Page last updated: 2024-10-31

fenamic acid and Cystic Fibrosis

fenamic acid has been researched along with Cystic Fibrosis in 17 studies

fenamic acid: has chloride and potassium channel-blocking activity; RN given refers to parent cpd
fenamic acid : An aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs.

Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Research Excerpts

ExcerptRelevanceReference
"Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, which mediates transepithelial Cl- transport in a variety of epithelia, including airway, intestine, pancreas, and sweat duct."1.30Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells. ( Loffing, J; McCoy, D; Moyer, BD; Stanton, BA, 1998)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's10 (58.82)18.2507
2000's4 (23.53)29.6817
2010's2 (11.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Michoud, MC1
Robert, R1
Hassan, M1
Moynihan, B1
Haston, C1
Govindaraju, V1
Ferraro, P1
Hanrahan, JW1
Martin, JG1
Finkbeiner, WE1
Zlock, LT1
Morikawa, M1
Lao, AY1
Dasari, V1
Widdicombe, JH1
Shen, B1
Li, X1
Wang, F1
Yao, X1
Yang, D1
Paradiso, AM1
Coakley, RD1
Boucher, RC2
Reisin, IL1
Prat, AG1
Abraham, EH1
Amara, JF1
Gregory, RJ1
Ausiello, DA1
Cantiello, HF1
McDonough, S2
Davidson, N2
Lester, HA2
McCarty, NA2
Faller, DP1
Egan, DA1
Ryan, MP1
Cohen, BN1
Riordan, JR1
Rückes, C1
Blank, U1
Möller, K1
Rieboldt, J1
Lindemann, H2
Münker, G2
Clauss, W2
Weber, WM2
Kelley, TJ1
Cotton, CU1
Drumm, ML1
Mailleau, C1
Capeau, J1
Brahimi-Horn, MC1
Loffing, J1
Moyer, BD1
McCoy, D1
Stanton, BA1
Pedersen, PS1
Frederiksen, O1
Holstein-Rathlou, NH1
Larsen, PL1
Qvortrup, K1
Rückes-Nilges, C1
Weber, U1
Gabriel, SE1
Makhlina, M1
Martsen, E1
Thomas, EJ1
Lethem, MI1
Walsh, DE1
Harvey, BJ1
Urbach, V1
Bijman, J1
Englert, HC1
Lang, HJ1
Greger, R1
Frömter, E1

Other Studies

17 other studies available for fenamic acid and Cystic Fibrosis

ArticleYear
Role of the cystic fibrosis transmembrane conductance channel in human airway smooth muscle.
    American journal of respiratory cell and molecular biology, 2009, Volume: 40, Issue:2

    Topics: Asthma; Bronchi; Calcium; Calcium Channel Blockers; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosi

2009
Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:4

    Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-Agonists; Adult; Bronc

2011
A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo

2012
Polarized distribution of HCO3- transport in human normal and cystic fibrosis nasal epithelia.
    The Journal of physiology, 2003, Apr-01, Volume: 548, Issue:Pt 1

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adult; Amiloride; Barium; Bicarbonates; Biological

2003
The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel.
    The Journal of biological chemistry, 1994, Aug-12, Volume: 269, Issue:32

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Chloride Channels

1994
Novel pore-lining residues in CFTR that govern permeation and open-channel block.
    Neuron, 1994, Volume: 13, Issue:3

    Topics: Amino Acid Sequence; Animals; Calcium Channel Blockers; Cystic Fibrosis; Cystic Fibrosis Transmembra

1994
Evidence for location of the CFTR in human placental apical membrane vesicles.
    The American journal of physiology, 1995, Volume: 269, Issue:1 Pt 1

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Anions; Bumetanide; Cell M

1995
Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates.
    The Journal of general physiology, 1993, Volume: 102, Issue:1

    Topics: Animals; Cell Membrane; Chloride Channels; Chlorides; Cyclic AMP; Cystic Fibrosis; Electrophysiology

1993
Amiloride-sensitive Na+ channels in human nasal epithelium are different from classical epithelial Na+ channels.
    Biochemical and biophysical research communications, 1997, Aug-28, Volume: 237, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Anti-Infla

1997
In vivo activation of CFTR-dependent chloride transport in murine airway epithelium by CNP.
    The American journal of physiology, 1997, Volume: 273, Issue:5

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Anti-Inflammatory Agents, Non-

1997
Interrelationship between the Na+/glucose cotransporter and CFTR in Caco-2 cells: relevance to cystic fibrosis.
    Journal of cellular physiology, 1998, Volume: 176, Issue:3

    Topics: Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Cell Differentiation; Chlorides; Colfo

1998
Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Amiloride; Cell Membrane; Chloride

1998
Ion transport in epithelial spheroids derived from human airway cells.
    The American journal of physiology, 1999, Volume: 276, Issue:1

    Topics: Absorption; Adenosine Triphosphate; Amiloride; Biological Transport; Chlorides; Cyclic AMP; Cystic F

1999
Minor role of Cl- secretion in non-cystic fibrosis and cystic fibrosis human nasal epithelium.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 1999, Volume: 9, Issue:1

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Amiloride; Calcium Channel

1999
Permeabilization via the P2X7 purinoreceptor reveals the presence of a Ca2+-activated Cl- conductance in the apical membrane of murine tracheal epithelial cells.
    The Journal of biological chemistry, 2000, Nov-10, Volume: 275, Issue:45

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bromine; Calcium; Calcium Channel Blocker

2000
CFTR regulation of intracellular calcium in normal and cystic fibrosis human airway epithelia.
    The Journal of membrane biology, 2000, Oct-01, Volume: 177, Issue:3

    Topics: Adenosine Triphosphate; Calcium; Cell Line; Cells, Cultured; Colforsin; Cystic Fibrosis; Cystic Fibr

2000
Characterization of human sweat duct chloride conductance by chloride channel blockers.
    Pflugers Archiv : European journal of physiology, 1987, Volume: 408, Issue:5

    Topics: Chlorides; Cystic Fibrosis; Electric Conductivity; Humans; Ion Channels; ortho-Aminobenzoates; Sweat

1987