felodipine has been researched along with Myocardial Ischemia in 16 studies
Felodipine: A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
felodipine : The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia." | 9.07 | Comparison between felodipine and isosorbide mononitrate as adjunct to beta blockade in patients > 65 years of age with angina pectoris. ( de Vries, RJ; Dunselman, PH; Lie, KI; van den Heuvel, AF; van Veldhuisen, DJ; Wielenga, RP, 1994) |
| "To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0." | 6.67 | [Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993) |
| " To assess the efficacy and safety of the calcium channel blocker, felodipine, and isosorbide mononitrate (ISMN), as adjunct to optimal beta-blocker therapy in elderly patients, a placebo-controlled, double-blind study was conducted in 46 patients, aged between 65 and 80 years, with documented stress-induced angina pectoris and myocardial ischemia." | 5.07 | Comparison between felodipine and isosorbide mononitrate as adjunct to beta blockade in patients > 65 years of age with angina pectoris. ( de Vries, RJ; Dunselman, PH; Lie, KI; van den Heuvel, AF; van Veldhuisen, DJ; Wielenga, RP, 1994) |
| "In 102 patients with high risk (52 patients with history of myocardial infarction, 50 patients with history of cerebral stroke within previous 6-48 months) arterial hypertension (AH) we studied clinical efficacy on angiotensin converting enzyme inhibitor (ACEI) lisinopril, calcium antagonist felodipine, and nonselective - -blocker carvedilol in dependence on salt sensitivity of AH." | 3.76 | [Comparative eficacy of antihypertensive therapy in patients with arterial hypertension and various sensitivity to salt]. ( Babkin, AP; Gladkikh, VV; Gulaia, GI; Pershukov, IV, 2010) |
| "Electron paramagnetic resonance (EPR) spectroscopy was used to investigate the gamma-radiation damage in the crystalline powder form of nine calcium channel blockers from the 1,4-dihydropyridine derivatives, which are in clinical use for treatment of arteria hypertension and ischemic heart disease." | 3.74 | The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state. ( Mielcarek, J; Naskrent, M, 2007) |
| "The calcium antagonist felodipine, the lipid-peroxidation inhibitor H290/51, and the angiotensin II type 1 (AT1)-receptor antagonist candesartan all exert beneficial effects on myocardial ischemia/reperfusion injury." | 3.70 | Combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist provides additive myocardial infarct size-limiting effect in pigs. ( Rydén, L; Shimizu, M; Sjöquist, PO; Wang, QD, 1999) |
| " The purpose of this study was to assess the effects of felodipine as a potentially protective agent against myocardial ischemia and reperfusion injury, independent of any negative inotropic actions, when given after the onset of low-flow ischemia." | 3.69 | Beneficial effects of felodipine on myocardial and coronary function during low-flow ischemia and reperfusion. ( Apstein, CS; Bernstein, EA; Eberli, FR; Horowitz, GL; Silverman, AM, 1996) |
| "To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0." | 2.67 | [Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. ( Ickrath, O; Karsch, KR; Mauser, M; Voelker, W, 1993) |
| "Treatment with felodipine at 10(-10) and 10(-9) M had no effect on the hearts when perfused under aerobic conditions, whilst the higher dose reduced developed pressure from 57." | 1.29 | Effects of felodipine on the ischemic heart: insight into the mechanism of cytoprotection. ( Benigno, M; Bernocchi, P; Cargnoni, A; Ceconi, C; Ferrari, R; Gaia, G; Pasini, E; Pedersini, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (81.25) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Musikhina, NA | 1 |
| Iuferova, OV | 1 |
| Gapon, LI | 1 |
| Makhneva, EA | 1 |
| Belikova, EA | 1 |
| Petelina, TI | 1 |
| Todosiĭchuk, VV | 1 |
| Babkin, AP | 1 |
| Gladkikh, VV | 1 |
| Pershukov, IV | 1 |
| Gulaia, GI | 1 |
| Naskrent, M | 1 |
| Mielcarek, J | 1 |
| Haga, Y | 2 |
| Uriuda, Y | 2 |
| Björkman, JA | 1 |
| Hatori, N | 2 |
| Johansson, L | 1 |
| Nordlander, R | 3 |
| Sjöquist, PO | 5 |
| Rydén, L | 5 |
| Trenkwalder, P | 1 |
| Dobrindt, R | 1 |
| Aulehner, R | 1 |
| Lydtin, H | 1 |
| de Vries, RJ | 1 |
| Dunselman, PH | 1 |
| van Veldhuisen, DJ | 1 |
| van den Heuvel, AF | 1 |
| Wielenga, RP | 1 |
| Lie, KI | 1 |
| Chimienti, M | 1 |
| Negroni, MS | 1 |
| Pusineri, E | 1 |
| Regazzi, MB | 1 |
| Inglese, L | 1 |
| Klersy, C | 1 |
| De Ambroggi, L | 1 |
| Nordlander, M | 1 |
| Mauser, M | 1 |
| Voelker, W | 1 |
| Ickrath, O | 1 |
| Karsch, KR | 1 |
| Bernstein, EA | 1 |
| Eberli, FR | 1 |
| Silverman, AM | 1 |
| Horowitz, GL | 1 |
| Apstein, CS | 1 |
| Wang, QD | 3 |
| Li, XS | 1 |
| Ferrari, R | 1 |
| Cargnoni, A | 1 |
| Bernocchi, P | 1 |
| Gaia, G | 1 |
| Benigno, M | 1 |
| Pasini, E | 1 |
| Pedersini, P | 1 |
| Ceconi, C | 1 |
| Russo, R | 1 |
| Rao, MA | 1 |
| Romano, M | 1 |
| Scotto di Santolo, M | 1 |
| Cardei, S | 1 |
| Giunta, A | 1 |
| Cuocolo, A | 1 |
| Volpe, M | 1 |
| Koenig, W | 1 |
| Höher, M | 1 |
| Shimizu, M | 2 |
5 trials available for felodipine and Myocardial Ischemia
| Article | Year |
|---|---|
[Structural-functional properties of the vascular wall in hypertensive patients with coronary heart disease: effects of felodipin and perindopril].
Topics: Antihypertensive Agents; Arteries; Endothelium, Vascular; Felodipine; Humans; Hypertension; Middle A | 2009 |
Antihypertensive treatment with felodipine but not with a diuretic reduces episodes of myocardial ischaemia in elderly patients with hypertension.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Drug Therapy, Combination; Felodipine; Female; Hemodyn | 1994 |
Comparison between felodipine and isosorbide mononitrate as adjunct to beta blockade in patients > 65 years of age with angina pectoris.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Cross-Over Studies; Delayed-Action Preparations; | 1994 |
[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease].
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Disease; Electrocardiography; Exercise Test; Felodip | 1993 |
Felodipine and amlodipine in stable angina pectoris: results of a randomized double-blind crossover trial.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angina Pectoris; Blood Pressure; Calcium Channel Blocker | 1997 |
11 other studies available for felodipine and Myocardial Ischemia
| Article | Year |
|---|---|
[Comparative eficacy of antihypertensive therapy in patients with arterial hypertension and various sensitivity to salt].
Topics: Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Carbazoles; Carvedil | 2010 |
The effect of ionizing radiation of 1,4-dihydropyridine derivatives in the solid state.
Topics: Calcium Channel Blockers; Dihydropyridines; Electron Spin Resonance Spectroscopy; Felodipine; Gamma | 2007 |
Ischemic and nonischemic tissue concentrations of felodipine after coronary venous retroinfusion during myocardial ischemia and reperfusion: an experimental study in pigs.
Topics: Animals; Felodipine; Female; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Swine | 1994 |
Once daily felodipine in preventing ergonovine-induced myocardial ischaemia in Prinzmetal's variant angina.
Topics: Aged; Angina Pectoris, Variant; Coronary Angiography; Delayed-Action Preparations; Drug Administrati | 1994 |
Coronary venous retroinfusion of felodipine reducing infarct size without affecting regional myocardial blood flow.
Topics: Animals; Coronary Circulation; Coronary Vessels; Felodipine; Female; Hemodynamics; Infusions, Intrav | 1993 |
Beneficial effects of felodipine on myocardial and coronary function during low-flow ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Calcium Channel Blockers; Coronary Circulation; Dose-Response Relat | 1996 |
Coronary venous drug infusion in the ischaemic-reperfused isolated rat heart.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Disease Models, Animal; Felodipine; Heart R | 1996 |
Effects of felodipine on the ischemic heart: insight into the mechanism of cytoprotection.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Dose-Respo | 1996 |
[Prospects of pharmacologic treatment of post-ischemic heart failure].
Topics: Calcium Channel Blockers; Felodipine; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial I | 1995 |
Effects of the angiotensin AT1 receptor blocker candesartan on myocardial ischemic/reperfusion injury.
Topics: Angiotensin Receptor Antagonists; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Calcium | 1999 |
Combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist provides additive myocardial infarct size-limiting effect in pigs.
Topics: Anesthesia; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Antioxidants; Benzim | 1999 |