QS, 1994)
" Using the kainic acid model of epilepsy in rats, we tested the effects of serotonin depletion on (1) susceptibility to acute seizures, (2) development of spontaneous recurrent seizures and (3) behavioral and neuroanatomical sequelae of kainic acid treatment."3.85Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy. ( Brazete, CS; Lukoyanov, NV; Luz, LL; Maia, GH; Soares, JI, 2017)
"This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats."3.69Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. ( Cheong, JH; Dailey, JW; Jobe, PC; Ko, KH; Yan, QS, 1994)
"Correlation between the kindled seizure susceptibility and brain monoamine levels was investigated in the hippocampal and amygdaloid kindled cats."1.26[Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation]. ( Mitsunobu, K; Nakashima, T; Otsuki, S; Sato, M, 1976)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maia, GH1
Brazete, CS1
Soares, JI1
Luz, LL1
Lukoyanov, NV1
Yan, QS1
Jobe, PC1
Cheong, JH1
Ko, KH1
Dailey, JW1
Greer, CA1
Alpern, HP1
Sato, M1
Nakashima, T1
Mitsunobu, K1
Otsuki, S1
Neuman, RS1
Wada, JA1
Balzamo, E1
Meldrum, BS1
Naquet, R1

Other Studies

6 other studies available for fenclonine and Epilepsy

ArticleYear
Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy.
    Brain research bulletin, 2017, Volume: 134

    Topics: Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; Fenclonine; Hippocampus; Kainic A

2017
Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1994, Volume: 350, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Epilepsy; Female; Fenclonine; Fluoxetine; Hydroxyindo

1994
Differential neurohumoral modulation of myoclonic and clonic seizures.
    Archives internationales de pharmacodynamie et de therapie, 1978, Volume: 236, Issue:1

    Topics: Aminooxyacetic Acid; Animals; Bicuculline; Dopamine; Epilepsies, Myoclonic; Epilepsy; Fenclonine; ga

1978
[Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation].
    No to shinkei = Brain and nerve, 1976, Volume: 28, Issue:5

    Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain Chemistry; Catecholamines; Cats; Dopamine; Electric St

1976
Suppression of penicillin-induced epileptiform activity by noxious stimulation: mediation by 5-hydroxytryptamine.
    Electroencephalography and clinical neurophysiology, 1986, Volume: 64, Issue:6

    Topics: 5-Hydroxytryptophan; Animals; Cerebral Cortex; Epilepsy; Fenclonine; Locus Coeruleus; Male; Membrane

1986
Behavioural and electrographic effects of L-5-hydroxytryptophan and D, L-parachlorophenyl-alanine on epileptic Senegalese baboon (Papio papio).
    Electroencephalography and clinical neurophysiology, 1972, Volume: 33, Issue:5

    Topics: 5-Hydroxytryptophan; Animals; Brain; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Fenc

1972