Page last updated: 2024-11-02

fenclonine and Colitis

fenclonine has been researched along with Colitis in 2 studies

Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.

Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.

Research Excerpts

ExcerptRelevanceReference
"In vivo 5-HT release and regional hypothalamic 5-HT and tryptophan concentrations were measured in rats with 2,4,6,-trinitrobenzene sulfonic acid (TNBS)-induced colitis, healthy controls, and animals pair-fed to match the food intake of the colitic group."3.70The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis. ( Ballinger, A; Dryden, S; El-Haj, T; Farthing, MJ; Obeid, O; Perrett, D; Turvill, J; Williams, G, 2000)
"Colitis was induced with dextran sulfate sodium or dinitrobenzene sulfonic acid in tryptophan hydroxylase 1-deficient (TPH1(-/-)) mice, which have markedly reduced 5-HT in the gastrointestinal tract, and in mice given the 5-HT synthesis inhibitor parachlorophenylalanine."1.35Serotonin has a key role in pathogenesis of experimental colitis. ( Collins, M; Côté, F; Deng, Y; El-Sharkawy, RT; Ghia, JE; Khan, WI; Li, N; Mallet, J; Wang, H, 2009)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ghia, JE1
Li, N1
Wang, H1
Collins, M1
Deng, Y1
El-Sharkawy, RT1
Côté, F1
Mallet, J1
Khan, WI1
Ballinger, A1
El-Haj, T1
Perrett, D1
Turvill, J1
Obeid, O1
Dryden, S1
Williams, G1
Farthing, MJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Investigating Serotonin Signalling in IBD Patients[NCT01650311]60 participants (Anticipated)Observational2012-07-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

2 other studies available for fenclonine and Colitis

ArticleYear
Serotonin has a key role in pathogenesis of experimental colitis.
    Gastroenterology, 2009, Volume: 137, Issue:5

    Topics: Animals; Benzenesulfonates; C-Reactive Protein; Colitis; Dextran Sulfate; Fenclonine; Interleukin-1b

2009
The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis.
    Gastroenterology, 2000, Volume: 118, Issue:3

    Topics: Amino Acids; Animals; Anorexia; Colitis; Drinking; Eating; Fenclonine; Hydroxyindoleacetic Acid; Hyp

2000