fenclonine has been researched along with Acute Post-Traumatic Stress Disorder in 2 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using a model of repeated trauma in rats, we observed significant spatial memory impairment together with significantly increased 5HT(1A) receptor density (B(max)), decreased 5HT(1A) receptor affinity (K(d)), and significantly increased 5HT(2A) receptor affinity on day 7 poststress." | 1.32 | Serotonin and stress: protective or malevolent actions in the biobehavioral response to repeated trauma? ( Brand, L; Harvey, BH; Naciti, C; Stein, DJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nikaido, Y | 1 |
| Yamada, J | 1 |
| Migita, K | 1 |
| Shiba, Y | 1 |
| Furukawa, T | 1 |
| Nakashima, T | 1 |
| Ueno, S | 1 |
| Harvey, BH | 1 |
| Naciti, C | 1 |
| Brand, L | 1 |
| Stein, DJ | 1 |
2 other studies available for fenclonine and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
cis-3-Hexenol and trans-2-hexenal mixture prevents development of PTSD-like phenotype in rats.
Topics: Aldehydes; Animals; Conditioning, Psychological; Disease Models, Animal; Drug Evaluation, Preclinica | 2016 |
Serotonin and stress: protective or malevolent actions in the biobehavioral response to repeated trauma?
Topics: Animals; Behavior; Fenclonine; Fluoxetine; Maze Learning; Memory; Psychomotor Performance; Rats; Rec | 2004 |