felypressin and Uterine-Cervical-Neoplasms

To test the hypothesis that prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline when performing large loop excision of the transformation zone of the cervix.. Randomised trial.. Colposcopy clinic in a large district general hospital.. Two hundred consecutive women undergoing large loop excision of the transformation zone of the cervix.. Two different local anaesthetic combinations (prilocaine with felypressin and lignocaine with adrenaline) were compared in women undergoing large loop excision of the transformation zone. Prospective collection of clinical and treatment data was undertaken with scoring using an ordinal scale of pain experienced by the women during the procedure. Peri-operative blood loss and any side effects were also recorded.. Side effects associated with the local anaesthetic agents.. Lignocaine with adrenaline resulted in less blood loss (P = 0.006) but was more likely to cause side effects, such as feeling faint (P = 0.017) and shaking (P < 0.001).. Prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline and is therefore the preferred local anaesthetic combination for large loop excision of the transformation zone.

Topics: Adult; Anesthetics, Combined; Anesthetics, Local; Colposcopy; Epinephrine; Felypressin; Female; Humans; Middle Aged; Prilocaine; Prospective Studies; Uterine Cervical Neoplasms; Vasoconstrictor Agents

Fifty women undergoing laser vaporization of the cervix for cervical intraepithelial neoplasia were randomly allocated to one of two groups. In one group the patients received no anaesthesia, in the other the ectocervix was infiltrated with 2 ml of Citanest with Octapressin (prilocaine 3% with 0.03 i.u./ml. of felypressin) immediately before the procedure. The pain experienced by each group was assessed immediately after treatment by visual analogue and verbal rating scales. The pain experienced by those women receiving local anaesthesia was significantly reduced as assessed by the visual analogue scale (P = 0.011) and this reduction was not quite significant by the verbal rating scale (P = 0.06). The Citanest group had less troublesome bleeding but the difference in bleeding between the two groups was not significant.

Topics: Adult; Anesthesia, Local; Cervix Uteri; Clinical Trials as Topic; Felypressin; Female; Humans; Laser Therapy; Lypressin; Palliative Care; Pregnancy; Prilocaine; Random Allocation; Uterine Cervical Neoplasms

Topics: Anesthetics, Local; Colposcopy; Conization; Felypressin; Female; Humans; Pain Measurement; Pain, Postoperative; Prilocaine; Prospective Studies; Treatment Outcome; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms