fenclonine has been researched along with Aging in 37 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicotine (0." | 1.29 | Depletion of serotonin, dopamine and noradrenaline in aged rats decreases the therapeutic effect of nicotine, but not of tetrahydroaminoacridine. ( Aroviita, L; Kivipelto, M; Riekkinen, M; Riekkinen, P; Taskila, K, 1996) |
| ") ameliorated all the memory impairments except those induced by cysteamine or fimbria fornix lesion, and the dose-response curves were bell shaped with maximal response at 1 to 3." | 1.29 | FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action. ( Maeda, N; Matsuoka, N; Ohkubo, Y; Yamaguchi, I; Yamazaki, M, 1996) |
| "Cimetidine failed to increase PRL in rats of 1 and 4 days of age." | 1.27 | Serotoninergic involvement in the cimetidine-induced prolactin release. ( Becú, D; Libertun, C, 1983) |
| "Similarly, catalepsy induced by (-)-sulpiride (40 mg/kg, i." | 1.27 | Influence of (-)-sulpiride and YM-09151-2 on stereotyped behavior in chicks and catalepsy in rats. ( Wambebe, C, 1987) |
| "Pretreatment with cyproheptadine and vinblastine, however, prevented only the increased permeability of the blood-brain barrier; the plasma and level of 5-HT in brain continued to remain high." | 1.27 | Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats. ( Dey, PK; Sharma, HS, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (54.05) | 18.7374 |
| 1990's | 9 (24.32) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Limón-Morales, O | 1 |
| Soria-Fregozo, C | 1 |
| Arteaga-Silva, M | 1 |
| Vázquez-Palacios, G | 1 |
| Bonilla-Jaime, H | 1 |
| Matsukawa, M | 1 |
| Nakadate, K | 1 |
| Ishihara, I | 1 |
| Okado, N | 1 |
| Vataeva, LA | 1 |
| Kudrin, VS | 1 |
| Vershinina, EA | 1 |
| Mosin, VM | 1 |
| Tiul'kova, EI | 1 |
| Otellin, VA | 1 |
| Walker, RF | 3 |
| Kamyshev, NG | 1 |
| Smirnova, GP | 1 |
| Savvateeva, EV | 1 |
| Medvedeva, AV | 1 |
| Ponomarenko, VV | 1 |
| Becú, D | 1 |
| Libertun, C | 1 |
| Ruckebusch, Y | 1 |
| Bardon, T | 1 |
| Cooper, RL | 1 |
| Timiras, PS | 2 |
| Popova, NK | 1 |
| Lobacheva, II | 1 |
| Goodrich, C | 1 |
| Wilk, C | 1 |
| McLeod, SD | 1 |
| Cairncross, KD | 1 |
| Sharma, HS | 2 |
| Westman, J | 1 |
| Navarro, JC | 1 |
| Dey, PK | 2 |
| Nyberg, F | 1 |
| Riekkinen, M | 1 |
| Aroviita, L | 1 |
| Kivipelto, M | 1 |
| Taskila, K | 1 |
| Riekkinen, P | 1 |
| Yamazaki, M | 1 |
| Matsuoka, N | 1 |
| Maeda, N | 1 |
| Ohkubo, Y | 1 |
| Yamaguchi, I | 1 |
| Tsai, CL | 3 |
| Wang, LH | 3 |
| Persico, AM | 2 |
| Altamura, C | 1 |
| Calia, E | 1 |
| Puglisi-Allegra, S | 1 |
| Ventura, R | 1 |
| Lucchese, F | 1 |
| Keller, F | 2 |
| Chang, CF | 1 |
| Kao, CC | 1 |
| Mengual, E | 1 |
| Moessner, R | 1 |
| Hall, FS | 1 |
| Revay, RS | 1 |
| Sora, I | 1 |
| Arellano, J | 1 |
| DeFelipe, J | 1 |
| Gimenez-Amaya, JM | 1 |
| Conciatori, M | 1 |
| Marino, R | 1 |
| Baldi, A | 1 |
| Cabib, S | 1 |
| Pascucci, T | 1 |
| Uhl, GR | 1 |
| Murphy, DL | 1 |
| Lesch, KP | 1 |
| Hall, SF | 1 |
| Fang, LS | 1 |
| Shishkina, GT | 1 |
| Dygalo, NN | 1 |
| Hoff, KM | 1 |
| Baker, PC | 1 |
| Buda, RE | 1 |
| Janoff, AS | 1 |
| Rosenberg, B | 1 |
| File, SE | 1 |
| Del Valle, JA | 1 |
| Greengard, O | 1 |
| Bond, EF | 1 |
| Heitkemper, MM | 1 |
| Gruver, MK | 1 |
| Ho, ML | 1 |
| Hsu, HK | 1 |
| Young, FJ | 1 |
| Hsu, C | 1 |
| Peng, MT | 1 |
| Montilla, P | 1 |
| Salcedo, M | 1 |
| Muñoz, MC | 1 |
| Montilla, MC | 1 |
| Johnston, HM | 1 |
| Payne, AP | 1 |
| Gilmore, DP | 1 |
| Wilson, CA | 1 |
| Park, DH | 1 |
| Paivarinta, H | 1 |
| Joh, TH | 1 |
| Wambebe, C | 1 |
| Saavedra, JM | 1 |
| Coyle, JT | 1 |
| Axelrod, J | 1 |
| Copenhaver, JH | 1 |
| Carver, MJ | 1 |
| Johnson, EA | 1 |
| Saxton, MJ | 1 |
| Mabry, PD | 1 |
| Campbell, BA | 1 |
| Nordyke, EL | 1 |
| Roach, MK | 1 |
| Adlard, BP | 1 |
| Smart, JL | 1 |
37 other studies available for fenclonine and Aging
| Article | Year |
|---|---|
Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Body Temperature; Clomipra | 2014 |
Synaptic loss following depletion of noradrenaline and/or serotonin in the rat visual cortex: a quantitative electron microscopic study.
Topics: Aging; Animals; Animals, Newborn; Benzylamines; Cell Count; Drug Interactions; Fenclonine; Male; Mic | 2003 |
Behavioral alteration in the adult rats prenatally exposed to para-chlorophenylalanine.
Topics: Aging; Animals; Avoidance Learning; Behavior, Animal; Brain; Brain Chemistry; Exploratory Behavior; | 2007 |
Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrous rats.
Topics: 5-Hydroxytryptophan; Aging; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Castration; Estradi | 1982 |
The influence of serotonin and p-chlorophenylalanine on locomotor activity of Drosophila melanogaster.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Fenclonine; Motor | 1983 |
Serotoninergic involvement in the cimetidine-induced prolactin release.
Topics: Aging; Animals; Cimetidine; Female; Fenclonine; Luteinizing Hormone; Male; Methysergide; Prolactin; | 1983 |
[The motoricity cycle of the small intestine].
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Cattle; Electric Conductivity; Female; Fenclo | 1984 |
Constant estrus: role of rostral hypothalamic monoamines in development of reproductive dysfunction in aging rats.
Topics: Aging; Animals; Catecholamines; Diestrus; Disease Models, Animal; Ditiocarb; Estrus; Female; Fenclon | 1980 |
Loss of serotonin circadian rhythms in the pineal gland of androgenized female rats.
Topics: Aging; Animals; Circadian Rhythm; Estrus; Female; Fenclonine; Hypothyroidism; Luteinizing Hormone; P | 1980 |
[Participation of the brain serotoninergic system in creating the stress reactivity of the hypophyseal-adrenal axis].
Topics: Aging; Animals; Animals, Newborn; Brain; Fenclonine; Male; Pituitary-Adrenal System; Rats; Rats, Inb | 1981 |
Temperature preferences and the effect of changes in serotonin in maturing mice.
Topics: 5-Hydroxytryptophan; Aging; Animals; Choice Behavior; Fenclonine; Mice; Serotonin; Temperature | 1981 |
Preliminary evidence of a synergistic alpha 1- and beta 1-adrenoceptor regulation of rat pineal hydroxyindole-O-methyltransferase.
Topics: Acetylserotonin O-Methyltransferase; Aging; Animals; Body Weight; Circadian Rhythm; Doxazosin; Fencl | 1995 |
Probable involvement of serotonin in the increased permeability of the blood-brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Antineoplastic Agents, Phytogenic; Blood Pressure; Blood-Br | 1995 |
Depletion of serotonin, dopamine and noradrenaline in aged rats decreases the therapeutic effect of nicotine, but not of tetrahydroaminoacridine.
Topics: Aging; Animals; Behavior, Animal; Dopamine; Fenclonine; Frontal Lobe; Male; Nicotine; Norepinephrine | 1996 |
FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action.
Topics: Aging; Animals; Behavior, Animal; Benzamides; Brain; Cysteamine; Fenclonine; Male; Memory; Nootropic | 1996 |
Effects of gonadal steroids on the serotonin synthesis and metabolism in the early developing tilapia brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Estradiol; Fenclonine; Methyltestosterone; Monoamine Oxidas | 1999 |
Serotonin depletion and barrel cortex development: impact of growth impairment vs. serotonin effects on thalamocortical endings.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Fenclonine; Hydroxyindoleacetic Acid; Organ Si | 2000 |
Effects of gonadal steroids on brain serotonergic and aromatase activity during the critical period of sexual differentiation in tilapia, Oreochromis mossambicus.
Topics: Aging; Animals; Aromatase; Brain; Estradiol; Female; Fenclonine; Gonadal Steroid Hormones; Male; Met | 2000 |
Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release.
Topics: Aging; Animals; Biogenic Monoamines; Carrier Proteins; Extracellular Space; Fenclonine; GABA Plasma | 2001 |
Estradiol and para-chlorophenylalanine downregulate the expression of brain aromatase and estrogen receptor-alpha mRNA during the critical period of feminization in tilapia (Oreochromis mossambicus).
Topics: Actins; Aging; Animals; Aromatase; Brain; Down-Regulation; Estradiol; Estrogen Receptor alpha; Estro | 2001 |
Role of the serotoninergic system in the acceleration of sexual maturation in wild Norway rats selected for reduced aggressiveness toward humans.
Topics: 5-Hydroxytryptophan; Aggression; Aging; Animals; Epididymis; Female; Fenclonine; Humans; Hypothalamu | 2000 |
Effects of parachlorophenylalanine on indoleamines in maturing mouse brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Fenclonine; Hydroxyindoleacetic Acid; Mice; Serotonin | 1977 |
Chemically evoked hypothermia in the mouse: towards a method for investigating thermodynamic parameters of aging and death in mammals.
Topics: Adaptation, Physiological; Aging; Animals; Chlorpromazine; Drug Synergism; Female; Fenclonine; Hypot | 1978 |
Exploration in immature rats: effects of drugs.
Topics: Aging; Animals; Dextroamphetamine; Exploratory Behavior; Fenclonine; Humans; Male; Rats; Scopolamine | 1978 |
Isoenzyme composition of hepatic phenylalanine hydroxylase in developing rats after treatment with cortisol, alpha-methylphenylalanine and p-chlorophenylalanine in vivo.
Topics: Aging; Animals; Animals, Newborn; Fenclonine; Fetus; Hydrocortisone; Isoenzymes; Liver; Male; Phenyl | 1978 |
Mediation of thyrotropin-releasing hormone induced gastric motility increases in developing rats.
Topics: Aging; Analysis of Variance; Animals; Atropine; Dose-Response Relationship, Drug; Drug Interactions; | 1992 |
Improvement of sexual behavior in aged rats by p-chlorophenylalanine and methysergide.
Topics: Aging; Animals; Female; Fenclonine; Male; Methysergide; Rats; Serotonin; Sexual Behavior, Animal | 1992 |
[Cerebral serotonin and the hypothalamo-hypophyseal-adrenal system of the rat during aging].
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aging; Animals; Brain; Brain Chemistry; Corticoste | 1991 |
Neonatal serotonin reduction alters the adult feminine sexual behaviour of golden hamsters.
Topics: Aging; Animals; Animals, Newborn; Cricetinae; Female; Fenclonine; Hydroxyindoleacetic Acid; Hypothal | 1990 |
Tryptophan hydroxylase activity in hypothalamus and brainstem of neonatal and adult rats treated with hydrocortisone or parachlorophenylalanine.
Topics: Aging; Animals; Animals, Newborn; Brain Stem; Enzyme Inhibitors; Female; Fenclonine; Hydrocortisone; | 1989 |
Influence of (-)-sulpiride and YM-09151-2 on stereotyped behavior in chicks and catalepsy in rats.
Topics: Aging; Animals; Antipsychotic Agents; Benzamides; Catalepsy; Chickens; Dextroamphetamine; Fenclonine | 1987 |
Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats.
Topics: Aging; Animals; Blood Pressure; Blood-Brain Barrier; Body Temperature; Cyproheptadine; Diazepam; Fem | 1986 |
Developmental characteristics of phenylethanolamine and octopamine in the rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Chromatography, Thin Layer; Dopamine beta-Hydroxylase; Etha | 1974 |
Effect of para-chlorophenylalanine on the growth and development of the fetal, neonatal, and adult rat.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Feeding Behavior; Female; Fenclonine; Fetus; G | 1970 |
Ontogeny of serotonergic inhibition of behavioral arousal in the rat.
Topics: Aging; Amphetamine; Animals; Animals, Newborn; Arousal; Behavior, Animal; Brain; Brain Chemistry; Do | 1974 |
Effect of p-chlorophenylalanine and L-phenylalanine on deoxyribonucleic acid and protein content of developing rat cerebellum.
Topics: Aging; Animals; Body Weight; Brain Chemistry; Cerebellum; DNA; Female; Fenclonine; Nerve Tissue Prot | 1974 |
Some aspects of the behavior of young and adult rats treated with p-chlorophenylalanine in infancy.
Topics: Aging; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Brain; Brain Chemistry; Cere | 1974 |