fenclonine has been researched along with Anxiety in 27 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively." | 7.71 | Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. ( Ong, YP; Wong, PT, 2001) |
| "Fluoxetine, a selective serotonin reuptake inhibitor, shows moderate efficacy and potency in the rat forced swimming depression test and the shock-induced ultrasonic vocalization anxiety test, whereas the 5-HT(1A) receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is highly efficient and potent in both models." | 3.72 | 5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat. ( Dalmus, M; De Vry, J; Jentzsch, KR; Melon, C; Schreiber, R, 2004) |
| "The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively." | 3.71 | Acute antidepressant-like and antianxiety-like effects of tryptophan in mice. ( Ong, YP; Wong, PT, 2001) |
| "The effects of acute and repeated treatment with the 5-HT1A receptor ligand ipsapirone on hippocampal excitatory synaptic transmission and in an ultrasonic vocalization anxiety test were investigated in the rat." | 3.69 | Effect of repeated ipsapirone treatment on hippocampal excitatory synaptic transmission in the freely behaving rat: role of 5-HT1A receptors and relationship to anxiolytic effect. ( Anwyl, R; De Vry, J; Rowan, MJ; Xu, L, 1997) |
| "Previous work suggests that the elevated plus-maze test of anxiety is insensitive to the anxiolytic effects of the novel anxiolytic buspirone, which shows an anxiogenic-like profile in this test." | 3.67 | An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone. ( Moser, PC, 1989) |
| "Caffeine-treated adolescent male rats were exposed to caffeine (0." | 1.56 | Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat. ( Abdulzahir, A; Hwang, K; Sanford, J; Turgeon, SM, 2020) |
| "The anxiety-reducing effect of long-term administration of serotonin reuptake inhibitors is usually seen only in subjects with anxiety disorders, and such patients are also abnormally inclined to experience a paradoxical anxiety-enhancing effect of acute serotonin reuptake inhibition." | 1.42 | Differences in Anxiety-Like Behavior within a Batch of Wistar Rats Are Associated with Differences in Serotonergic Transmission, Enhanced by Acute SRI Administration, and Abolished By Serotonin Depletion. ( Eriksson, E; Hagsäter, M; Näslund, J; Nilsson, S; Nissbrandt, H; Pettersson, R; Studer, E, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 4 (14.81) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Turgeon, SM | 1 |
| Abdulzahir, A | 1 |
| Hwang, K | 1 |
| Sanford, J | 1 |
| Saadati, H | 1 |
| Sadegzadeh, F | 1 |
| Sakhaie, N | 1 |
| Panahpour, H | 1 |
| Sagha, M | 1 |
| Hagsäter, SM | 2 |
| Pettersson, R | 3 |
| Holmäng, A | 1 |
| Eriksson, E | 4 |
| Silva, EF | 1 |
| Silva, AI | 1 |
| Asth, L | 1 |
| Souza, LS | 1 |
| Zaveri, NT | 1 |
| Guerrini, R | 1 |
| Calo', G | 1 |
| Ruzza, C | 1 |
| Gavioli, EC | 1 |
| Maximino, C | 1 |
| Puty, B | 1 |
| Benzecry, R | 1 |
| Araújo, J | 1 |
| Lima, MG | 1 |
| de Jesus Oliveira Batista, E | 1 |
| Renata de Matos Oliveira, K | 1 |
| Crespo-Lopez, ME | 1 |
| Herculano, AM | 1 |
| Näslund, J | 2 |
| Studer, E | 2 |
| Nilsson, K | 1 |
| Westberg, L | 1 |
| Hagsäter, M | 1 |
| Nilsson, S | 1 |
| Nissbrandt, H | 1 |
| Das, SK | 1 |
| Barhwal, K | 1 |
| Hota, SK | 1 |
| Thakur, MK | 1 |
| Srivastava, RB | 1 |
| Vataeva, LA | 1 |
| Kudrin, VS | 1 |
| Vershinina, EA | 1 |
| Mosin, VM | 1 |
| Tiul'kova, EI | 1 |
| Otellin, VA | 1 |
| Tran, L | 1 |
| Keele, NB | 1 |
| Kuo, JR | 1 |
| Cheng, YH | 1 |
| Chen, YS | 1 |
| Chio, CC | 1 |
| Gean, PW | 1 |
| De Vry, J | 2 |
| Schreiber, R | 1 |
| Melon, C | 1 |
| Dalmus, M | 1 |
| Jentzsch, KR | 1 |
| Bechtholt, AJ | 1 |
| Hill, TE | 1 |
| Lucki, I | 1 |
| Graeff, FG | 1 |
| Imaizumi, M | 1 |
| Miyazaki, S | 1 |
| Onodera, K | 1 |
| Xu, L | 1 |
| Anwyl, R | 1 |
| Rowan, MJ | 1 |
| Koprowska, M | 1 |
| Krotewicz, M | 1 |
| Romaniuk, A | 1 |
| Strzelczuk, M | 1 |
| Wieczorek, M | 1 |
| Nazar, M | 2 |
| Siemiatkowski, M | 2 |
| Bidziński, A | 1 |
| Członkowska, A | 2 |
| Sienkiewicz-Jarosz, H | 2 |
| Płaźnik, A | 2 |
| Wong, PT | 1 |
| Ong, YP | 1 |
| File, SE | 1 |
| Hyde, JR | 1 |
| Wilson, CA | 1 |
| Gonzalez, I | 1 |
| Farabollini, F | 1 |
| Critchley, MA | 1 |
| Njung'e, K | 1 |
| Handley, SL | 1 |
| Moser, PC | 1 |
| Söderpalm, B | 1 |
| Engel, JA | 1 |
| Hartmann, RJ | 1 |
| Geller, I | 1 |
1 review available for fenclonine and Anxiety
| Article | Year |
|---|---|
Minor tranquilizers and brain defense systems.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Columbidae; Defense Mechanisms; Fear | 1981 |
26 other studies available for fenclonine and Anxiety
| Article | Year |
|---|---|
Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat.
Topics: Age Factors; alpha-Methyltyrosine; Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behav | 2020 |
Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats.
Topics: Animals; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Cognition; Female; Fenclonine; Male; Rat | 2021 |
Serotonin depletion reduces both acquisition and expression of context-conditioned fear.
Topics: Animals; Anxiety; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Fencl | 2021 |
Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test.
Topics: Aggression; Agonistic Behavior; Animals; Anxiety; Bipolar Disorder; Carbamazepine; Cycloheptanes; De | 2019 |
Role of serotonin in zebrafish (Danio rerio) anxiety: relationship with serotonin levels and effect of buspirone, WAY 100635, SB 224289, fluoxetine and para-chlorophenylalanine (pCPA) in two behavioral models.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Buspirone; Disease Models, Animal; D | 2013 |
Serotonin depletion counteracts sex differences in anxiety-related behaviour in rat.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Female; Fenclonine; Male; Maze Learning; Rats; Rats, Wist | 2013 |
Differences in Anxiety-Like Behavior within a Batch of Wistar Rats Are Associated with Differences in Serotonergic Transmission, Enhanced by Acute SRI Administration, and Abolished By Serotonin Depletion.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Citalopram; Exploratory Behavior; Fenclonine; Individu | 2015 |
Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats.
Topics: Animals; Anxiety; Cyclic AMP Response Element-Binding Protein; Dendrites; Depression; Fenclonine; Hi | 2015 |
Serotonin depletion eliminates sex differences with respect to context-conditioned immobility in rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Conditioning, Psychological; Fear; Female; Fenclonine; Immobi | 2016 |
Maternal para-chlorophenylalanine exposure modifies central monoamines and behaviors in the adult offspring.
Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Environment; Female; Fencl | 2008 |
P-chlorophenylalanine increases glutamate receptor 1 transcription in rat amygdala.
Topics: Amygdala; Animals; Anxiety; Fenclonine; Gene Expression Regulation; Male; Rats; Rats, Sprague-Dawley | 2011 |
Involvement of extracellular signal regulated kinases in traumatic brain injury-induced depression in rodents.
Topics: Animals; Anxiety; Blotting, Western; Brain Injuries; Coloring Agents; Depression; Extracellular Sign | 2013 |
5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidep | 2004 |
Anxiolytic effect of serotonin depletion in the novelty-induced hypophagia test.
Topics: 5-Hydroxytryptophan; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; | 2007 |
Effects of theophylline in p-chlorophenylalanine-treated mice in a light/dark test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Darkness; Fenclonine; Light; Male; M | 1996 |
Effect of repeated ipsapirone treatment on hippocampal excitatory synaptic transmission in the freely behaving rat: role of 5-HT1A receptors and relationship to anxiolytic effect.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Electrophysiology; Fenclonine; Hippocampus; Injections, Intra | 1997 |
Behavioral and neurochemical alterations evoked by p-Chlorophenylalanine application in rats examined in the light-dark crossing test.
Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Fenclonine; Lighting; Male | 1999 |
The influence of serotonin depletion on rat behavior in the Vogel test and brain 3H-zolpidem binding.
Topics: 5,7-Dihydroxytryptamine; Animals; Anxiety; Autoradiography; Brain; Conflict, Psychological; Corpus S | 1999 |
The role of the hippocampus and 5-HT/GABA interaction in the central effects of benzodiazepine receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepinones; Brain; Conflict, Psychological; Dentate Gy | 1999 |
Acute antidepressant-like and antianxiety-like effects of tryptophan in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Dose-Res | 2001 |
The effects of p-chlorophenylalanine and ethanolamine-O-sulphate in an animal test of anxiety.
Topics: Animals; Anxiety; Brain Chemistry; Ethanolamines; Fenclonine; gamma-Aminobutyric Acid; Humans; Male; | 1977 |
Behavioural effects in adulthood of neonatal manipulation of brain serotonin levels in normal and androgenized females.
Topics: 5-Hydroxytryptophan; Androgens; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Brain Chemistr | 1992 |
Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions.
Topics: 5,7-Dihydroxytryptamine; Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Fencl | 1992 |
An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone.
Topics: Animals; Anxiety; Behavior, Animal; Buspirone; Diazepam; Fenclonine; Male; Rats; Rats, Inbred Strain | 1989 |
Does the PCPA induced anticonflict effect involve activation of the GABAA/benzodiazepine chloride ionophore receptor complex?
Topics: Animals; Anxiety; Bicuculline; Brain; Dose-Response Relationship, Drug; Fenclonine; Flumazenil; Male | 1989 |
P-Chlorophenylalanine effects on a conditioned emotional response in rats.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Conditioning, Operant; Conditioning, Psychological; Electrosh | 1971 |