fenclonine has been researched along with Colitis in 2 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In vivo 5-HT release and regional hypothalamic 5-HT and tryptophan concentrations were measured in rats with 2,4,6,-trinitrobenzene sulfonic acid (TNBS)-induced colitis, healthy controls, and animals pair-fed to match the food intake of the colitic group." | 3.70 | The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis. ( Ballinger, A; Dryden, S; El-Haj, T; Farthing, MJ; Obeid, O; Perrett, D; Turvill, J; Williams, G, 2000) |
| "Colitis was induced with dextran sulfate sodium or dinitrobenzene sulfonic acid in tryptophan hydroxylase 1-deficient (TPH1(-/-)) mice, which have markedly reduced 5-HT in the gastrointestinal tract, and in mice given the 5-HT synthesis inhibitor parachlorophenylalanine." | 1.35 | Serotonin has a key role in pathogenesis of experimental colitis. ( Collins, M; Côté, F; Deng, Y; El-Sharkawy, RT; Ghia, JE; Khan, WI; Li, N; Mallet, J; Wang, H, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghia, JE | 1 |
| Li, N | 1 |
| Wang, H | 1 |
| Collins, M | 1 |
| Deng, Y | 1 |
| El-Sharkawy, RT | 1 |
| Côté, F | 1 |
| Mallet, J | 1 |
| Khan, WI | 1 |
| Ballinger, A | 1 |
| El-Haj, T | 1 |
| Perrett, D | 1 |
| Turvill, J | 1 |
| Obeid, O | 1 |
| Dryden, S | 1 |
| Williams, G | 1 |
| Farthing, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating Serotonin Signalling in IBD Patients[NCT01650311] | 60 participants (Anticipated) | Observational | 2012-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for fenclonine and Colitis
| Article | Year |
|---|---|
Serotonin has a key role in pathogenesis of experimental colitis.
Topics: Animals; Benzenesulfonates; C-Reactive Protein; Colitis; Dextran Sulfate; Fenclonine; Interleukin-1b | 2009 |
The role of medial hypothalamic serotonin in the suppression of feeding in a rat model of colitis.
Topics: Amino Acids; Animals; Anorexia; Colitis; Drinking; Eating; Fenclonine; Hydroxyindoleacetic Acid; Hyp | 2000 |