fenclonine has been researched along with Depression in 46 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively." | 7.71 | Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. ( Ong, YP; Wong, PT, 2001) |
| "Endogenously depressed patients who showed an antidepressant response to the tricyclic drug imipramine continued to show sustained well being after alpha-MPT was added whereas depression returned when small doses of PCPA were added for brief periods." | 5.04 | Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients. ( Friedman, E; Gershon, S; Goldstein, M; Shopsin, B; Wilk, S, 1975) |
| "We investigated whether tipepidine exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone (ACTH)-treated rats, which is known as a treatment-resistant depression model, and we studied the pharmacological mechanisms of the effects of tipepidine." | 3.83 | Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. ( Honda, S; Kawaura, K; Ogata, Y; Shirasaki, T; Soeda, F; Takahama, K, 2016) |
| "This study investigates the effect of the petroleum ether, chloroform, and ethyl acetate fractions of the total ethanolic extract of Convolvulus pluricaulis Choisy (Family: Convolvulaceae) on depression in mice." | 3.74 | Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests. ( Dhingra, D; Valecha, R, 2007) |
| "Clinical studies have shown that folic acid plays a role in the pathophysiology of depression." | 3.74 | Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. ( Brocardo, PS; Budni, J; Kaster, MP; Rodrigues, AL; Santos, AR, 2008) |
| " However, single treatment with XBXT-2 had no effect on yohimbine toxicity and high dose of apomorphine-induced hypothermia in mice." | 3.74 | Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang. ( An, L; Li, YF; Liu, XM; Yu, NJ; Yuan, L; Zhang, YZ; Zhao, N, 2008) |
| "The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials." | 3.71 | The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors. ( Belmaker, RH; Bourin, M; Clenet, F; Einat, H; Shaldubina, A, 2001) |
| "The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively." | 3.71 | Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. ( Ong, YP; Wong, PT, 2001) |
| "Caffeine-treated adolescent male rats were exposed to caffeine (0." | 1.56 | Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat. ( Abdulzahir, A; Hwang, K; Sanford, J; Turgeon, SM, 2020) |
| "Carvacrol (cvc) was administered orally at single doses of 12." | 1.37 | Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic system. ( de Sousa, DP; de Sousa, FC; de Vasconcelos, SM; Fonteles, MM; Macedo, DS; Melo, FH; Moura, BA; Viana, GS, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (23.91) | 18.7374 |
| 1990's | 2 (4.35) | 18.2507 |
| 2000's | 16 (34.78) | 29.6817 |
| 2010's | 16 (34.78) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Turgeon, SM | 1 |
| Abdulzahir, A | 1 |
| Hwang, K | 1 |
| Sanford, J | 1 |
| Siddiqui, PJA | 1 |
| Khan, A | 1 |
| Uddin, N | 1 |
| Khaliq, S | 1 |
| Rasheed, M | 1 |
| Nawaz, S | 1 |
| Hanif, M | 1 |
| Dar, A | 1 |
| Amoateng, P | 1 |
| Kukuia, KKE | 1 |
| Mensah, JA | 1 |
| Osei-Safo, D | 1 |
| Adjei, S | 1 |
| Eklemet, AA | 1 |
| Vinyo, EA | 1 |
| Karikari, TK | 1 |
| Silva, EF | 1 |
| Silva, AI | 1 |
| Asth, L | 1 |
| Souza, LS | 1 |
| Zaveri, NT | 1 |
| Guerrini, R | 1 |
| Calo', G | 1 |
| Ruzza, C | 1 |
| Gavioli, EC | 1 |
| Saleem, AM | 1 |
| Taufik Hidayat, M | 1 |
| Jais, AM | 1 |
| Fakurazi, S | 1 |
| Moklas, MA | 1 |
| Sulaiman, MR | 1 |
| Amom, Z | 1 |
| Basir, R | 1 |
| Limón-Morales, O | 1 |
| Soria-Fregozo, C | 1 |
| Arteaga-Silva, M | 1 |
| Vázquez-Palacios, G | 1 |
| Bonilla-Jaime, H | 1 |
| Udo, H | 1 |
| Hamasu, K | 1 |
| Furuse, M | 1 |
| Sugiyama, H | 1 |
| Das, SK | 1 |
| Barhwal, K | 1 |
| Hota, SK | 1 |
| Thakur, MK | 1 |
| Srivastava, RB | 1 |
| Fukumoto, K | 1 |
| Iijima, M | 1 |
| Chaki, S | 1 |
| Kawaura, K | 1 |
| Ogata, Y | 1 |
| Honda, S | 1 |
| Soeda, F | 1 |
| Shirasaki, T | 1 |
| Takahama, K | 1 |
| Boyce-Rustay, JM | 1 |
| Palachick, B | 1 |
| Hefner, K | 1 |
| Chen, YC | 1 |
| Karlsson, RM | 1 |
| Millstein, RA | 1 |
| Harvey-White, J | 1 |
| Holmes, A | 1 |
| Jiang, XZ | 1 |
| Li, YF | 2 |
| Zhang, YZ | 2 |
| Chen, HX | 1 |
| Li, J | 1 |
| Wang, NP | 1 |
| Zhao, Z | 1 |
| Zhang, HT | 1 |
| Bootzin, E | 1 |
| Millan, MJ | 1 |
| O'Donnell, JM | 1 |
| Licht, CL | 1 |
| Marcussen, AB | 1 |
| Wegener, G | 2 |
| Overstreet, DH | 1 |
| Aznar, S | 1 |
| Knudsen, GM | 1 |
| Kwon, S | 1 |
| Lee, B | 1 |
| Kim, M | 1 |
| Lee, H | 1 |
| Park, HJ | 1 |
| Hahm, DH | 1 |
| Xu, Y | 1 |
| Wang, Z | 1 |
| You, W | 1 |
| Zhang, X | 1 |
| Li, S | 1 |
| Barish, PA | 1 |
| Vernon, MM | 1 |
| Du, X | 1 |
| Li, G | 1 |
| Pan, J | 1 |
| Ogle, WO | 1 |
| Yi, LT | 1 |
| Li, CF | 1 |
| Zhan, X | 1 |
| Cui, CC | 1 |
| Xiao, F | 1 |
| Zhou, LP | 1 |
| Xie, Y | 1 |
| Melo, FH | 1 |
| Moura, BA | 1 |
| de Sousa, DP | 1 |
| de Vasconcelos, SM | 1 |
| Macedo, DS | 1 |
| Fonteles, MM | 1 |
| Viana, GS | 1 |
| de Sousa, FC | 1 |
| Vines, A | 1 |
| Delattre, AM | 1 |
| Lima, MM | 1 |
| Rodrigues, LS | 1 |
| Suchecki, D | 1 |
| Machado, RB | 1 |
| Tufik, S | 1 |
| Pereira, SI | 1 |
| Zanata, SM | 1 |
| Ferraz, AC | 1 |
| Manna, SS | 1 |
| Umathe, SN | 1 |
| Kuo, JR | 1 |
| Cheng, YH | 1 |
| Chen, YS | 1 |
| Chio, CC | 1 |
| Gean, PW | 1 |
| Dias Elpo Zomkowski, A | 1 |
| Oscar Rosa, A | 1 |
| Lin, J | 1 |
| Santos, AR | 2 |
| Calixto, JB | 1 |
| Lúcia Severo Rodrigues, A | 1 |
| Jones, MD | 1 |
| Lucki, I | 1 |
| Savegnago, L | 1 |
| Jesse, CR | 1 |
| Pinto, LG | 1 |
| Rocha, JB | 1 |
| Nogueira, CW | 1 |
| Zeni, G | 1 |
| Dhingra, D | 1 |
| Valecha, R | 1 |
| Dos Santos, JG | 1 |
| Kawano, F | 1 |
| Nishida, MM | 1 |
| Yamamura, Y | 1 |
| Mello, LE | 1 |
| Tabosa, A | 1 |
| Brocardo, PS | 1 |
| Budni, J | 1 |
| Kaster, MP | 1 |
| Rodrigues, AL | 1 |
| Krass, M | 1 |
| Vasar, E | 1 |
| Volke, V | 1 |
| Christianson, JP | 1 |
| Rabbett, S | 1 |
| Lyckland, J | 1 |
| Drugan, RC | 1 |
| An, L | 1 |
| Yu, NJ | 1 |
| Liu, XM | 1 |
| Zhao, N | 1 |
| Yuan, L | 1 |
| Nakatomi, Y | 1 |
| Yokoyama, C | 1 |
| Kinoshita, S | 1 |
| Masaki, D | 1 |
| Tsuchida, H | 1 |
| Onoe, H | 1 |
| Yoshimoto, K | 1 |
| Fukui, K | 1 |
| Eriksson, E | 1 |
| Modigh, K | 1 |
| Matsuda, T | 1 |
| Somboonthum, P | 1 |
| Suzuki, M | 1 |
| Asano, S | 1 |
| Baba, A | 1 |
| Einat, H | 1 |
| Clenet, F | 1 |
| Shaldubina, A | 1 |
| Belmaker, RH | 1 |
| Bourin, M | 1 |
| Wong, PT | 1 |
| Ong, YP | 1 |
| Carlsson, A | 1 |
| Benkert, O | 1 |
| Shopsin, B | 2 |
| Gershon, S | 2 |
| Goldstein, M | 1 |
| Friedman, E | 1 |
| Wilk, S | 2 |
| Luchins, D | 1 |
| Tachiki, KH | 1 |
| Takagi, A | 1 |
| Tateishi, T | 1 |
| Kido, A | 1 |
| Nishiwaki, K | 1 |
| Nakamura, E | 1 |
| Nagayama, H | 1 |
| Takahashi, R | 1 |
| Cervo, L | 1 |
| Samanin, R | 1 |
| Van Woert, MH | 1 |
| Ambani, LM | 1 |
| Levine, RJ | 1 |
| Mendels, J | 1 |
| Frazer, A | 1 |
| Goodwin, FK | 2 |
| Post, RM | 2 |
3 reviews available for fenclonine and Depression
| Article | Year |
|---|---|
Depression, alpha 2-receptors and sex hormones: neuroendocrine studies in rat.
Topics: Animals; Antidepressive Agents; Apomorphine; Carbidopa; Castration; Clonidine; Depression; Dihydrote | 1984 |
The contribution of drug research to investigating the nature of endogenous depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Female; Fenclonine; Histamine H1 Antag | 1976 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
5 trials available for fenclonine and Depression
| Article | Year |
|---|---|
Studies on pituitary hormones and releasing hormones in depression and sexual impotence.
Topics: 5-Hydroxytryptophan; Benserazide; Bipolar Disorder; Clinical Trials as Topic; Depression; Erectile D | 1975 |
Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients.
Topics: 3-Methoxy-4-hydroxyphenylethanol; Adult; Antimetabolites; Biogenic Amines; Clinical Trials as Topic; | 1975 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
Clinical effects of para-chlorophenylalanine in Parkinson's disease.
Topics: Aged; Benztropine; Brain; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; Evaluation S | 1972 |
Estimation of brain amine metabolism in affective illness: cerebrospinal fluid studies utilizing probenecid.
Topics: Bipolar Disorder; Brain; Depression; Dihydroxyphenylalanine; Fenclonine; Homovanillic Acid; Humans; | 1974 |
39 other studies available for fenclonine and Depression
| Article | Year |
|---|---|
Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat.
Topics: Age Factors; alpha-Methyltyrosine; Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behav | 2020 |
Antidepressant-like deliverables from the sea: evidence on the efficacy of three different brown seaweeds via involvement of monoaminergic system.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Depression; Dopamine Antagonis | 2017 |
An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms.
Topics: Animals; Antidepressive Agents; Asteraceae; Behavior, Animal; Depression; Disease Models, Animal; Fe | 2018 |
Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test.
Topics: Aggression; Agonistic Behavior; Animals; Anxiety; Bipolar Disorder; Carbamazepine; Cycloheptanes; De | 2019 |
Involvement of monoaminergic system in the antidepressant-like effect of aqueous extract of Channa striatus in mice.
Topics: Adrenergic Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonist | 2013 |
Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Body Temperature; Clomipra | 2014 |
VEGF-induced antidepressant effects involve modulation of norepinephrine and serotonin systems.
Topics: alpha-Methyltyrosine; Animals; Brain; Depression; Disease Models, Animal; Enzyme Inhibitors; Fenclon | 2014 |
Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats.
Topics: Animals; Anxiety; Cyclic AMP Response Element-Binding Protein; Dendrites; Depression; Fenclonine; Hi | 2015 |
The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN.
Topics: Amino Acids; Animals; Antidepressive Agents; Depression; Dorsal Raphe Nucleus; Fenclonine; Ketamine; | 2016 |
Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Benzazepines; Depression; Disease Model | 2016 |
Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Body Temp | 2008 |
[5-HT1A/1B receptors, alpha2-adrenoceptors and the post-receptor adenylate cyclase activation in the mice brain are involved in the antidepressant-like action of agmatine].
Topics: Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Agmatine; Animals; Ant | 2008 |
Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Cyclohex | 2009 |
The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Brain; Citalopram; Depression; D | 2009 |
Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test.
Topics: alpha-Methyltyrosine; Analysis of Variance; Animals; Antidepressive Agents; Bupleurum; Depression; D | 2010 |
Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system.
Topics: Animals; Antidepressive Agents; Antioxidants; Apomorphine; Behavior, Animal; Brain Chemistry; Depres | 2010 |
Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Depress | 2010 |
Antidepressant-like effect of carvacrol (5-Isopropyl-2-methylphenol) in mice: involvement of dopaminergic system.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepre | 2011 |
The role of 5-HT₁A receptors in fish oil-mediated increased BDNF expression in the rat hippocampus and cortex: a possible antidepressant mechanism.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Depression; Disea | 2012 |
A possible participation of transient receptor potential vanilloid type 1 channels in the antidepressant effect of fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Capsaicin; Depression; Disease Models, Animal; Do | 2012 |
Involvement of extracellular signal regulated kinases in traumatic brain injury-induced depression in rodents.
Topics: Animals; Anxiety; Blotting, Western; Brain Injuries; Coloring Agents; Depression; Extracellular Sign | 2013 |
Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diseas | 2004 |
Sex differences in the regulation of serotonergic transmission and behavior in 5-HT receptor knockout mice.
Topics: Animals; Behavior, Animal; Brain; Depression; Extracellular Space; Female; Fenclonine; Fluoxetine; H | 2005 |
Monoaminergic agents modulate antidepressant-like effect caused by diphenyl diselenide in rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzen | 2007 |
Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests.
Topics: Acetates; Alkanes; Animals; Antidepressive Agents; Chloroform; Convolvulus; Depression; Fenclonine; | 2007 |
Antidepressive-like effects of electroacupuncture in rats.
Topics: Analysis of Variance; Animals; Depression; Disease Models, Animal; Electroacupuncture; Fenclonine; H | 2008 |
Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Depression; Female; Fenclonine; Fluoxe | 2008 |
Antidepressant-like effect of agmatine is not mediated by serotonin.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diseas | 2008 |
The immobility produced by intermittent swim stress is not mediated by serotonin.
Topics: Animals; Body Temperature; Corticosterone; Depression; Fenclonine; Immobilization; Male; Rats; Rats, | 2008 |
Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang.
Topics: Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Depression; Disease Models, Animal; D | 2008 |
Serotonergic mediation of the antidepressant-like effect of the green leaves odor in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Citalopram; Depression; Disease M | 2008 |
Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Dep | 1995 |
The antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors.
Topics: Animals; Antidepressive Agents; Benzylamines; Depression; Disease Models, Animal; Drug Interactions; | 2001 |
Acute antidepressant-like and antianxiety-like effects of tryptophan in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Dose-Res | 2001 |
Exploration of affective illness.
Topics: Adult; Bipolar Disorder; Brain; Depression; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 1976 |
Animal model of depression. III. Mechanism of action of tetrabenazine.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Depression; Disease Models, Animal; Dopamine; | 1978 |
Effect of chronic treatment with 8-OH-DPAT in the forced swimming test requires the integrity of presynaptic serotonergic mechanisms.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Conditioning, Operant; Dep | 1991 |
Brain biogenic amine depletion and mood.
Topics: Affective Symptoms; Amines; Behavior; Brain; Catecholamines; Depression; Epinephrine; Fenclonine; Hu | 1974 |
Brain serotonin, affective illness, and antidepressant drugs: cerebrospinal fluid studies with probenecid.
Topics: Affective Symptoms; Amitriptyline; Antidepressive Agents; Brain; Brain Chemistry; Depression; Fenclo | 1974 |