fenclonine has been researched along with Brain Edema in 7 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, A | 1 |
| Castellani, RJ | 1 |
| Smith, MA | 1 |
| Muresanu, DF | 1 |
| Dey, PK | 2 |
| Sharma, HS | 3 |
| Sinha, RK | 3 |
| Aggarwal, Y | 2 |
| Winkler, T | 1 |
| Stålberg, E | 1 |
| Mohanty, S | 2 |
| Westman, J | 1 |
| Ray, AK | 1 |
| Olsson, Y | 1 |
| Pettersson, A | 1 |
| Cervos-Navarro, J | 1 |
7 other studies available for fenclonine and Brain Edema
| Article | Year |
|---|---|
5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.
Topics: 5-Hydroxytryptophan; Albumins; Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Brain Edema; C | 2019 |
Neural network detects the effects of p-CPA pre-treatment on brain electrophysiology in a rat model of focal brain injury.
Topics: Algorithms; Animals; Brain; Brain Edema; Brain Injuries; Cerebral Cortex; Disease Models, Animal; El | 2009 |
P-CPA pretreatment reverses the changes in sleep and behavior following acute immobilization stress rats.
Topics: Animals; Behavior, Animal; Brain Edema; Electroencephalography; Electromyography; Electrooculography | 2006 |
Depletion of serotonin synthesis with p-CPA pretreatment alters EEG in urethane anesthetized rats under whole body hyperthermia.
Topics: Anesthesia; Anesthetics; Animals; Blood-Brain Barrier; Brain; Brain Edema; Electroencephalography; F | 2007 |
p-Chlorophenylalanine, an inhibitor of serotonin synthesis reduces blood-brain barrier permeability, cerebral blood flow, edema formation and cell injury following trauma to the rat brain.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Capillary Permeability; Cell Survi | 2000 |
The role of serotonin in cerebral oedema.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Female; Fenclonine; Male; Rats; Serotoni | 1979 |
Release of endogenous neurochemicals may increase vascular permeability, induce edema and influence cell changes in trauma to the spinal cord.
Topics: Animals; Blood Pressure; Body Water; Brain Edema; Capillary Permeability; Carbon Dioxide; Fenclonine | 1992 |