fenclonine has been researched along with Colitis in 2 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
Excerpt | Relevance | Reference |
---|---|---|
"In vivo 5-HT release and regional hypothalamic 5-HT and tryptophan concentrations were measured in rats with 2,4,6,-trinitrobenzene sulfonic acid (TNBS)-induced colitis, healthy controls, and animals pair-fed to match the food intake of the colitic group." | 3.70 | The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis. ( Ballinger, A; Dryden, S; El-Haj, T; Farthing, MJ; Obeid, O; Perrett, D; Turvill, J; Williams, G, 2000) |
"Colitis was induced with dextran sulfate sodium or dinitrobenzene sulfonic acid in tryptophan hydroxylase 1-deficient (TPH1(-/-)) mice, which have markedly reduced 5-HT in the gastrointestinal tract, and in mice given the 5-HT synthesis inhibitor parachlorophenylalanine." | 1.35 | Serotonin has a key role in pathogenesis of experimental colitis. ( Collins, M; Côté, F; Deng, Y; El-Sharkawy, RT; Ghia, JE; Khan, WI; Li, N; Mallet, J; Wang, H, 2009) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Ghia, JE | 1 |
Li, N | 1 |
Wang, H | 1 |
Collins, M | 1 |
Deng, Y | 1 |
El-Sharkawy, RT | 1 |
Côté, F | 1 |
Mallet, J | 1 |
Khan, WI | 1 |
Ballinger, A | 1 |
El-Haj, T | 1 |
Perrett, D | 1 |
Turvill, J | 1 |
Obeid, O | 1 |
Dryden, S | 1 |
Williams, G | 1 |
Farthing, MJ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Investigating Serotonin Signalling in IBD Patients[NCT01650311] | 60 participants (Anticipated) | Observational | 2012-07-31 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 other studies available for fenclonine and Colitis
Article | Year |
---|---|
Serotonin has a key role in pathogenesis of experimental colitis.
Topics: Animals; Benzenesulfonates; C-Reactive Protein; Colitis; Dextran Sulfate; Fenclonine; Interleukin-1b | 2009 |
The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis.
Topics: Amino Acids; Animals; Anorexia; Colitis; Drinking; Eating; Fenclonine; Hydroxyindoleacetic Acid; Hyp | 2000 |