fenclonine has been researched along with Cancer of Gastrointestinal Tract in 3 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| " PCPA (2 g 8 hourly for 2 or 3 days prior to cisplatin) reduced the spontaneous urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), inhibited the increase in urinary 5-HIAA induced by cisplatin and markedly attenuated the acute period of nausea and vomiting associated with the cytotoxic drug." | 5.08 | Treatment with para-chlorophenylalanine antagonises the emetic response and the serotonin-releasing actions of cisplatin in cancer patients. ( Alfieri, AB; Cubeddu, LX, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Modlin, IM | 1 |
| Spann, JL | 1 |
| Van Wormer, D | 1 |
| Sandlin, ME | 1 |
| Alfieri, AB | 1 |
| Cubeddu, LX | 1 |
1 trial available for fenclonine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Treatment with para-chlorophenylalanine antagonises the emetic response and the serotonin-releasing actions of cisplatin in cancer patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fenclonine; Gastrointestin | 1995 |
2 other studies available for fenclonine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Carcinoid syndrome.
Topics: Antineoplastic Agents; Apudoma; Carcinoid Tumor; Cyproheptadine; Fenclonine; Gastrointestinal Motili | 1980 |
Malignant carcinoid syndrome: two case reports.
Topics: Aged; Female; Fenclonine; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Malignant Carcinoid S | 1980 |