fenclonine has been researched along with Diathesis in 2 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using the kainic acid model of epilepsy in rats, we tested the effects of serotonin depletion on (1) susceptibility to acute seizures, (2) development of spontaneous recurrent seizures and (3) behavioral and neuroanatomical sequelae of kainic acid treatment." | 3.85 | Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy. ( Brazete, CS; Lukoyanov, NV; Luz, LL; Maia, GH; Soares, JI, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maia, GH | 1 |
| Brazete, CS | 1 |
| Soares, JI | 1 |
| Luz, LL | 1 |
| Lukoyanov, NV | 1 |
| Katkov, IuA | 1 |
2 other studies available for fenclonine and Diathesis
| Article | Year |
|---|---|
Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; Fenclonine; Hippocampus; Kainic A | 2017 |
[Changes in the predisposition of rats to audiogenic seizures by intervention in monoamine metabolism].
Topics: Acoustic Stimulation; Animals; Brain; Disease Susceptibility; Ditiocarb; Dopamine; Fenclonine; Ipron | 1984 |