fenclonine has been researched along with BH4 Deficiency in 55 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Infant rhesus monkeys were (a) fed a diet high in phenylalanine or (b) fed a diet high in p-chlorophenylalanine for the 1st 12 months of life, (c) selected from mothers fed a diet high in phenylalanine during pregnancy, (d) fed a diet low in phenylalanine, (e) maintained as controls, or (f) maintained as pair-fed controls." | 3.66 | Dietary and metabolic effects on rhesus social behavior: phenylalanine-related dietary alterations. ( Chamove, AS, 1980) |
| " Increased concentrations of phenylalanine and increased ratio of phenylalanine to tyrosine were demonstrated in blood from pregnant rats fed the experimental PKU diet from day 10 to 20 of pregnancy, in fetal blood and amniotic fluid of fetal animals from mothers fed the PKU diet, and in blood of rats fed the PKU diet for 28-30 days beginning at 20-21 days of age." | 3.65 | Biochemical effects of induced phenylketonuria in rats. ( Berry, HK; Butcher, RE; Kazmaier, KJ; Poncet, IB, 1975) |
| "Recent approaches for treating phenylketonuria focus on injectable medications that efficiently break down phenylalanine but sometimes result in detrimentally low phenylalanine levels." | 1.51 | Phenylalanine Monitoring via Aptamer-Field-Effect Transistor Sensors. ( Andrews, AM; Cheung, KM; Jung, ME; Nakatsuka, N; Stojanović, MN; Weiss, PS; Yang, H; Yang, KA; Ye, M; Zhao, C, 2019) |
| "Phenylketonuria is a genetic defect that leads to imbecility, if the diagnosis is not made directly after birth." | 1.26 | Phenylketonuria: clinical and experimental considerations revealed by the use of animal models. ( Lane, JD; Neuhoff, V, 1980) |
| "This degree of hyperphenylalaninaemia, persisting for 18h per day throughout a critical period of development, fulfils the primary criterion of a suitable animal model for phenylketonuria." | 1.26 | The regulation of phenylalanine hydroxylase in rat tissues in vivo. The maintenance of high plasma phenylalanine concentrations in suckling rats: a model for phenylketonuria. ( Delvalle, JA; Greengard, O, 1976) |
| "These manifestations of phenylketonuria were reproduced in rats treated with phenylacetate in amounts approximating those likely to be produced in phenylketonuria." | 1.26 | Myelin deficiency in experimental phenylketonuria: contribution of the aromatic acid metabolites of phenylalanine. ( Loo, YH; Scotto, J; Wisniewski, HM, 1978) |
| "Model phenylketonuria was induced in albino rats by injecting (at 1-20 days of age) and feeding (at 21-80 days) L-phenylalanine and D-L-para-chloro-phenylalanine." | 1.25 | Model phenylketonuria (PKU) in the albino rat: behaviroal, biochemical, and neuroanatomical effects. ( Brown, WJ; Copenhaver, JH; Gunter, R; Schalock, RL, 1975) |
| "An experimental phenylketonuria-like syndrome was produced in rats by oral administration of 1-phenylalanine (Phe, 500 mg/kg) and dl-p-chloro-phenylalanine (pCPA, 100-125 mg/kg) daily from the 2nd-3rd day of life to the age of 42 days." | 1.25 | Protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats. ( Airaksinen, MM; MacDonald, EJ; Marvola, M; Turakka, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (94.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (1.82) | 29.6817 |
| 2010's | 2 (3.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheung, KM | 1 |
| Yang, KA | 1 |
| Nakatsuka, N | 1 |
| Zhao, C | 1 |
| Ye, M | 1 |
| Jung, ME | 1 |
| Yang, H | 1 |
| Weiss, PS | 1 |
| Stojanović, MN | 1 |
| Andrews, AM | 1 |
| Simon, KR | 1 |
| Dos Santos, RM | 1 |
| Scaini, G | 1 |
| Leffa, DD | 1 |
| Damiani, AP | 1 |
| Furlanetto, CB | 1 |
| Machado, JL | 1 |
| Cararo, JH | 1 |
| Macan, TP | 1 |
| Streck, EL | 2 |
| Ferreira, GC | 1 |
| Andrade, VM | 1 |
| Schuck, PF | 1 |
| Loo, YH | 5 |
| Fulton, T | 1 |
| Miller, K | 1 |
| Wisniewski, HM | 2 |
| Chamove, AS | 2 |
| Benevenga, NJ | 1 |
| Steele, RD | 1 |
| Dienel, GA | 1 |
| Dwivedy, AK | 1 |
| Shah, SN | 1 |
| Lane, JD | 2 |
| Schöne, B | 1 |
| Langenbeck, U | 1 |
| Neuhoff, V | 2 |
| Fulton, TR | 1 |
| Triano, T | 1 |
| Rabe, A | 1 |
| Lo, GS | 1 |
| Longenecker, JB | 1 |
| Vorhees, CV | 3 |
| Butcher, RE | 3 |
| Berry, HK | 4 |
| Zanić-Grubisić, T | 1 |
| Lipovac, K | 1 |
| Sharma, SD | 1 |
| Cooley, C | 1 |
| De La Pava, E | 1 |
| Ambrus, CM | 1 |
| Edom, PT | 1 |
| Noriler, ME | 1 |
| Borges, LF | 1 |
| Pontes, ZL | 1 |
| Parolo, E | 1 |
| Dutra-Filho, CS | 1 |
| Wannmacher, CM | 1 |
| Wyse, AT | 1 |
| Murthy, LT | 1 |
| Avins, L | 1 |
| Guroff, G | 3 |
| Kuwabara, T | 1 |
| Brase, DA | 1 |
| Loh, HH | 1 |
| Valdivieso, F | 4 |
| Gimenez, C | 4 |
| Mayor, F | 4 |
| Rowe, VD | 1 |
| Fales, HM | 1 |
| Pisano, JJ | 1 |
| Andersen, AE | 2 |
| Poncet, IB | 1 |
| Kazmaier, KJ | 1 |
| Antonas, KN | 1 |
| Coulson, WF | 1 |
| Schalock, RL | 4 |
| Brown, WJ | 3 |
| Copenhaver, JH | 4 |
| Gunter, R | 2 |
| Airaksinen, MM | 1 |
| Turakka, H | 1 |
| Marvola, M | 1 |
| MacDonald, EJ | 1 |
| Delvalle, JA | 1 |
| Greengard, O | 1 |
| Luchins, D | 1 |
| Dhondt, JL | 2 |
| Farriaux, JP | 2 |
| Ugarte, M | 1 |
| Maties, M | 1 |
| Dautrevaux, M | 1 |
| Biserte, G | 1 |
| Scotto, J | 1 |
| Akeson, AL | 1 |
| Brunner, RL | 1 |
| Lasala, JM | 1 |
| Coscia, CJ | 1 |
| Benavides, J | 1 |
| Sanchez-Rubiales, M | 1 |
| Okano, Y | 1 |
| Chow, IZ | 1 |
| Isshiki, G | 1 |
| Inoue, A | 1 |
| Oura, T | 1 |
| Ledley, FD | 1 |
| Woo, SL | 1 |
| Pueschel, SM | 1 |
| Boylan, J | 1 |
| Ellenbogen, R | 1 |
| Kilbey, MM | 1 |
| Harris, RT | 1 |
| Presant, CA | 1 |
| Wiernik, PH | 1 |
| Serpick, AA | 1 |
| Schalock, R | 1 |
| Fuller, RW | 1 |
| Snoddy, HD | 1 |
| Wolen, RL | 1 |
| Coburn, SP | 1 |
| Sirlin, EM | 1 |
| Mack, K | 2 |
| Shihabi, ZK | 1 |
| Summer, GK | 1 |
| Edwards, DJ | 2 |
| Blau, K | 2 |
| Vacanti, JP | 1 |
| Carver, MJ | 2 |
| Gunter, RG | 1 |
| Tourian, A | 1 |
4 reviews available for fenclonine and BH4 Deficiency
| Article | Year |
|---|---|
Adverse effects of excessive consumption of amino acids.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Brain; Cattle; Diet; Disease Models, Ani | 1984 |
Progress in experimental phenylketonuria: a critical review.
Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Energy Metabolism; Female; Fenclonine; Glu | 1981 |
Urinary phenylalanine metabolites in preweanling rats treated with p-chlorophenylalanine and phenylalanine.
Topics: Animals; Disease Models, Animal; Fenclonine; Humans; Lactates; Phenylalanine; Phenylketonurias; Phen | 1975 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
1 trial available for fenclonine and BH4 Deficiency
| Article | Year |
|---|---|
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
51 other studies available for fenclonine and BH4 Deficiency
| Article | Year |
|---|---|
Phenylalanine Monitoring via Aptamer-Field-Effect Transistor Sensors.
Topics: Animals; Aptamers, Nucleotide; DNA; Electrochemical Techniques; Fenclonine; Mice; Phenylalanine; Phe | 2019 |
DNA damage induced by phenylalanine and its analogue p-chlorophenylalanine in blood and brain of rats subjected to a model of hyperphenylalaninemia.
Topics: Animals; Brain; DNA Damage; Fenclonine; Male; Phenylalanine; Phenylalanine Hydroxylase; Phenylketonu | 2013 |
Phenylacetate and brain dysfunction in experimental phenylketonuria: synaptic development.
Topics: Animals; Cerebral Cortex; Choline; Female; Fenclonine; gamma-Aminobutyric Acid; Humans; Male; Neurot | 1980 |
Analysis of learning in retarded monkeys.
Topics: Animals; Attention; Concept Formation; Discrimination, Psychological; Disease Models, Animal; Female | 1984 |
Chronic hyperphenylalaninemia produces cerebral hyperglycinemia in immature rats.
Topics: Amino Acids; Animals; Animals, Newborn; Brain; Fenclonine; Glycine; Humans; Liver; Phenylalanine; Ph | 1981 |
Effect of hyperphenylalaninemia on polyphosphoinositides content of rat brain.
Topics: Animals; Brain; Disease Models, Animal; Fenclonine; Humans; Kinetics; Phenylalanine; Phenylketonuria | 1982 |
Characterization of experimental phenylketonuria. Augmentation of hyperphenylalaninemia with alpha-methylphenylalanine and p-chlorophenylalanine.
Topics: Age Factors; Amino Acids; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Disease Models, A | 1980 |
Dietary and metabolic effects on rhesus social behavior: phenylalanine-related dietary alterations.
Topics: Aggression; Animals; Female; Fenclonine; Haplorhini; Humans; Macaca mulatta; Phenylalanine; Phenylke | 1980 |
Phenylketonuria: clinical and experimental considerations revealed by the use of animal models.
Topics: Animals; Brain; Cerebellum; Disease Models, Animal; Fenclonine; Humans; Male; Neurons; Phenylalanine | 1980 |
Phenylacetate and the enduring behavioral deficit in experimental phenylketonuria.
Topics: Animals; Behavior, Animal; Body Weight; Escape Reaction; Female; Fenclonine; Humans; Hyperkinesis; M | 1980 |
Induction of an experimental phenylketonuria-like condition in infant rats during the first 2 weeks after birth.
Topics: Animals; Animals, Newborn; Diet; Disease Models, Animal; Female; Fenclonine; Humans; Male; Methotrex | 1981 |
Disturbances of amino acid transport in rats with experimental hyperphenylalaninaemia.
Topics: Amino Acids; Animals; Cerebral Cortex; Disease Models, Animal; Fenclonine; Glycine; Humans; Leucine; | 1981 |
Development of a refractory stage in a dog model for phenylketonuria.
Topics: Animals; Diet; Disease Models, Animal; Dogs; Fenclonine; Humans; Liver; Phenylalanine Hydroxylase; P | 1981 |
Effect of phenylalanine and p-chlorophenylalanine on Na+, K+-ATPase activity in the synaptic plasma membrane from the cerebral cortex of rats.
Topics: Animals; Animals, Newborn; Body Weight; Ca(2+) Mg(2+)-ATPase; Cerebral Cortex; Fenclonine; Nerve Tis | 2000 |
Inhibition of phenylalanine hydroxylase activity by alpha-methyl tyrosine, a potent inhibitor of tyrosine hydroxylase.
Topics: Animals; Disease Models, Animal; Fenclonine; Humans; Kidney; Liver; Methyltyrosines; Mice; Phenylala | 1975 |
Ultrastructural changes in rat optic nerve associated with hyperphenylalaninemia induced by para-chlorophenylalanine and phenylalanine.
Topics: Animals; Astrocytes; Axons; Cytoplasm; Disease Models, Animal; Endoplasmic Reticulum; Fenclonine; Go | 1975 |
Possible role of 5-hydroxyptamine in minimal brain dysfunction.
Topics: Amphetamine; Animal Nutritional Physiological Phenomena; Animals; Attention Deficit Disorder with Hy | 1975 |
In vivo inhibition of rat liver phenylalanine hydroxylase by p-chlorophenylalanine and Esculin. Experimental model of phenylketonuria.
Topics: Animals; Disease Models, Animal; Esculin; Female; Fenclonine; Flavonoids; Humans; Liver; Phenylalani | 1975 |
Urinary metabolites of phenylalanine in the preweanling rat treated with p-chlorophenylalanine and phenylalanine.
Topics: Animals; Chromatography; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fenclonin | 1975 |
Biochemical effects of induced phenylketonuria in rats.
Topics: Amino Acids; Amniotic Fluid; Animals; Brain; Diet; Female; Fenclonine; Fetal Blood; Humans; Phenylac | 1975 |
Brain uptake and protein incorporation of amino acids studied in rats subjected to prolonged hyperphenylalaninaemia.
Topics: Amino Acids; Animals; Brain; Disease Models, Animal; Female; Fenclonine; Glycine; Humans; Leucine; L | 1975 |
Model phenylketonuria (PKU) in the albino rat: behaviroal, biochemical, and neuroanatomical effects.
Topics: Animals; Axons; Body Weight; Disease Models, Animal; Emotions; Fenclonine; Humans; Learning; Liver; | 1975 |
Protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Body Weight; Brain; Female; Fenclonine; Humans; Hydr | 1975 |
The regulation of phenylalanine hydroxylase in rat tissues in vivo. The maintenance of high plasma phenylalanine concentrations in suckling rats: a model for phenylketonuria.
Topics: Animals; Brain; Disease Models, Animal; Fenclonine; Humans; Kidney; Liver; Male; Phenylalanine; Phen | 1976 |
Study of blood aminoacids in experimental hyperphenylalaninemia.
Topics: Amino Acids; Animals; Disease Models, Animal; Fenclonine; Humans; Male; Phenylalanine; Phenylketonur | 1977 |
Free amino acids in the tissues of rats with experimentally induced phenylketonuria.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Esculin; Fenclonine; Humans; Liver; Male; Phenylalanin | 1977 |
A new experimental model of hyperphenylalaninemia in rat. Effect of p-chlorophenylalanine and cotrimoxazole.
Topics: Animals; Disease Models, Animal; Drug Combinations; Fenclonine; Humans; Kidney; Liver; Male; Phenyla | 1977 |
Myelin deficiency in experimental phenylketonuria: contribution of the aromatic acid metabolites of phenylalanine.
Topics: Animals; Brain; Disease Models, Animal; Female; Fenclonine; Humans; Male; Membrane Lipids; Myelin Pr | 1978 |
Brain pyruvate kinase activity in PKU model systems.
Topics: Animals; Body Weight; Brain; Female; Fenclonine; Fetus; Humans; Organ Size; Phenylalanine; Phenylket | 1979 |
Accumulation of a tetrahydroisoquinoline in phenylketonuria.
Topics: Adolescent; Animals; Brain; Child; Child, Preschool; Dopamine beta-Hydroxylase; Fenclonine; Humans; | 1979 |
Experimental phenylketonuria: metabolic studies in rat liver.
Topics: Animals; Disease Models, Animal; Fasting; Female; Fenclonine; Fructosephosphates; Gluconeogenesis; G | 1977 |
Effects of phenylalanine loading on protein synthesis in the fetal heart and brain of rat: an experimental approach to maternal phenylketonuria.
Topics: Animals; Brain; Carbon Radioisotopes; Disease Models, Animal; Female; Fenclonine; Fetal Heart; Fetus | 1986 |
P-chlorophenylalanine does not inhibit production of recombinant human phenylalanine hydroxylase in NIH3T3 cells or E. coli.
Topics: Animals; Cell Line; Escherichia coli; Fenclonine; Humans; Mice; Phenylalanine Hydroxylase; Phenylket | 1987 |
Studies on experimentally induced hyperphenylalaninemia.
Topics: Animals; Disease Models, Animal; Drug Combinations; Female; Fenclonine; Phenylalanine; Phenylalanine | 1988 |
Behavioral, biochemical and maturation effects of early DL-para-chlorophenylalanine treatment.
Topics: Animals; Behavior, Animal; Body Weight; Bone Development; Brain Chemistry; Female; Fenclonine; Human | 1971 |
Effects of phenylalanine and related compounds on serum alkaline phosphatase assay.
Topics: Adult; Alkaline Phosphatase; Bone Diseases; Chemistry, Clinical; Chloramphenicol; Fenclonine; Humans | 1971 |
Enduring behavioral changes in rats with experimental phenylketonuria.
Topics: Aggression; Animals; Appetitive Behavior; Avoidance Learning; Behavior, Animal; Brain; Defecation; D | 1972 |
Cataractogenesis in infant rats with model phenylketonuria.
Topics: Age Factors; Animals; Animals, Newborn; Cataract; Disease Models, Animal; Female; Fenclonine; Humans | 1972 |
Effect of glucagon and p-chlorophenylalanine on hepatic enzymes that metabolize phenylalanine.
Topics: Adolescent; Adult; Animals; Fenclonine; Glucagon; Humans; Liver; Male; Middle Aged; Phenylalanine; P | 1972 |
Effect of hyperphenylalaninemia on vitamin B 6 metabolism in developing rat brain.
Topics: Animals; Brain; Carbon Isotopes; Chromatography, Ion Exchange; Female; Fenclonine; Humans; Injection | 1972 |
Effect of vitamin B 6 on phenylalanine metabolism in the brain of normal and p-chlorophenylalanine-treated rats.
Topics: Animals; Brain; Carbon Isotopes; Female; Fenclonine; Humans; Injections, Intraperitoneal; Injections | 1972 |
Determination of serum and urinary phenylalanine by gas chromatography.
Topics: Amino Acids; Chromatography, Gas; Fenclonine; Humans; Lactates; Phenylalanine; Phenylketonurias | 1973 |
Aromatic acids derived from phenylalanine in the tissues of rats with experimentally induced phenylketonuria-like characteristics.
Topics: Animals; Benzoates; Brain; Chromatography, Gas; Fenclonine; Humans; Lactates; Liver; Male; Mandelic | 1972 |
Phenethylamines in brain and liver of rats with experimentally induced phenylketonuria-like characteristics.
Topics: Animals; Brain; Centrifugation, Density Gradient; Chromatography, Gas; Ethanolamines; Fenclonine; Hu | 1973 |
Experimental maternal hyperphenylalaninemia: disaggregation of fetal brain ribosomes.
Topics: Animals; Brain; Brain Chemistry; Centrifugation, Density Gradient; Female; Fenclonine; Fetus; Humans | 1973 |
The effects of parachlorophenylalanine on lens ultrastructure.
Topics: Animals; Cataract; Cell Nucleus; Cytoplasm; Endoplasmic Reticulum; Epithelial Cells; Female; Fenclon | 1973 |
Behavioral effects of experimental maternal hyperphenylalaninemia.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Exploratory | 1973 |
Experimental maternal hyperphenylalaninemia: biochemical effects and offspring development.
Topics: Aggression; Animals; Animals, Newborn; Body Weight; Brain; Brain Chemistry; Disease Models, Animal; | 1974 |
Reduced activity in rats with induced phenylketonuria.
Topics: Animals; Body Weight; Diet; Eating; Exploratory Behavior; Fenclonine; Humans; Male; Motor Activity; | 1972 |
Glycolysis in the brain and liver of rats with experimentally induced phenylketonuria.
Topics: Animals; Autoanalysis; Brain; Chromatography, Ion Exchange; Esculin; Female; Fenclonine; Glycolysis; | 1974 |
Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase.
Topics: Animals; Brain; Brain Chemistry; Chemical Phenomena; Chemistry; Disease Models, Animal; Electrophore | 1973 |