fenclonine has been researched along with Disorders of Excessive Somnolence in 1 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
| Excerpt | Relevance | Reference |
|---|---|---|
| "(4) the mechanisms of this hypersomnia are discussed in light of the biochemical results showing an increase of the biosynthesis of serotonin in the rostral raphe system." | 1.25 | [Hypersomnia by isthmic lesion in cat. II. Neurophysiological and pharmacological study]. ( Blondaux, C; Jouvet, M; Petitjean, F; Sakai, K, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petitjean, F | 1 |
| Sakai, K | 1 |
| Blondaux, C | 1 |
| Jouvet, M | 1 |
1 other study available for fenclonine and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
[Hypersomnia by isthmic lesion in cat. II. Neurophysiological and pharmacological study].
Topics: Animals; Cats; Disorders of Excessive Somnolence; Electroencephalography; Female; Fenclonine; Functi | 1975 |