fenclonine has been researched along with Carcinoma, Hepatocellular in 3 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenylalanine hydroxylase in Reuber H4 hepatoma cell cultures can be rapidly inactivated by the addition of epinephrine, norepinephrine, dopamine, or 3,4-dihydroxyphenylalanine, in order of decreasing effectiveness, to the culture medium." | 1.26 | Reversible inactivation of phenylalanine hydroxylase by catecholamines in cultured hepatoma cells. ( Miller, MR; Shiman, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, MR | 3 |
| Shiman, R | 3 |
| McClure, D | 2 |
3 other studies available for fenclonine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Reversible inactivation of phenylalanine hydroxylase by catecholamines in cultured hepatoma cells.
Topics: Carcinoma, Hepatocellular; Catecholamines; Cell Line; Dihydroxyphenylalanine; Dopamine; Epinephrine; | 1976 |
Mechanism of inactivation of phenylalanine hydroxylase by p-chlorophenylalanine in hepatome cells in culture. Two possible models.
Topics: Animals; Antigens; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Fenclonine; Isoenzymes; Kine | 1976 |
p-Chlorphenylalanine effect on phenylalanine hydroxylase in hepatoma cells in culture.
Topics: Animals; Carcinoma, Hepatocellular; Cells, Cultured; Fenclonine; Hydrocortisone; Kinetics; L-Lactate | 1975 |