fenamic acid has been researched along with Cystic Fibrosis in 17 studies
fenamic acid: has chloride and potassium channel-blocking activity; RN given refers to parent cpd
fenamic acid : An aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, which mediates transepithelial Cl- transport in a variety of epithelia, including airway, intestine, pancreas, and sweat duct." | 1.30 | Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells. ( Loffing, J; McCoy, D; Moyer, BD; Stanton, BA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 10 (58.82) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Michoud, MC | 1 |
| Robert, R | 1 |
| Hassan, M | 1 |
| Moynihan, B | 1 |
| Haston, C | 1 |
| Govindaraju, V | 1 |
| Ferraro, P | 1 |
| Hanrahan, JW | 1 |
| Martin, JG | 1 |
| Finkbeiner, WE | 1 |
| Zlock, LT | 1 |
| Morikawa, M | 1 |
| Lao, AY | 1 |
| Dasari, V | 1 |
| Widdicombe, JH | 1 |
| Shen, B | 1 |
| Li, X | 1 |
| Wang, F | 1 |
| Yao, X | 1 |
| Yang, D | 1 |
| Paradiso, AM | 1 |
| Coakley, RD | 1 |
| Boucher, RC | 2 |
| Reisin, IL | 1 |
| Prat, AG | 1 |
| Abraham, EH | 1 |
| Amara, JF | 1 |
| Gregory, RJ | 1 |
| Ausiello, DA | 1 |
| Cantiello, HF | 1 |
| McDonough, S | 2 |
| Davidson, N | 2 |
| Lester, HA | 2 |
| McCarty, NA | 2 |
| Faller, DP | 1 |
| Egan, DA | 1 |
| Ryan, MP | 1 |
| Cohen, BN | 1 |
| Riordan, JR | 1 |
| Rückes, C | 1 |
| Blank, U | 1 |
| Möller, K | 1 |
| Rieboldt, J | 1 |
| Lindemann, H | 2 |
| Münker, G | 2 |
| Clauss, W | 2 |
| Weber, WM | 2 |
| Kelley, TJ | 1 |
| Cotton, CU | 1 |
| Drumm, ML | 1 |
| Mailleau, C | 1 |
| Capeau, J | 1 |
| Brahimi-Horn, MC | 1 |
| Loffing, J | 1 |
| Moyer, BD | 1 |
| McCoy, D | 1 |
| Stanton, BA | 1 |
| Pedersen, PS | 1 |
| Frederiksen, O | 1 |
| Holstein-Rathlou, NH | 1 |
| Larsen, PL | 1 |
| Qvortrup, K | 1 |
| Rückes-Nilges, C | 1 |
| Weber, U | 1 |
| Gabriel, SE | 1 |
| Makhlina, M | 1 |
| Martsen, E | 1 |
| Thomas, EJ | 1 |
| Lethem, MI | 1 |
| Walsh, DE | 1 |
| Harvey, BJ | 1 |
| Urbach, V | 1 |
| Bijman, J | 1 |
| Englert, HC | 1 |
| Lang, HJ | 1 |
| Greger, R | 1 |
| Frömter, E | 1 |
17 other studies available for fenamic acid and Cystic Fibrosis
| Article | Year |
|---|---|
Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle.
Topics: Asthma; Bronchi; Calcium; Calcium Channel Blockers; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosi | 2009 |
Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-Agonists; Adult; Bronc | 2011 |
A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 2012 |
Polarized distribution of HCO3- transport in human normal and cystic fibrosis nasal epithelia.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adult; Amiloride; Barium; Bicarbonates; Biological | 2003 |
The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Chloride Channels | 1994 |
Novel pore-lining residues in CFTR that govern permeation and open-channel block.
Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Cystic Fibrosis; Cystic Fibrosis Transmembra | 1994 |
Evidence for location of the CFTR in human placental apical membrane vesicles.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Anions; Bumetanide; Cell M | 1995 |
Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates.
Topics: Animals; Cell Membrane; Chloride Channels; Chlorides; Cyclic AMP; Cystic Fibrosis; Electrophysiology | 1993 |
Amiloride-sensitive Na+ channels in human nasal epithelium are different from classical epithelial Na+ channels.
Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Anti-Infla | 1997 |
In vivo activation of CFTR-dependent chloride transport in murine airway epithelium by CNP.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Anti-Inflammatory Agents, Non- | 1997 |
Interrelationship between the Na+/glucose cotransporter and CFTR in Caco-2 cells: relevance to cystic fibrosis.
Topics: Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Cell Differentiation; Chlorides; Colfo | 1998 |
Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Amiloride; Cell Membrane; Chloride | 1998 |
Ion transport in epithelial spheroids derived from human airway cells.
Topics: Absorption; Adenosine Triphosphate; Amiloride; Biological Transport; Chlorides; Cyclic AMP; Cystic F | 1999 |
Minor role of Cl- secretion in non-cystic fibrosis and cystic fibrosis human nasal epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Amiloride; Calcium Channel | 1999 |
Permeabilization via the P2X7 purinoreceptor reveals the presence of a Ca2+-activated Cl- conductance in the apical membrane of murine tracheal epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bromine; Calcium; Calcium Channel Blocker | 2000 |
CFTR regulation of intracellular calcium in normal and cystic fibrosis human airway epithelia.
Topics: Adenosine Triphosphate; Calcium; Cell Line; Cells, Cultured; Colforsin; Cystic Fibrosis; Cystic Fibr | 2000 |
Characterization of human sweat duct chloride conductance by chloride channel blockers.
Topics: Chlorides; Cystic Fibrosis; Electric Conductivity; Humans; Ion Channels; ortho-Aminobenzoates; Sweat | 1987 |