fenclonine has been researched along with Drug Withdrawal Symptoms in 18 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of different manipulations of brain serotonin (5-HT) content on the development of morphine dependence were investigated in rats, which were implanted with morphine pellets for 40 days." | 7.65 | Central serotonergic mechanisms and development of morphine dependence. ( Blasig, J; Gramsch, C; Herz, A; Papeschi, R, 1976) |
| "The effects of different manipulations of brain serotonin (5-HT) content on the development of morphine dependence were investigated in rats, which were implanted with morphine pellets for 40 days." | 3.65 | Central serotonergic mechanisms and development of morphine dependence. ( Blasig, J; Gramsch, C; Herz, A; Papeschi, R, 1976) |
| " 5-HTP alone (200 mg/kg) increased wet dog shakes epissodes, whereas TP alone in the same dosage practically did not have any influence on the wet dog shakes in morphine-dependent rats." | 1.27 | The role of central serotoninergic neurotransmission in the morphine abstinence syndrome in rats. ( Kruszewska, A; Langwiński, R, 1983) |
| " Rats were made dependent on diazepam by the chronic administration of this drug in the diet." | 1.26 | Effect of p-chlorophenylalanine on diazepam withdrawal signs in rats. ( Fukumori, R; Kitagawa, H; Satoh, T; Suzuki, T; Yanaura, S; Yoshii, T, 1980) |
| " In two separate studies it was demonstrated that p-CPA, in a dosage regimen that produces extensive depletion of brain serotonin (5-HT), accelerated tolerance loss." | 1.26 | Effect of p-chlorophenylalnine on the loss and maintenance of tolerance to ethanol. ( Frankel, D; Kalant, H; Khanna, JM; Leblanc, AE, 1978) |
| "After chronic administration of ethanol to mice by the intragastric route head twitches occur as part of the ethanol withdrawal syndrome." | 1.25 | Biogenic amines and head twitches in mice during ethanol withdrawal. ( Collier, HO; Hammond, MD; Schneider, C, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (94.44) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Suzuki, T | 2 |
| Fukumori, R | 2 |
| Yoshii, T | 2 |
| Yanaura, S | 3 |
| Satoh, T | 2 |
| Kitagawa, H | 2 |
| Tagashira, E | 1 |
| Hiramori, T | 1 |
| Urano, T | 1 |
| Kruszewska, A | 1 |
| Langwiński, R | 1 |
| Akaoka, H | 1 |
| Aston-Jones, G | 1 |
| Blasig, J | 1 |
| Papeschi, R | 1 |
| Gramsch, C | 1 |
| Herz, A | 1 |
| Frankel, D | 1 |
| Khanna, JM | 1 |
| Kalant, H | 1 |
| Leblanc, AE | 1 |
| Bramwell, GJ | 1 |
| Bradley, PB | 1 |
| Goldstein, DB | 1 |
| Maruyama, Y | 1 |
| Hayashi, G | 1 |
| Smits, SE | 1 |
| Takemori, AE | 1 |
| Algeri, S | 1 |
| Costa, E | 1 |
| Marshall, I | 1 |
| Grahame-Smith, DG | 1 |
| Collier, HO | 3 |
| Francis, DL | 1 |
| Schneider, C | 2 |
| Ho, IK | 1 |
| Lu, SE | 1 |
| Stolman, S | 1 |
| Loh, HH | 1 |
| Way, EL | 1 |
| Pozuelo, J | 1 |
| Kerr, FW | 1 |
| Griffiths, PM | 1 |
| Littleton, JM | 1 |
| Ortiz, A | 1 |
| Hammond, MD | 1 |
1 review available for fenclonine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Drug dependence: a pharmacological analysis.
Topics: Acetylcholine; Animals; Atropine; Brain Chemistry; Catecholamines; Cerebral Cortex; Chemoreceptor Ce | 1972 |
1 trial available for fenclonine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Studies on the relationship between 5-hydroxytryptamine turnover in brain and tolerance and physical dependence in mice.
Topics: Animals; Aspirin; Brain; Cyclazocine; Drug Tolerance; Fenclonine; Humans; Levorphanol; Male; Methado | 1971 |
16 other studies available for fenclonine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Effect of p-chlorophenylalanine on diazepam withdrawal signs in rats.
Topics: Animals; Body Weight; Brain Chemistry; Diazepam; Drug Synergism; Eating; Fenclonine; Humans; Hydroxy | 1980 |
Formation of physical dependence on barbiturates and cerebral monoamines.
Topics: alpha-Methyltyrosine; Animals; Barbital; Barbiturates; Biogenic Amines; Body Weight; Brain; Catechol | 1983 |
The role of central serotoninergic neurotransmission in the morphine abstinence syndrome in rats.
Topics: 5-Hydroxytryptophan; Animals; Brain; Fenclonine; Humans; Male; Metergoline; Morphine; Rats; Rats, In | 1983 |
Effect of parachlorophenylalanine on the incidence of abnormal behaviors observed following diazepam withdrawal.
Topics: Animals; Behavior, Animal; Diazepam; Fenclonine; Humans; Male; Rats; Rats, Inbred Strains; Substance | 1981 |
Indirect serotonergic agonists attenuate neuronal opiate withdrawal.
Topics: 1-Naphthylamine; Animals; Fenclonine; Fenfluramine; Kynurenine; Locus Coeruleus; Morphine Dependence | 1993 |
Central serotonergic mechanisms and development of morphine dependence.
Topics: 5,6-Dihydroxytryptamine; Animals; Brain Chemistry; Cyproheptadine; Fenclonine; Humans; Injections, I | 1976 |
Effect of p-chlorophenylalnine on the loss and maintenance of tolerance to ethanol.
Topics: Animals; Drug Interactions; Drug Tolerance; Ethanol; Fenclonine; Humans; Male; Rats; Substance Withd | 1978 |
Effects of morphine on brainstem neurones in naive and chronic morphine-treated rats, and effects of PCPA.
Topics: Animals; Brain Stem; Drinking; Eating; Fenclonine; Humans; Male; Morphine; Morphine Dependence; Moto | 1978 |
Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.
Topics: 5-Hydroxytryptophan; Acetates; Aminobutyrates; Animals; Atropine; Ethanol; Fenclonine; Humans; Male; | 1973 |
Physical dependence on morphine fails to increase serotonin turnover rate in rat brain.
Topics: Animals; Body Temperature; Brain; Carbon Isotopes; Fenclonine; Humans; Male; Mathematics; Morphine D | 1971 |
Evidence against a role of brain 5-hydroxytryptamine in the development of physical dependence upon morphine in mice.
Topics: Animals; Body Weight; Brain Chemistry; Drug Interactions; Female; Fenclonine; Humans; Kinetics; Mice | 1971 |
Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation.
Topics: Animals; Atropine; Behavior, Animal; Drug Interactions; Fenclonine; Heroin; Humans; Indomethacin; In | 1972 |
Influence of p-chlorophenylalanine on morphine tolerance and physical dependence and regional brain serotonin turnover studies in morphine tolerant-dependent mice.
Topics: Analgesia; Animals; Body Weight; Brain Chemistry; Brain Stem; Drug Tolerance; Fenclonine; Humans; Hy | 1972 |
Suppression of craving and other signs of dependence in morphine-addicted monkeys by administration of alpha-methyl-para-tyrosine.
Topics: Animals; Female; Fenclonine; Haloperidol; Haplorhini; Humans; Hypothalamus; Injections, Intravenous; | 1972 |
Effect of p-chlorophenylalanine on brain monoamines and behaviour during ethanol withdrawal in mice.
Topics: Amines; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Ethanol; Fenclonine; Humans; Male; Mic | 1974 |
Biogenic amines and head twitches in mice during ethanol withdrawal.
Topics: 5-Hydroxytryptophan; Amphetamine; Amphetamines; Animals; Behavior, Animal; Biogenic Amines; Cerebral | 1974 |