fenclonine has been researched along with Central Hypothyroidism in 8 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neonatal hypothyroidism is known to induce the accumulation of substance P and serotonin in many discrete brain nuclei of the rat." | 3.67 | The effects of p-chlorophenylalanine (PCPA) treatment on the substance P content measured in discrete brain nuclei of normal and neonatally-induced hypothyroid rats. ( Dupont, A; Mérand, Y; Savard, P, 1984) |
| "In both cases, prior induction of primary hypothyroidism interfered with the expected diabetes-induced reduction in 5-HT turnover." | 1.28 | Streptozotocin-induced decreases in serotonin turnover are prevented by thyroidectomy. ( Bellush, LL; Henley, WN, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Savard, P | 3 |
| Mérand, Y | 3 |
| Bédard, P | 1 |
| Dussault, JH | 1 |
| Dupont, A | 3 |
| Di Paolo, T | 1 |
| Walker, RF | 2 |
| Timiras, PS | 2 |
| Männistö, PT | 1 |
| Ranta, T | 1 |
| Henley, WN | 1 |
| Bellush, LL | 1 |
| Boiadzhieva, N | 1 |
8 other studies available for fenclonine and Central Hypothyroidism
| Article | Year |
|---|---|
Comparative effects of neonatal hypothyroidism and euthyroidism on TRH and substance P content of lumbar spinal cord in saline and PCPA-treated rats.
Topics: Animals; Fenclonine; Ganglia, Spinal; Hypothyroidism; Male; Neurons; Rats; Rats, Inbred Strains; Rec | 1983 |
The effects of p-chlorophenylalanine (PCPA) treatment on the substance P content measured in discrete brain nuclei of normal and neonatally-induced hypothyroid rats.
Topics: Animals; Animals, Newborn; Brain Chemistry; Fenclonine; Hypothyroidism; Rats; Rats, Inbred Strains; | 1984 |
Effect of neonatal hypothyroidism on the serotonin system of the rat brain.
Topics: Animals; Animals, Newborn; Brain Chemistry; Fenclonine; Hydroxyindoleacetic Acid; Hypothyroidism; Io | 1984 |
Loss of serotonin circadian rhythms in the pineal gland of androgenized female rats.
Topics: Aging; Animals; Circadian Rhythm; Estrus; Female; Fenclonine; Hypothyroidism; Luteinizing Hormone; P | 1980 |
Serotonin in development of cyclic reproductive function.
Topics: Animals; Circadian Rhythm; Dopamine; Estrogens; Female; Fenclonine; Hypothalamus; Hypothyroidism; Li | 1981 |
Neurotransmitter control of thyrotrophin secretion in hypothyroid rats.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Bromocriptine; Clonidine; Ditiocarb; Fenclonine; Hypothyr | 1978 |
Streptozotocin-induced decreases in serotonin turnover are prevented by thyroidectomy.
Topics: Animals; Corticosterone; Diabetes Mellitus, Experimental; Exploratory Behavior; Fenclonine; Hydroxyi | 1992 |
[Effect of serotoninergic agents on the thyrotropic function of the adenohypophysis].
Topics: 5-Hydroxytryptophan; Animals; Cold Temperature; Fenclonine; Hypothyroidism; Male; Methysergide; Pitu | 1987 |