fenclonine has been researched along with Brain Ischemia in 2 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In rats with cerebral ischemia, a low dose (10 mg/kg, i." | 5.27 | Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1985) |
| "In rats with cerebral ischemia, idebenone (10 mg/kg, i." | 1.28 | Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1989) |
| "In rats with cerebral ischemia, a low dose (10 mg/kg, i." | 1.27 | Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia. ( Kakihana, M; Nagai, Y; Nagaoka, A; Nagawa, Y; Narumi, S; Yamazaki, N, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nagai, Y | 2 |
| Narumi, S | 2 |
| Kakihana, M | 2 |
| Yamazaki, N | 2 |
| Nagaoka, A | 2 |
| Nagawa, Y | 2 |
2 other studies available for fenclonine and Brain Ischemia
| Article | Year |
|---|---|
Effects of idebenone on metabolism of monoamines and cyclic AMP formation in rats.
Topics: Animals; Benzoquinones; Biogenic Monoamines; Brain; Brain Ischemia; Cyclic AMP; Disease Models, Anim | 1989 |
Effects of idebenone (CV-2619) on metabolism of monoamines, especially serotonin, in the brain of normal rats and rats with cerebral ischemia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzoquinones; Biogenic Amines; Brain; Brain Ischemia; Chro | 1985 |